Search Results - "Hahn, Young"

Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection by Gorski, Stacey Ann, Hahn, Young S, Braciale, Thomas J

“…Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine) immune response, however, the production of type…”
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Myeloid-derived suppressor cells: the dark knight or the joker in viral infections? by Goh, Celeste, Narayanan, Sowmya, Hahn, Young S.

“…Summary Myeloid derived suppressor cells (MDSCs) are immature cells of myeloid origin, frequently found in tumor microenvironments and in the blood of cancer…”
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Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production by Tosello-Trampont, Annie-Carole, Landes, Susan G., Nguyen, Virginia, Novobrantseva, Tatiana I., Hahn, Young S.

“…Nonalcoholic steatohepatitis (NASH), characterized by lipid deposits within hepatocytes (steatosis), is associated with hepatic injury and inflammation and…”
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The role of macrophage polarization in infectious and inflammatory diseases by Labonte, Adam C, Tosello-Trampont, Annie-Carole, Hahn, Young S

“…Macrophages, found in circulating blood as well as integrated into several tissues and organs throughout the body, represent an important first line of defense…”
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Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis by Nam, Da-Eun, Park, Soo-Jeung, Omole, Samson, Um, Eugene, Hakami, Ramin M, Hahn, Young S

“…Chronic liver diseases are caused by hepatic viral infection, chemicals, and metabolic stress. The protein Grb2-associated binder 1 (Gab1) binds to various…”
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NKp46+ natural killer cells attenuate metabolism‐induced hepatic fibrosis by regulating macrophage activation in mice by Tosello‐Trampont, Annie‐Carole, Krueger, Peter, Narayanan, Sowmya, Landes, Susan G., Leitinger, Norbert, Hahn, Young S.

“…Nonalcoholic steatohepatitis (NASH) affects 3%‐5% of the U.S. population, having severe clinical complications to the development of fibrosis and end‐stage…”
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Immunity to viruses by Braciale, Thomas J., Hahn, Young S.

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Role of neuronal NADPH oxidase 1 in the peri-infarct regions after stroke by Choi, Dong-Hee, Kim, Ji-Hye, Lee, Kyoung-Hee, Kim, Hahn-Young, Kim, Yoon-Seong, Choi, Wahn Soo, Lee, Jongmin

“…The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused by ischemia-reperfusion (I/R) injury remains unknown. We…”
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Site-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivo by Lim, Sung In, Hahn, Young S., Kwon, Inchan

“…Albumin fusion/conjugation (albumination) has been an effective method to prolong in vivo half-life of therapeutic proteins. However, its broader application…”
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Hepatocytes infected with hepatitis C virus change immunological features in the liver microenvironment by Park, Soo-Jeung, Hahn, Young S

“…Hepatitis C virus (HCV) infection is remarkably efficient in establishing viral persistence, leading to the development of liver cirrhosis and hepatocellular…”
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Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms by Kwon, Kyoung Ja, Kim, Hahn Young, Han, Seol-Heui, Shin, Chan Young

“…Alzheimer’s disease (AD) is a progressive, degenerative brain disorder that impairs memory and thinking skills, leading to significant economic and humanistic…”
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Site-specific fatty acid-conjugation to prolong protein half-life in vivo by Lim, Sung In, Mizuta, Yukina, Takasu, Akinori, Hahn, Young S., Kim, Yong Hwan, Kwon, Inchan

“…Therapeutic proteins are indispensable in treating numerous human diseases. However, therapeutic proteins often suffer short serum half-life. In order to…”
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Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration by Tosello-Trampont, Annie, Surette, Fionna A, Ewald, Sarah E, Hahn, Young S

“…NK cells represent an important first line of defense against viral infection and cancer and are also involved in tissue homeostasis. Studies of NK cell…”
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Major roles of kupffer cells and macrophages in NAFLD development by Park, Soo-Jeung, Garcia Diaz, Josefina, Um, Eugene, Hahn, Young S

“…Non-alcoholic fatty liver disease (NAFLD) is an important public health problem with growing numbers of NAFLD patients worldwide. Pathological conditions are…”
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Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1 by Goh, Celeste C, Roggerson, Krystal M, Lee, Hai-Chon, Golden-Mason, Lucy, Rosen, Hugo R, Hahn, Young S

“…The hepatitis C virus (HCV) infects ∼ 200 million people worldwide. The majority of infected individuals develop persistent infection, resulting in chronic…”
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Role of matrix metalloproteinases in delayed cortical responses after stroke by Lo, Eng H, Zhao, Bing-Qiao, Wang, Sophia, Kim, Hahn-Young, Storrie, Hannah, Rosen, Bruce R, Mooney, David J, Wang, Xiaoying

“…Matrix metalloproteinases (MMPs) are zinc-endopeptidases with multifactorial actions in central nervous system (CNS) physiology and pathology. Accumulating…”
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The Pannexin 1/Purinergic Receptor P2X4 Pathway Controls the Secretion of MicroRNA‐Containing Exosomes by HCV‐Infected Hepatocytes by Kim, Ok‐Kyung, Nam, Da‐eun, Hahn, Young S.

“…Background and Aims HCV infection is a major risk factor that can lead to chronic liver disease, including fibrosis, cirrhosis, and HCC. Progression of chronic…”
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Unveiling the Lymphatic System of the Brain by Jeong, Mose, Back, Dong Bin, Kim, Hahn Young

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IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus–infected human macrophages by Magoro, Tshifhiwa, Dandekar, Aditya, Jennelle, Lucas T., Bajaj, Rohan, Lipkowitz, Gabriel, Angelucci, Angelina R., Bessong, Pascal O., Hahn, Young S.

“…Zika virus (ZIKV)3 is an enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as a public health threat because of…”
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Hepatocyte‐derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection by Cobb, Dustin A., Kim, Ok‐Kyung, Golden‐Mason, Lucy, Rosen, Hugo R., Hahn, Young S.

“…Hepatitis C virus (HCV) is a global health concern that can cause severe liver disease, such as cirrhosis and hepatocellular carcinoma. Control of HCV requires…”
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