Search Results - "Haider, Shozeb M"

A structural analysis of G-quadruplex/ligand interactions by Haider, Shozeb M., Neidle, Stephen, Parkinson, Gary N.

“…This focused review article discusses in detail, all available high-resolution small molecule ligand/G-quadruplex structural data derived from crystallographic…”
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A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes by Haider, Shozeb M, Neidle, Stephen

“…The extreme 3'-ends of human telomeres consist of 150-250 nucleotides of single-stranded DNA sequence together with associated proteins. Small-molecule ligands…”
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Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes by Collie, Gavin, Reszka, Anthony P, Haider, Shozeb M, Gabelica, Valérie, Parkinson, Gary N, Neidle, Stephen

“…Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several…”
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Molecular Dynamics Studies of the STAT3 Homodimer:DNA Complex: Relationships between STAT3 Mutations and Protein–DNA Recognition by Husby, Jarmila, Todd, Alan K., Haider, Shozeb M., Zinzalla, Giovanna, Thurston, David E., Neidle, Stephen

“…Signal Transducers and Activators of Transcription (STAT) proteins are a group of latent cytoplasmic transcription factors involved in cytokine signaling…”
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Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe by Zhai, Qianqian, Gao, Chao, Ding, Jieqin, Zhang, Yashu, Islam, Barira, Lan, Wenxian, Hou, Haitao, Deng, Hua, Li, Jun, Hu, Zhe, Mohamed, Hany I, Xu, Shengzhen, Cao, Chunyang, Haider, Shozeb M, Wei, Dengguo

“…Abstract Nucleic acid mimics of fluorescent proteins can be valuable tools to locate and image functional biomolecules in cells. Stacking between the internal…”
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crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex by Collie, Gavin W, Haider, Shozeb M, Neidle, Stephen, Parkinson, Gary N

“…DNA telomeric repeats in mammalian cells are transcribed to guanine-rich RNA sequences, which adopt parallel-stranded G-quadruplexes with a propeller-like…”
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Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G‑Quadruplex-Binding Small Molecule by Marchetti, Chiara, Zyner, Katherine G, Ohnmacht, Stephan A, Robson, Mathew, Haider, Shozeb M, Morton, Jennifer P, Marsico, Giovanni, Vo, Tam, Laughlin-Toth, Sarah, Ahmed, Ahmed A, Di Vita, Gloria, Pazitna, Ingrida, Gunaratnam, Mekala, Besser, Rachael J, Andrade, Ana C. G, Diocou, Seckou, Pike, Jeremy A, Tannahill, David, Pedley, R. Barbara, Evans, T. R. Jeffry, Wilson, W. David, Balasubramanian, Shankar, Neidle, Stephen

“…Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signaling pathways. A novel approach to the treatment of PDAC is…”
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Rational Design of Acridine-Based Ligands with Selectivity for Human Telomeric Quadruplexes by Sparapani, Silvia, Haider, Shozeb M, Doria, Filippo, Gunaratnam, Mekala, Neidle, Stephen

“…Structure-based modeling methods have been used to design a series of disubstituted triazole-linked acridine compounds with selectivity for human telomeric…”
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Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding by Harrison, R. John, Reszka, Anthony P., Haider, Shozeb M., Romagnoli, Barbara, Morrell, James, Read, Martin A., Gowan, Sharon M., Incles, Christopher M., Kelland, Lloyd R., Neidle, Stephen

“…[Display omitted] The synthesis and evaluation of a group of 2,6-, 2,7- and 3,6-bis-aminoalkylamido acridones are reported, which show a similar level of…”
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A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer by Ohnmacht, Stephan A, Marchetti, Chiara, Gunaratnam, Mekala, Besser, Rachael J, Haider, Shozeb M, Di Vita, Gloria, Lowe, Helen L, Mellinas-Gomez, Maria, Diocou, Seckou, Robson, Mathew, Šponer, Jiri, Islam, Barira, Barbara Pedley, R, Hartley, John A, Neidle, Stephen

“…We report here that a tetra-substituted naphthalene-diimide derivative (MM41) has significant in vivo anti-tumour activity against the MIA PaCa-2 pancreatic…”
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Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule by Gunaratnam, Mekala, Swank, Stephen, Haider, Shozeb M, Galesa, Katja, Reszka, Anthony P, Beltran, Monica, Cuenca, Francisco, Fletcher, Jonathan A, Neidle, Stephen

“…Most of human gastrointestinal stromal tumors (GIST) are driven by activating mutations in the proto-oncogene KIT, a tyrosine kinase receptor. Clinical…”
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Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant by Welker Leng, Katherine R, Castañeda, Carol Ann, Decroos, Christophe, Islam, Barira, Haider, Shozeb M, Christianson, David W, Fierke, Carol A

“…Histone deacetylase (HDAC) enzymes that catalyze removal of acetyl-lysine post-translational modifications are frequently post-translationally modified. HDAC8…”
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Modular synthesis of functional libraries by accelerated SuFEx click chemistry by Homer, Joshua A, Koelln, Rebecca A, Barrow, Andrew S, Gialelis, Timothy L, Boiarska, Zlata, Steinohrt, Nikita S, Lee, Erinna F, Yang, Wen-Hsuan, Johnson, Robert M, Chung, Taemoon, Habowski, Amber N, Vishwakarma, Dharmendra S, Bhunia, Debmalya, Avanzi, Charlotte, Moorhouse, Adam D, Jackson, Mary, Tuveson, David A, Lyons, Scott K, Lukey, Michael J, Fairlie, W. Douglas, Haider, Shozeb M, Steinmetz, Michel O, Prota, Andrea E, Moses, John E

“…Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl alcohols with SuFEx-compatible functional groups. With its hallmark…”
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Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter by Todd, Alan K, Haider, Shozeb M, Parkinson, Gary N, Neidle, Stephen

“…The 22-nt c-kit87 promoter sequence is unique within the human genome. Its fold and tertiary structure have recently been determined by NMR methods [Phan,A.T.,…”
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Surface area accessibility and the preferred topology of telomeric DNA quadruplex–ligand complexes by Haider, Shozeb M., Autiero, Ida, Neidle, Stephen

“…Solvent-accessible surface area calculations have been performed on two human telomeric quadruplex structures, the parallel crystal structure and an (3 + 1)…”
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Structure of a G-quadruplex–Ligand Complex by Haider, Shozeb M., Parkinson, Gary N., Neidle, Stephen

“…Stabilisation of G-quadruplex structures formed from telomeric DNA, by means of quadruplex-selective ligands, is a means of inhibiting the telomerase enzyme…”
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Molecular Modeling on Inhibitor Complexes and Active-Site Dynamics of Cytochrome P450 C17, a Target for Prostate Cancer Therapy by Haider, Shozeb M., Patel, Jagdish S., Poojari, Chetan S., Neidle, Stephen

“…A molecular model for the P450 enzyme cytochrome P450 C17 (CYP17) is presented based on sequence alignments of multiple template structures and homology…”
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Biaryl polyamides as a new class of DNA quadruplex-binding ligands by Rahman, Khondaker M, Reszka, Anthony P, Gunaratnam, Mekala, Haider, Shozeb M, Howard, Philip W, Fox, Keith R, Neidle, Stephen, Thurston, David E

“…We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form…”
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N-substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce Pro-apoptosis in Human Hormone-independent Prostate Cancer Cell Lines by Brossard, Dominique, Zhang, Ying, Haider, Shozeb M., Sgobba, Miriam, Khalid, Mohamed, Legay, Rémi, Duterque-Coquillaud, Martine, Galera, Philippe, Rault, Sylvain, Dallemagne, Patrick, Moslemi, Safa, El Kihel, Laïla

“…Nine new 17‐(piperazin‐1‐yl)pyridin‐5‐yl)steroids as abiraterone analogues were synthesized. Compounds 5d and 5g showed selective activities against…”
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Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif by Sparapani, Silvia, Bellini, Stefania, Gunaratnam, Mekala, Haider, Shozeb M, Andreani, Aldo, Rambaldi, Mirella, Locatelli, Alessandra, Morigi, Rita, Granaiola, Massimiliano, Varoli, Lucilla, Burnelli, Silvia, Leoni, Alberto, Neidle, Stephen

“…A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas…”
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