Search Results - "Hahne, Michael"

Mixed signals from the cell's antennae: primary cilia in cancer by Eguether, Thibaut, Hahne, Michael

“…Primary cilia (PC) are antenna‐like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways…”
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The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis by Asif, Paris Jabeen, Longobardi, Ciro, Hahne, Michael, Medema, Jan Paul

“…Cancer-associated fibroblasts (CAFs) play a key role in cancer progression by contributing to extracellular matrix (ECM) deposition and remodeling, extensive…”
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IL-10 Producing B Cells Ability to Induce Regulatory T Cells Is Maintained in Rheumatoid Arthritis by Mielle, Julie, Audo, Rachel, Hahne, Michael, Macia, Laurence, Combe, Bernard, Morel, Jacques, Daien, Claire

“…Despite growing evidence highlighting the relevance of increasing IL-10-producing B cells (B10 cells) in autoimmune diseases, their functions in patients are…”
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Anti-inflammatory role of APRIL by modulating regulatory B cells in antigen-induced arthritis by Carvalho-Santos, Adriana, Ballard Kuhnert, Lia Rafaella, Hahne, Michael, Vasconcellos, Rita, Carvalho-Pinto, Carla Eponina, Villa-Verde, Déa Maria Serra

“…APRIL (A Proliferation-Inducing Ligand), a member of the TNF superfamily, was initially described for its ability to promote proliferation of tumor cells in…”
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A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells by Hua, Charlotte, Audo, Rachel, Yeremenko, Nataliya, Baeten, Dominique, Hahne, Michael, Combe, Bernard, Morel, Jacques, Daïen, Claire

“…Abstract B cells may have a negative regulatory role, mainly mediated by interleukin 10 (IL-10). We recently showed that regulatory B-cell functions are…”
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APRIL Induces a Novel Subset of IgA + Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1 by Fehres, Cynthia M, van Uden, Nathalie O, Yeremenko, Nataliya G, Fernandez, Leticia, Franco Salinas, Gabriela, van Duivenvoorde, Leonie M, Huard, Bertrand, Morel, Jacques, Spits, Hergen, Hahne, Michael, Baeten, Dominique L P

“…Regulatory B cells (Bregs) are immunosuppressive cells that modulate immune responses through multiple mechanisms. The signals required for the differentiation…”
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Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon by Rocha, Cecilia, Papon, Laura, Cacheux, Wulfran, Marques Sousa, Patricia, Lascano, Valeria, Tort, Olivia, Giordano, Tiziana, Vacher, Sophie, Lemmers, Benedicte, Mariani, Pascale, Meseure, Didier, Medema, Jan Paul, Bièche, Ivan, Hahne, Michael, Janke, Carsten

“…TTLL3 and TTLL8 are tubulin glycine ligases catalyzing posttranslational glycylation of microtubules. We show here for the first time that these enzymes are…”
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Author Correction: The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium by Maurizy, Chloé, Abeza, Claire, Lemmers, Bénédicte, Gabola, Monica, Longobardi, Ciro, Pinet, Valérie, Ferrand, Marina, Paul, Conception, Bremond, Julie, Langa, Francina, Gerbe, François, Jay, Philippe, Verheggen, Céline, Tinari, Nicola, Helmlinger, Dominique, Lattanzio, Rossano, Bertrand, Edouard, Hahne, Michael, Pradet-Balade, Bérengère

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A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis by Baert, Laurie, Benkhoucha, Mahdia, Popa, Natalia, Ahmed, Mashal C., Manfroi, Benoit, Boutonnat, Jean, Sturm, Nathalie, Raguenez, Gilda, Tessier, Marine, Casez, Olivier, Marignier, Romain, Ahmadi, Mitra, Broisat, Alexis, Ghezzi, Catherine, Rivat, Cyril, Sonrier, Corinne, Hahne, Michael, Baeten, Dominique, Vives, Romain R., Lortat‐Jacob, Hugues, Marche, Patrice N., Schneider, Pascal, Lassmann, Hans P., Boucraut, Jose, Lalive, Patrice H., Huard, Bertrand

“…Objective The two related tumor necrosis factor members a proliferation‐inducing ligand (APRIL) and B‐cell activation factor (BAFF) are currently targeted in…”
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The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium by Maurizy, Chloé, Abeza, Claire, Lemmers, Bénédicte, Gabola, Monica, Longobardi, Ciro, Pinet, Valérie, Ferrand, Marina, Paul, Conception, Bremond, Julie, Langa, Francina, Gerbe, François, Jay, Philippe, Verheggen, Céline, Tinari, Nicola, Helmlinger, Dominique, Lattanzio, Rossano, Bertrand, Edouard, Hahne, Michael, Pradet-Balade, Bérengère

“…The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown…”
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Targeting the Fas/FasL system in Rheumatoid Arthritis therapy: Promising or risky? by Calmon-Hamaty, Flavia, Audo, Rachel, Combe, Bernard, Morel, Jacques, Hahne, Michael

“…•Apoptotic pathways, particularly the ones involving Fas/FasL, are defective in RA.•The Fas-FasL system may instead have a proinflammatory effect in RA.•sFasL…”
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mTOR intersects antibody-inducing signals from TACI in marginal zone B cells by Sintes, Jordi, Gentile, Maurizio, Zhang, Shuling, Garcia-Carmona, Yolanda, Magri, Giuliana, Cassis, Linda, Segura-Garzón, Daniel, Ciociola, Alessandra, Grasset, Emilie K., Bascones, Sabrina, Comerma, Laura, Pybus, Marc, Lligé, David, Puga, Irene, Gutzeit, Cindy, He, Bing, DuBois, Wendy, Crespo, Marta, Pascual, Julio, Mensa, Anna, Aróstegui, Juan Ignacio, Juan, Manel, Yagüe, Jordi, Serrano, Sergi, Lloreta, Josep, Meffre, Eric, Hahne, Michael, Cunningham-Rundles, Charlotte, Mock, Beverly A., Cerutti, Andrea

“…Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic…”
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PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity by Audo, Rachel, Deckert, Valérie, Daien, Claire I, Che, Hélène, Elhmioui, Jamila, Lemaire, Stéphanie, Pais de Barros, Jean-Paul, Desrumaux, Catherine, Combe, Bernard, Hahne, Michael, Lagrost, Laurent, Morel, Jacques

“…Rheumatoid arthritis (RA) is a chronic inflammatory rheumatic disease with modification of lipids profile and an increased risk of cardiovascular events…”
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SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases by Bendris, Nawal, Williams, Karla C, Reis, Carlos R, Welf, Erik S, Chen, Ping-Hung, Lemmers, Bénédicte, Hahne, Michael, Leong, H S, Schmid, Sandra L

“…Despite current advances in cancer research, metastasis remains the leading factor in cancer-related deaths. Here, we identify sorting nexin 9 (SNX9) as a new…”
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Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion by Human Regulatory B Cells by Audo, Rachel, Hua, Charlotte, Hahne, Michael, Combe, Bernard, Morel, Jacques, Daien, Claire I

“…B cells can have a regulatory role, mainly mediated by interleukin 10 (IL-10). IL-10 producing B cells (B10 cells) cells remain to be better characterized…”
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The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages by Chebli, Karim, Papon, Laura, Paul, Conception, Garcel, Aude, Campos, Noëlie, Scherrer, Didier, J. Ehrlich, Hartmut, Hahne, Michael, Tazi, Jamal

“…The progression of human immunodeficiency virus (HIV) is associated with mucosal damage in the gastrointestinal (GI) tract. This damage enables bacterial…”
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Effects of Different Housing Systems during Suckling and Rearing Period on Skin and Tail Lesions, Tail Losses and Performance of Growing and Finishing Pigs by Lange, Anita, Hahne, Michael, Lambertz, Christian, Gauly, Matthias, Wendt, Michael, Janssen, Heiko, Traulsen, Imke

“…Feasible alternatives to stressful weaning and tail-docking are needed to inhibit tail biting. Therefore, we investigated the effects of housing systems for…”
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Effects of Different Farrowing and Rearing Systems on Post-Weaning Stress in Piglets by Lange, Anita, Gentz, Maria, Hahne, Michael, Lambertz, Christian, Gauly, Matthias, Burfeind, Onno, Traulsen, Imke

“…This study aimed to investigate how farrowing and rearing systems affect skin lesions, serum cortisol, and aggressive behavior as indicators for weaning stress…”
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Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Rheumatoid Arthritis Synovial Fibroblast Proliferation through Mitogen-activated Protein Kinases and Phosphatidylinositol 3-Kinase/Akt by Morel, Jacques, Audo, Rachel, Hahne, Michael, Combe, Bernard

“…A hallmark of rheumatoid arthritis (RA) is the pseudo-tumoral expansion of fibroblast-like synoviocytes (FLSs), and the RA FLS has therefore been proposed as a…”
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Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance by Damiani, Verena, Lamolinara, Alessia, Cicalini, Ilaria, Cufaro, Maria Concetta, Del Pizzo, Francesco, Di Marco, Federica, Del Boccio, Piero, Dufrusine, Beatrice, Hahne, Michael, Lattanzio, Rossano, Pieragostino, Damiana, Iezzi, Manuela, Federici, Massimo, Turco, Maria Caterina, Maiorana, Arianna, Dionisi-Vici, Carlo, De Laurenzi, Vincenzo

“…Insulin, secreted from pancreatic islets of Langerhans, is of critical importance in regulating glucose homeostasis. Defective insulin secretion and/or the…”
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