Search Results - "Hahlen, K"

Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome by KLUSMANN, J. H, REINHARDT, D, HASLE, H, KASPERS, G. J, CREUTZIG, U, HAHLEN, K, VAN DEN HEUVEL-EIBRINK, M. M, ZWAAN, C. M

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Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples by CLOOS, J, GOEMANS, B. F, CREUTZIG, U, SCHUURHUIS, G. J, ZWAAN, Ch. M, KASPERS, G. J. L, HESS, C. J, VAN OOSTVEEN, J. W, WAISFISZ, Q, CORTHALS, S, DE LANGE, D, BOECKX, N, HÄHLEN, K, REINHARDT, D

“…In acute myeloid leukemia (AML), activating mutations in the fms-like tyrosine kinase 3 (FLT3) gene predict poor prognosis. We determined FLT3 internal tandem…”
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Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia by GOEMANS, B. F, ZWAAN, Ch. M, KASPERS, G. J. L, HEINRICH, M. C, MILLER, M, ZIMMERMANN, M, HARLOW, A, MESHINCHI, S, LOONEN, A. H, HIHLEN, K, REINHARDT, D, CREUTZIG, U

“…Activating mutations in RAS and receptor tyrosine kinases such as KIT and FLT3 are hypothesized to cooperate with chimeric transcription factors in the…”
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Causes of death - other than progressive leukemia - in childhood acute lymphoblastic (ALL) and myeloid leukemia (AML): the Dutch Childhood Oncology Group experience by SLATS, A. M, EGELER, R. M, VAN DER DOES-VAN DEN BERG, A, KORBIJN, C, HÄHLEN, K, KAMPS, W. A, VEERMAN, A. J. P, ZWAAN, C. M

“…We analyzed causes of death, other than resistant disease or relapse, in 875 children with acute lymphoblastic leukemia (ALL) and 229 with acute myeloid…”
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Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR by VAN DER VELDEN, V. H. J, WILLEMSE, M. J, VAN DER SCHOOT, C. E, HÄHLEN, K, VAN WERING, E. R, VAN DONGEN, J. J. M

“…Immunoglobulin gene rearrangements are used as PCR targets for detection of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL). We…”
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Large interindividual differences in cellular sensitivity to calicheamicin may influence gemtuzumab ozogamicin response in acute myeloid leukemia by Goemans, B F, Zwaan, C M, Vijverberg, S J H, Loonen, A H, Creutzig, U, Hählen, K, Reinhardt, D, Gibson, B E S, Cloos, J, Kaspers, G J L

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Treatment strategy and results in children treated on three Dutch Childhood Oncology Group acute myeloid leukemia trials by Kardos, G, Zwaan, C M, Kaspers, G J L, de-Graaf, S S N, de Bont, E S J M, Postma, A, Bökkerink, J P M, Weening, R S, van der Does-van den Berg, A, van Wering, E R, Korbijn, C, Hählen, K

“…This report describes the long-term follow-up data of three consecutive Dutch Childhood Oncology Group acute myeloid leukemia (AML) protocols. A total of 303…”
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Minimal residual disease levels in bone marrow and peripheral blood are comparable in children with T cell acute lymphoblastic leukemia (ALL), but not in precursor-B-ALL by VAN DER VELDEN, V. H. J, JACOBS, D. C. H, WIJKHUIJS, A. J. M, COMANS-BITTER, W. M, WILLEMSE, M. J, HÄHLEN, K, KAMPS, W. A, VAN WERING, E. R, VAN DONGEN, J. J. M

“…Sensitive and quantitative detection of minimal residual disease (MRD) in bone marrow (BM) samples of children with acute lymphoblastic leukemia (ALL) is…”
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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia by Licht, Jonathan D, Gelb, Bruce D, Jung, Andreas, Fragale, Alessandra, Song, Xiaoling, Buechner, Jochen, Niemeyer, Charlotte M, Tartaglia, Marco, Hählen, Karel, Hasle, Henrik

“…We report here that individuals with Noonan syndrome and juvenile myelomonocytic leukemia (JMML) have germline mutations in PTPN11 and that somatic mutations…”
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TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia by WOERDEN, N. L. R.-V, PIETERS, R, HÄHLEN, K, SCHMIEGELOW, K, JANKA-SCHAUB, G. E, VEERMAN, A. J. P, LOONEN, A. H, HUBEEK, I, VAN DRUNEN, E, BEVERLOO, H. B, SLATER, R. M, HARBOTT, J, SEYFARTH, J, VAN WERING, E. R

“…The t(12;21) translocation resulting in TEL/AML1 gene fusion is present in approximately 25% of patients with precursor B-lineage pediatric acute lymphoblastic…”
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High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia. Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group by Veerman, A J, Hählen, K, Kamps, W A, Van Leeuwen, E F, De Vaan, G A, Solbu, G, Suciu, S, Van Wering, E R, Van der Does-Van der Berg, A

“…Here we report the results of a nationwide cooperative study in the Netherlands on acute lymphoblastic leukemia (ALL) in children. The aim of the study was to…”
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Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias : alternative PCR targets for detection of minimal residual disease by SZCZEPANSKI, T, BEISHUIZEN, A, PONGERS-WILLEMSE, M. J, HÄHLEN, K, VAN WERING, E. R, WIJKHUIJS, A. J. M, TIBBE, G. J. M, DE BRUIJN, M. A. C, VAN DONGEN, J. J. M

“…A large series of 202 childhood precursor-B cell acute lymphoblastic leukemia (ALL) patients was analyzed by Southern blotting (SB) for cross-lineage…”
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Gemtuzumab ozogamicin in pediatric CD33-positive acute lymphoblastic leukemia: first clinical experiences and relation with cellular sensitivity to single agent calicheamicin by Zwaan, C M, Reinhardt, D, Jürgens, H, Huismans, D R, Hählen, K, Smith, O P, Biondi, A, van Wering, E R, Feingold, J, Kaspers, G J L

“…LEUKEMIA: (2003) 17, 468-470. doi:10.1038/sj.leu.2402749…”
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Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia by Zwaan, Christian M., Kaspers, Gert-Jan L., Pieters, Rob, Woerden, Nicole L. Ramakers-Van, den Boer, Monique L., Wünsche, Renate, Rottier, Maria M.A., Hählen, Karel, van Wering, Elizabeth R., Janka-Schaub, Gritta E., Creutzig, Ursula, Veerman, Anjo J.P.

“…Determining in vitro drug resistance may reveal clinically relevant information in childhood leukemia. Using the methyl-thiazol-tetrazolium assay, the…”
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A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia by Goemans, BF, Zwaan, CM, Reinhardt, D, Gibson, BE, Hahlen, K, Kaspers, GJ

“…Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially…”
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Extramedullary infiltrates at diagnosis have no prognostic significance in children with acute myeloid leukaemia by BISSCHOP, M. M, REVESZ, T, BIERINGS, M, VAN WEERDEN, J. F, VAN WERING, E. R, HÄHLEN, K, VAN DER DOES-VAN DEN BERG, A

“…This retrospective study was designed to review the relative frequency and prognostic significance of extramedullary infiltrates in children with acute myeloid…”
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Differences in the prevalence of PTPN11 mutations in FAB M5 paediatric acute myeloid leukaemia by Goemans, B. F., Zwaan, Ch. M., Martinelli, S., Harrell, P., Lange, D., Carta, C., Reinhardt, D., Hählen, K., Creutzig, U., Tartaglia, M., Heinrich, M. C., Kaspers, G. J. L.

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Intensive Treatment of Children With Acute Lymphoblastic Leukemia According to ALL-BFM-86 Without Cranial Radiotherapy: Results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-1991) by Kamps, W.A., Bökkerink, J.P.M., Hählen, K., Hermans, J., Riehm, H., Gadner, H., Schrappe, M., Slater, R., van den Berg-de Ruiter, E., Smets, L.A., de Vaan, G.A.M., Weening, R.S., van Weerden, J.F., van Wering, E.R., den Berg, A. van der Does-van

“…In The Netherlands from July 1988 to October 1991, children (0 to 16 years of age) with de novo acute lymphoblastic leukemia (ALL) were treated according to…”
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Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy by VAN LOCHEM, E. G, WIEGERS, Y. M, VAN DEN BEEMD, R, HÄHLEN, K, VAN DONGEN, J. J. M, HOOIJKAAS, H

“…Immunofluorescence stainings for the CD10 antigen and terminal deoxynucleotidyl transferase (TdT) can be used for the detection of leukemic blasts in CD10+…”
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Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia by KAAIJK, P, KASPERS, G. J. L, VEERMAN, A. J. P, VAN WERING, E. R, BROEKEMA, G. J, LOONEN, A. H, HÄHLEN, K, SCHMIEGELOW, K, JANKA-SCHAUB, G. E, HENZE, G, CREUTZIG, U

“…Bone marrow and peripheral blood samples from 362 patients with acute lymphoblastic leukaemia (ALL) proliferating cell and 90 patients with acute myeloid…”
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