Search Results - "Haian Fu"

Human beige adipocytes for drug discovery and cell therapy in metabolic diseases by Singh, Amar M., Zhang, Liang, Avery, John, Yin, Amelia, Du, Yuhong, Wang, Hui, Li, Zibo, Fu, Haian, Yin, Hang, Dalton, Stephen

“…Human beige adipocytes (BAs) have potential utility for the development of therapeutics to treat diabetes and obesity-associated diseases. Although several…”
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Dual gene activation and knockout screen reveals directional dependencies in genetic networks by Boettcher, Michael, Tian, Ruilin, Blau, James A, Markegard, Evan, Wagner, Ryan T, Wu, David, Mo, Xiulei, Biton, Anne, Zaitlen, Noah, Fu, Haian, McCormick, Frank, Kampmann, Martin, McManus, Michael T

“…Combining gene activation and knockout of different genes in the same cell using two different Cas9 enzymes enables the reconstruction of directional…”
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Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening by Du, Yuhong, Li, Xingnan, Niu, Qiankun, Mo, Xiulei, Qui, Min, Ma, Tingxuan, Kuo, Calvin J, Fu, Haian

“…Abstract The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro…”
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Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease by Zhang, Zhentao, Obianyo, Obiamaka, Dall, Elfriede, Du, Yuhong, Fu, Haian, Liu, Xia, Kang, Seong Su, Song, Mingke, Yu, Shan-Ping, Cabrele, Chiara, Schubert, Mario, Li, Xiaoguang, Wang, Jian-Zhi, Brandstetter, Hans, Ye, Keqiang

“…δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and…”
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The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies by Li, Zenggang, Ivanov, Andrei A., Su, Rina, Gonzalez-Pecchi, Valentina, Qi, Qi, Liu, Songlin, Webber, Philip, McMillan, Elizabeth, Rusnak, Lauren, Pham, Cau, Chen, Xiaoqian, Mo, Xiulei, Revennaugh, Brian, Zhou, Wei, Marcus, Adam, Harati, Sahar, Chen, Xiang, Johns, Margaret A., White, Michael A., Moreno, Carlos S., Cooper, Lee A. D., Du, Yuhong, Khuri, Fadlo R., Fu, Haian

“…As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways…”
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Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases by Horton, John R., Engstrom, Amanda, Zoeller, Elizabeth L., Liu, Xu, Shanks, John R., Zhang, Xing, Johns, Margaret A., Vertino, Paula M., Fu, Haian, Cheng, Xiaodong

“…The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases remove methyl groups from tri- and dimethylated lysine 4 of histone H3…”
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A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation by Lo, Yuan-Hung, Kolahi, Kevin S, Du, Yuhong, Chang, Chiung-Ying, Krokhotin, Andrey, Nair, Ajay, Sobba, Walter D, Karlsson, Kasper, Jones, Sunny J, Longacre, Teri A, Mah, Amanda T, Tercan, Bahar, Sockell, Alexandra, Xu, Hang, Seoane, Jose A, Chen, Jin, Shmulevich, Ilya, Weissman, Jonathan S, Curtis, Christina, Califano, Andrea, Fu, Haian, Crabtree, Gerald R, Kuo, Calvin J

“…Mutations in rank among the most common molecular aberrations in human cancer. However, oncogenic consequences of mutation in human cells remain poorly defined…”
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Acetylation regulates ribonucleotide reductase activity and cancer cell growth by Chen, Guo, Luo, Yin, Warncke, Kurt, Sun, Youwei, Yu, David S., Fu, Haian, Behera, Madhusmita, Ramalingam, Suresh S., Doetsch, Paul W., Duong, Duc M., Lammers, Michael, Curran, Walter J., Deng, Xingming

“…Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here,…”
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2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells by Sun, Linlin, Liu, Xiuju, Fu, Haian, Zhou, Wei, Zhong, Diansheng

“…Tumor cells rely on aerobic glycolysis to generate ATP, namely the "Warburg" effect. 2-deoxyglucose (2-DG) is well characterized as a glycolytic inhibitor, but…”
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Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism by Hitosugi, Taro, Fan, Jun, Chung, Tae-Wook, Lythgoe, Katherine, Wang, Xu, Xie, Jianxin, Ge, Qingyuan, Gu, Ting-Lei, Polakiewicz, Roberto D., Roesel, Johannes L., Chen, Georgia Z., Boggon, Titus J., Lonial, Sagar, Fu, Haian, Khuri, Fadlo R., Kang, Sumin, Chen, Jing

“…Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. Myc and HIF-1 are believed to…”
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How Does Arrestin Assemble MAPKs into a Signaling Complex? by Song, Xiufeng, Coffa, Sergio, Fu, Haian, Gurevich, Vsevolod V.

“…Arrestins bind active phosphorylated G protein-coupled receptors, precluding G protein activation and channeling signaling to alternative pathways. Arrestins…”
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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition by Sun, Shi-Yong, Rosenberg, Laura M, Wang, Xuerong, Zhou, Zhongmei, Yue, Ping, Fu, Haian, Khuri, Fadlo R

“…The mammalian target of rapamycin (mTOR) has emerged as an important cancer therapeutic target. Rapamycin and its derivatives that specifically inhibit mTOR…”
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Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways by Zhao, Ruolin, Chen, Meijuan, Jiang, Zequn, Zhao, Fengming, Xi, Beili, Zhang, Xu, Fu, Haian, Zhou, Kunfu

“…Platycodin-D (PD) is an effective triterpene saponin extracted from the root of Platycodon grandiflorum which has been used clinically to treat pulmonary…”
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Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F by Cencic, Regina, Hall, David R., Robert, Francis, Du, Yuhong, Min, Jaeki, Li, Lian, Qui, Min, Lewis, Iestyn, Kurtkaya, Serdar, Dingledine, Ray, Fu, Haian, Kozakov, Dima, Vajda, Sandor, Pelletier, Jerry, Housman, David E.

“…Deregulation of cap-dependent translation is associated with cancer initiation and progression. The rate-limiting step of protein synthesis is the loading of…”
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Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival by Yang, Qian, Li, Wenming, She, Hua, Dou, Juan, Duong, Duc M., Du, Yuhong, Yang, Shao-Hua, Seyfried, Nicholas T., Fu, Haian, Gao, Guodong, Mao, Zixu

“…MicroRNAs (miRNAs) regulate the translational potential of their mRNA targets and control many cellular processes. The key step in canonical miRNA biogenesis…”
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Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma by Lei, Kecheng, Gu, Xiaoxia, Alvarado, Alvaro G, Du, Yuhong, Luo, Shilin, Ahn, Eun Hee, Kang, Seong Su, Ji, Bing, Liu, Xia, Mao, Hui, Fu, Haian, Kornblum, Harley I, Jin, Lingjing, Li, Hua, Ye, Keqiang

“…Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase…”
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Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation by Wang, Xuerong, Yue, Ping, Kim, Young Ae, Fu, Haian, Khuri, Fadlo R, Sun, Shi-Yong

“…It has been shown that mammalian target of rapamycin (mTOR) inhibitors activate Akt while inhibiting mTOR signaling. However, the underlying mechanisms and the…”
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Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice by Druzak, Samuel A., Tardelli, Matteo, Mays, Suzanne G., El Bejjani, Mireille, Mo, Xulie, Maner-Smith, Kristal M., Bowen, Thomas, Cato, Michael L., Tillman, Matthew C., Sugiyama, Akiko, Xie, Yang, Fu, Haian, Cohen, David E., Ortlund, Eric A.

“…Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding protein that transports phosphatidylcholine (PC) between cellular…”
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High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients by Yang, Xuan, Amgad, Mohamed, Cooper, Lee A D, Du, Yuhong, Fu, Haian, Ivanov, Andrey A

“…African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than…”
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Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds by Horton, John R, Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R, Zhang, Xing, Webber, Philip J, Bell, Joshua S K, Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A, Fu, Haian, Jadhav, Ajit, Vertino, Paula M, Yan, Qin, Cheng, Xiaodong

“…The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating…”
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