Search Results - "Hahnel, R."

The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits by Zhang, Gaotian, Roberto, Nicole M., Lee, Daehan, Hahnel, Steffen R., Andersen, Erik C.

“…Phenotypic variation in organism-level traits has been studied in Caenorhabditis elegans wild strains, but the impacts of differences in gene expression and…”
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Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles by Hahnel, Steffen R, Zdraljevic, Stefan, Rodriguez, Briana C, Zhao, Yuehui, McGrath, Patrick T, Andersen, Erik C

“…Benzimidazoles (BZ) are essential components of the limited chemotherapeutic arsenal available to control the global burden of parasitic nematodes. The…”
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Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis by Bah, Germanus S, Schneckener, Sebastian, Hahnel, Steffen R, Bayang, Nicolas H, Fieseler, Helena, Schmuck, Gabriele M, Krebber, Ralph, Sarr, Anouk, Terjung, Carsten, Ngangyung, Henrietta F, Ekale, David D, Mfopit, Youssouf M, Rufener, Lucien, Graham-Brown, John, Tanya, Vincent N, Glenschek-Sieberth, Martin, Kulke, Daniel, Makepeace, Benjamin L

“…Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus , is a neglected tropical disease mostly affecting sub-Saharan Africa and is…”
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Caenorhabditis elegans in anthelmintic research – Old model, new perspectives by Hahnel, Steffen R., Dilks, Clayton M., Heisler, Iring, Andersen, Erik C., Kulke, Daniel

“…For more than four decades, the free-living nematode Caenorhabditis elegans has been extensively used in anthelmintic research. Classic genetic screens and…”
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Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration by Krücken, Jürgen, Holden-Dye, Lindy, Keiser, Jennifer, Prichard, Roger K, Townson, Simon, Makepeace, Benjamin L, Hübner, Marc P, Hahnel, Steffen R, Scandale, Ivan, Harder, Achim, Kulke, Daniel

“…Current mass drug administration (MDA) programs for the treatment of human river blindness (onchocerciasis) caused by the filarial worm Onchocerca volvulus…”
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Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles by Dilks, Clayton M., Hahnel, Steffen R., Sheng, Qicong, Long, Lijiang, McGrath, Patrick T., Andersen, Erik C.

“…Infections by parasitic nematodes inflict a huge burden on the health of humans and livestock throughout the world. Anthelmintic drugs are the first line of…”
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Two novel loci underlie natural differences in Caenorhabditis elegans abamectin responses by Evans, Kathryn S, Wit, Janneke, Stevens, Lewis, Hahnel, Steffen R, Rodriguez, Briana, Park, Grace, Zamanian, Mostafa, Brady, Shannon C, Chao, Ellen, Introcaso, Katherine, Tanny, Robyn E, Andersen, Erik C

“…Parasitic nematodes cause a massive worldwide burden on human health along with a loss of livestock and agriculture productivity. Anthelmintics have been…”
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Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni by Kellershohn, Josina, Thomas, Laura, Hahnel, Steffen R, Grünweller, Arnold, Hartmann, Roland K, Hardt, Martin, Vilcinskas, Andreas, Grevelding, Christoph G, Haeberlein, Simone

“…Natural products have moved into the spotlight as possible sources for new drugs in the treatment of helminth infections including schistosomiasis…”
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Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans by Hahnel, Steffen R., Roberts, William M., Heisler, Iring, Kulke, Daniel, Weeks, Janis C.

“…Currently, only a few chemical drug classes are available to control the global burden of nematode infections in humans and animals. Most of these drugs exert…”
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Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside by Hübner, Marc P., Townson, Simon, Gokool, Suzanne, Tagboto, Senyo, Maclean, Mary J., Verocai, Guilherme G., Wolstenholme, Adrian J., Frohberger, Stefan J., Hoerauf, Achim, Specht, Sabine, Scandale, Ivan, Harder, Achim, Glenschek-Sieberth, Martin, Hahnel, Steffen R., Kulke, Daniel

“…Filariae are vector-borne nematodes responsible for an enormous burden of disease. Human lymphatic filariasis, caused by Wuchereria bancrofti, Brugia malayi,…”
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Reduced breast cancer risk with increasing serum folate in a case–control study of the C677T genotype of the methylenetetrahydrofolate reductase gene by Beilby, J, Ingram, D, Hähnel, R, Rossi, E

“…Breast cancer risk may be associated with folate status or the C677T genotype of the methylenetetrahydrofolate reductase (MTHFR) gene. We compared serum folate…”
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Identification of a new panel of reference genes to study pairing-dependent gene expression in Schistosoma mansoni by Haeberlein, Simone, Angrisano, Alexandra, Quack, Thomas, Lu, Zhigang, Kellershohn, Josina, Blohm, Ariane, Grevelding, Christoph G., Hahnel, Steffen R.

“…[Display omitted] •Reference genes for qRT-PCR analyses should be newly validated for each experimental setup in schistosome research.•Combined analysis with…”
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Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram by Beutler, Mandy, Harnischfeger, Julie, Weber, Michael H.W., Hahnel, Steffen R., Quack, Thomas, Blohm, Ariane, Ueberall, Monique E., Timm, Thomas, Lochnit, Günter, Rennar, Georg A., Gallinger, Tom L., Houhou, Hicham, Rahlfs, Stefan, Falcone, Franco H., Becker, Katja, Schlitzer, Martin, Haeberlein, Simone, Czermak, Peter, Salzig, Denise, Grevelding, Christoph G.

“…Schistosomiasis is an infectious disease caused by blood flukes of the genus Schistosoma and affects approximately 200 million people worldwide. Since…”
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A Novel Electronically Wideband Steering System using Rotman Lens for 5G Applications at 28 GHz by Hassanien, MA, Hahnel, R, Plettemeier, D

“…this paper presents the design, simulation and measurement results for a beam steerable system, which covers the frequency range from 22 GHz to 35 GHz for 5G…”
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Distributed on-chip antennas to increase system bandwidth at 180 GHz by Hahnel, R., Klein, B., Hammerschmidt, C., Plettemeier, D., Testa, P. V., Carta, C., Ellinger, F.

“…This paper presents integrated, distributed on-chip antennas. The aim is to achieve a higher system bandwidth due to the utilization of multiple antennas and…”
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Expression of the PIP/GCDFP-15 gene and survival in breast cancer by H hnel, R., H hnel, E.

“…Expression of the PIP/GCDFP-15 gene was determined by measuring PIP/GCDFP-15-mRNA in breast carcinomas of 91 patients. The patients were followed-up for an…”
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Direct observations of asteroid interior and regolith structure: Science measurement requirements by Herique, A., Agnus, B., Asphaug, E., Barucci, A., Beck, P., Bellerose, J., Biele, J., Bonal, L., Bousquet, P., Bruzzone, L., Buck, C., Carnelli, I., Cheng, A., Ciarletti, V., Delbo, M., Du, J., Du, X., Eyraud, C., Fa, W., Gil Fernandez, J., Gassot, O., Granados-Alfaro, R., Green, S.F., Grieger, B., Grundmann, J.T., Grygorczuk, J., Hahnel, R., Heggy, E., Ho, T-M., Karatekin, O., Kasaba, Y., Kobayashi, T., Kofman, W., Krause, C., Kumamoto, A., Küppers, M., Laabs, M., Lange, C., Lasue, J., Levasseur-Regourd, A.C., Mallet, A., Michel, P., Mottola, S., Murdoch, N., Mütze, M., Oberst, J., Orosei, R., Plettemeier, D., Rochat, S., RodriguezSuquet, R., Rogez, Y., Schaffer, P., Snodgrass, C., Souyris, J-C., Tokarz, M., Ulamec, S., Wahlund, J-E., Zine, S.

“…Our knowledge of the internal structure of asteroids is, so far, indirect – relying entirely on inferences from remote sensing observations of the surface, and…”
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Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas by Hähnel, R, Harvey, J, Kay, P

“…The methylation status of Myf-3 was studied in 34 human primary breast carcinomas and 9 normal breast tissues. One third of the carcinomas contained…”
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Investigation of sex-hormone binding globulin interference in direct radioimmunoassays for testosterone and estradiol by Masters, A M, Hähnel, R

“…The aim of this study was to find reasons for the interference of sex-hormone binding globulin (SHBG) in direct radioimmunoassays (RIAs) for testosterone and…”
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The effect of hormone replacement therapy on prognostic indices in women with breast cancer by Jones, C, Ingram, D, Mattes, E, Hahnel, R

“…To examine the effect of hormone replacement therapy (HRT) on breast cancer biology. Four hundred and sixty Western Australian women with breast cancer who…”
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