Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome in Patients with Cancer: A Multicenter Study

Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome in Patients with Cancer: A Multicenter Study

: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar syndrome (HHS) are life-threatening complications of diabetes mellitus. However, limited data about DKA and HHS is available in patients with cancer. The current study aimed to determine characteristics and outcomes of patients with cancer...

Full description

Saved in:
Bibliographic Details
Published in:Clinical medicine (London, England) p. 100262
Main Authors: Shahid, Rabia K., Haider, Qasem, Yadav, Sunil, Le, Duc, Ahmed, Shahid
Format: Journal Article
Language:English
Published: Elsevier Ltd 08-11-2024
Subjects:
advanced cancer
cancer
cancer treatment
chemotherapy
diabetes complications
diabetes mellitus
diabetic ketoacidosis
hospital mortality
hyperglycemia hyperosmolar syndrome
immunotherapy
cancer treatment
advanced cancer
diabetic ketoacidosis
immunotherapy
cancer
diabetes mellitus
diabetes complications
hyperglycemia hyperosmolar syndrome
chemotherapy
hospital mortality
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar syndrome (HHS) are life-threatening complications of diabetes mellitus. However, limited data about DKA and HHS is available in patients with cancer. The current study aimed to determine characteristics and outcomes of patients with cancer who were admitted with DKA/HHS in a mid-size Canadian city. : Consecutive adult patients with an active cancer who were admitted with DKA or HHS from January 2008 to December 2020 in the city of Saskatoon, Saskatchewan, Canada were retrospectively evaluated. A univariate logistic regression analysis was performed to examine the correlation of various clinical variables with hospital mortality. : During the study period 6,555 patients with diabetes and cancer were admitted in one of the three tertiary care hospitals. Among them 33 (0.5%) eligible patients with DKA or HHS with a median age of 60 years (range 36–94 years) were identified. In 36% of patients, DKA or HHS was the presenting manifestation of newly diagnosed diabetes. Of all patients, 66% developed DKA and 73% had an advanced cancer. Overall, 52% patients received a systemic cancer therapy prior to the admission, and 41% received steroids. Ten (42%) of 24 patients with an advanced cancer died compared to none of the 9 patients with an early-stage cancer (p=0.032). No clinical factors significantly correlated with hospital mortality. : Although DKA or HHS is uncommon in patients with diabetes and cancer, it is the manifestation of undiagnosed diabetes in about one-third of patients with cancer. It has been associated with a high hospital mortality rate in patients with advanced cancer. [Display omitted]
ISSN:1470-2118
DOI:10.1016/j.clinme.2024.100262