Search Results - "Hahn, E M"

Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture by Ehlen, L, Arndt, J, Treue, D, Bischoff, P, Loch, F N, Hahn, E M, Kotsch, K, Klauschen, F, Beyer, K, Margonis, G A, Kreis, M E, Kamphues, C

“…Pancreatic cancer remains a fatal disease. Experimental systems are needed for personalized treatment strategies, drug testing and to further understand tumor…”
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Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero by Hahn, Karin M.E., Johnson, Peter H., Gordon, Nancy, Kuerer, Henry, Middleton, Lavinia, Ramirez, Mildred, Yang, Wei, Perkins, George, Hortobagyi, Gabriel N., Theriault, Richard L.

“…BACKGROUND As women in the US delay childbearing, it has been hypothesized that the incidence of breast cancer diagnosed during pregnancy will increase. There…”
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Factors Associated with Advanced Disease Stage at Diagnosis in a Population-based Study of Patients with Newly Diagnosed Breast Cancer by Hahn, Karin M. E., Bondy, Melissa L., Selvan, Mano, Lund, Mary Jo, Liff, Jonathan M., Flagg, Elaine W., Brinton, Louise A., Porter, Peggy, Eley, J. William, Coates, Ralph J.

“…Breast cancer is diagnosed at a younger age and a more advanced stage in African-American women than in White women. The authors investigated the effects of…”
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Anomalous Contraction Scour? Vertical-Contraction Case by Hahn, E. M, Lyn, D. A

“…Clear-water scour due to a short vertical (pressure flow) contraction was investigated in a laboratory channel. Two approach velocities were studied for a…”
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Acquired Resistance to Ah Receptor Agonists in a Population of Atlantic Killifish (Fundulus heteroclitus) Inhabiting a Marine Superfund Site: In Vivo and in Vitro Studies on the Inducibility of Xenobiotic Metabolizing Enzymes by Bello, Susan M., Franks, Diana G., Stegeman, John J., Hahn, Mark E.

“…New Bedford Harbor (NBH), MA, is a federal Superfund site that is heavily contaminated with polychlorinated biphenyls (PCBs) and other halogenated aromatic…”
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Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness by Tarrant, A M, Greytak, S R, Callard, G V, Hahn, M E

“…The estrogen receptor-related receptors (ERRs) are a group of nuclear receptors that were originally identified on the basis of sequence similarity to the…”
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Cytochrome P4501A Induction in Avian Hepatocyte Cultures: A Promising Approach for Predicting the Sensitivity of Avian Species to Toxic Effects of Halogenated Aromatic Hydrocarbons by Kennedy, S.W., Lorenzen, A., Jones, S.P., Hahn, M.E., Stegeman, J.J.

“…Concentration-dependent effects of halogenated aromatic hydrocarbons (HAHs) on cytochrome P4501A (CYP1A) induction in primary hepatocyte cultures prepared from…”
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cDNA Cloning and Characterization of a High Affinity Aryl Hydrocarbon Receptor in a Cetacean, the Beluga, Delphinapterus leucas by Jensen, Brenda A., Hahn, Mark E.

“…Some cetaceans bioaccumulate substantial concentrations of planar halogenated aromatic hydrocarbons (PHAHs) in their tissues, but little is known about the…”
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The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome by Goldstone, J.V., Hamdoun, A., Cole, B.J., Howard-Ashby, M., Nebert, D.W., Scally, M., Dean, M., Epel, D., Hahn, M.E., Stegeman, J.J.

“…Metazoan genomes contain large numbers of genes that participate in responses to environmental stressors. We surveyed the sea urchin Strongylocentrotus…”
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Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARγ by Crawford, K.A., Clark, B.W., Heiger-Bernays, W.J., Karchner, S.I., Hahn, M.E., Nacci, D.E., Schlezinger, J.J.

“…•TBT induced caudal fin deformity in killifish embryos.•Susceptibility was the same in PCB-sensitive and PCB-tolerant killifish.•An RXR-ligand recapitulated…”
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The Role of Polycyclic Aromatic Hydrocarbon Metabolism in Dimethylbenz[a]anthracene-Induced Pre-B Lymphocyte Apoptosis by Mann, K.K., Matulka, R.A., Hahn, M.E., Trombino, A.F., Lawrence, B.P., Kerkvliet, N.I., Sherr, D.H.

“…Previous studies indicated that two prototypic PAH, benzo[a]pyrene (B[a]P) and 7,12-dimethylbenz[a]anthracene (DMBA), suppress the developing immune system by…”
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Serum Alters the Uptake and Relative Potencies of Halogenated Aromatic Hydrocarbons in Cell Culture Bioassays by Hestermann, Eli V., Stegeman, John J., Hahn, Mark E.

“…The effects of many chemicals on cellular processes are governed by their ability to enter the cell, which is in turn a function of the composition of the…”
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Evolutionary conservation of the vertebrate Ah (dioxin) receptor: amplification and sequencing of the PAS domain of a teleost Ah receptor cDNA by Hahn, M E, Karchner, S I

“…The PAS domain of a teleost Ah receptor was amplified using reverse transcription-PCR with degenerate primers containing inosine. The deduced amino acid…”
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Low Inducibility of CYP1A Activity by Polychlorinated Biphenyls (PCBs) in Flounder (Platichthys flesus): Characterization of the Ah Receptor and the Role of CYP1A Inhibition by Besselink, H.T., Denison, M.S., Hahn, M.E., Karchner, S.I., Vethaak, A.D., Koeman, J.H., Brouwer, A.

“…Several studies have reported a low inducibility of hepatic cytochrome P4501A (CYP1A) activity in European flounder (Platichthys flesus) following exposure to…”
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Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup) by Smolowitz, R M, Hahn, M E, Stegeman, J J

“…The regulation of different cytochrome P-450 forms and their functions in different organs and cell types could determine the susceptibility of those cells and…”
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Genetic and developmental influences on infant mouse ultrasonic calling. II. Developmental patterns in the calls of mice 2-12 days of age by Hahn, M E, Karkowski, L, Weinreb, L, Henry, A, Schanz, N, Hahn, E M

“…Infant house mice, Mus musculus, produce ultrasonic calls that reliably lead to retrieval by adult mice. While individual differences in calls have been…”
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Cytochrome P4501A induction and porphyrin accumulation in PLHC-1 fish cells exposed to sediment and oil shale extracts by Huuskonen, S.E, Tuvikene, A, Trapido, M, Fent, K, Hahn, M.E

“…The present study describes the use of a fish hepatoma cell line (PLHC-1) in monitoring the biological effects of sediments collected from recipient waters of…”
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Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian by Karchner, S.I., Kennedy, S.W., Trudeau, S., Hahn, M.E.

“…2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) and related planar halogenated aromatic hydrocarbons (PHAHs) are highly toxic to most vertebrate animals, but there…”
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Biological Activity and Physicochemical Parameters of Marine Halogenated Natural Products 2,3,3′,4,4′,5,5′-Heptachloro-1′-Methyl-1,2′-Bipyrrole and2,4,6-Tribromoanisole by Vetter, W., Hahn, M. E., Tomy, G., Ruppe, S., Vatter, S., Chahbane, N., Lenoir, D., Schramm, K.-W., Scherer, G.

“…Physicochemical parameters (vapor pressure, water solubility, Henry's law constant) and biological activities of two halogenated natural products frequently…”
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The evolution of aryl hydrocarbon signaling proteins: diversity of ARNT isoforms among fish species by Powell, W.H, Hahn, M.E

“…The aryl hydrocarbon receptor nuclear translocator (ARNT) mediates aryl hydrocarbon signaling and toxicity by dimerizing with the ligand-activated aryl…”
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