Search Results - "Hagman, James R"

GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers by Li, Yapeng, Gao, Junfeng, Kamran, Mohammad, Harmacek, Laura, Danhorn, Thomas, Leach, Sonia M., O’Connor, Brian P., Hagman, James R., Huang, Hua

“…Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors…”
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EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene by Somasundaram, Rajesh, Jensen, Christina T., Tingvall-Gustafsson, Johanna, Åhsberg, Josefine, Okuyama, Kazuki, Prasad, Mahadesh, Hagman, James R., Wang, Xun, Soneji, Shamit, Strid, Tobias, Ungerbäck, Jonas, Sigvardsson, Mikael

“…Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant…”
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Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation by Li, Cang, Wang, Zhengyu, Yao, Licheng, Lin, Xingyu, Jian, Yongping, Li, Yujia, Zhang, Jie, Shao, Jingwei, Tran, Phuc D., Hagman, James R., Cao, Meng, Cong, Yusheng, Li, Hong-yu, Goding, Colin R., Xu, Zhi-Xiang, Liao, Xuebin, Miao, Xiao, Cui, Rutao

“…Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit…”
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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis by Hernandez, Giovanny, Mills, Taylor S, Rabe, Jennifer L, Chavez, James S, Kuldanek, Susan, Kirkpatrick, Gregory, Noetzli, Leila, Jubair, Widian K, Zanche, Michelle, Myers, Jason R, Stevens, Brett M, Fleenor, Courtney J, Adane, Biniam, Dinarello, Charles A, Ashton, John, Jordan, Craig T, Di Paola, Jorge, Hagman, James R, Holers, V Michael, Kuhn, Kristine A, Pietras, Eric M

“…Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also…”
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The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis by Wang, Meiqin, MD, PhD, Ramirez, Julita, DVM, PhD, Han, Junyan, PhD, Jia, Yi, PhD, Domenico, Joanne, BS, Seibold, Max A., PhD, Hagman, James R., PhD, Gelfand, Erwin W., MD

“…Background Cytochrome P450, family 11, subfamily A, polypeptide 1 (Cyp11a1), a cytochrome P450 enzyme, is the first and rate-limiting enzyme in the…”
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Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination by Hagman, James R., Arends, Tessa, Laborda, Curtis, Knapp, Jennifer R., Harmacek, Laura, O’Connor, Brian P.

“…Summary B lymphocytes develop from uncommitted precursors into immunoglobulin (antibody)‐producing B cells, a major arm of adaptive immunity. Progression of…”
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CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis by Arends, Tessa, Dege, Carissa, Bortnick, Alexandra, Danhorn, Thomas, Knapp, Jennifer R., Jia, Haiqun, Harmacek, Laura, Fleenor, Courtney J., Straign, Desiree, Walton, Kendra, Leach, Sonia M., Feeney, Ann J., Murre, Cornelis, O’Connor, Brian P., Hagman, James R.

“…Cell lineage specification is a tightly regulated process that is dependent on appropriate expression of lineage and developmental stage-specific…”
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α1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages by Bai, Xiyuan, Bai, An, Tomasicchio, Michele, Hagman, James R, Buckle, Ashley M, Gupta, Arnav, Kadiyala, Vineela, Bevers, Shaun, Serban, Karina A, Kim, Kevin, Feng, Zhihong, Spendier, Kathrin, Hagen, Guy, Fornis, Lorelenn, Griffith, David E, Dzieciatkowska, Monika, Sandhaus, Robert A, Gerber, Anthony N, Chan, Edward D

“…α1-Antitrypsin (AAT), a serine protease inhibitor, is the third most abundant protein in plasma. Although the best-known function of AAT is irreversible…”
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Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment by Fleenor, Courtney J., Arends, Tessa, Lei, Hong, Åhsberg, Josefine, Okuyama, Kazuki, Kuruvilla, Jacob, Cristobal, Susana, Rabe, Jennifer L., Pandey, Ahwan, Danhorn, Thomas, Straign, Desiree, Espinosa, Joaquin M., Warming, Søren, Pietras, Eric M., Sigvardsson, Mikael, Hagman, James R.

“…Zinc finger protein 521 (ZFP521), a DNA-binding protein containing 30 Krüppel-like zinc fingers, has been implicated in the differentiation of multiple cell…”
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Abstract 2000: ETV6 represses Pax5 in early B-cell development by Jones, Courtney L., Fleenor, Courtney J., Welsh, Seth, Noetzli, Leila, Fosmire, Susan, Baturin, Dmitry, Di Paola, Jorge, Hagman, James R., Porter, Christopher C.

“…The goal of this project is to determine the role of ETV6 in early B cell development and define how germline ETV6 mutations result in predisposition to…”
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Fusion of Early B Cell Factor 1 with Platelet-Derived Growth Factor Receptor Beta in B-ALL disrupts functions necessary for normal B lymphopoiesis by Hagman, James R, Welsh, Seth J

“…Human B cell Acute Lymphoblastic Leukemia (B-ALL) cells often lack functional genes encoding Early B cell Factor 1 (EBF1). EBF1 is essential for B lineage…”
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Alpha-1-antitrypsin binds to the glucocorticoid receptor with anti-inflammatory and anti-mycobacterial significance in macrophages by Bai, Xiyuan, Bai, An, Tomasicchio, Michele, Hagman, James R., Buckle, Ashley M., Gupta, Arnav, Kadiyala, Vineela, Bevers, Shaun, Serban, Karina A., Kim, Kevin, Feng, Zhihong, Spendier, Kathrin, Hagen, Guy, Fornis, Lorelenn, Griffith, David E., Dzieciatkowska, Monika, Sandhaus, Robert A., Gerber, Anthony N., Chan, Edward D.

“…Alpha-1-antitrypsin (AAT), a serine protease inhibitor, is the third most abundant protein in plasma. While the best-known function of AAT is irreversible…”
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Control of T cell development and function by Protein Arginine Methyltransferase 5 by Hagman, James R., Fleenor, Courtney J., Arends, Tessa, Pandey, Ahwan, Abraham, Christopher G., Dege, Carissa L., Straign, Desiree, Danhorn, Thomas, Reinhardt, R. Lee, Espinosa, Joaquin M., O’Connor, Brian P.

“…Temporally and spatially regulated gene expression is essential for the development of thymocytes and functional T cells. Gene transcription is controlled, in…”
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ETV6 Regulates Pax5 Expression in Early B Cell Development by Jones, Courtney L., Kirkpatrick, Gregory, Fleenor, Courtney, Seth, Welsh, Noetzli, Leila J, Fosmire, Susan, Baturin, Dmitry, Liang, Xiayuan, Hernandez, Giovanny, Pietras, Eric Martin, Jordan, Craig T, Rowley, Jesse W, Di Paola, Jorge, Hagman, James R., Porter, Christopher C.

“…Recent studies from our group and others have revealed a role for ETV6 germline mutations in the predisposition to ALL. Although ETV6 is among the most…”
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Neuroimaging Findings in Patients with EBF3 Mutations: Report of Two Cases by Jiménez de la Peña, Mar, Jiménez de Domingo, Ana, Tirado, Pilar, Calleja-Pérez, Beatriz, Alcaraz, Luis A., Álvarez, Sara, Williams, Jonathan, Hagman, James R., Németh, Andrea H., Fernández-Jaén, Alberto

“…Early B cell factor 3 (EBF3) is a transcription factor involved in brain development. Heterozygous, loss-of-function mutations in EBF3 have been reported in an…”
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Neuroimaging Findings in Patients with EBF3 Mutations: Report of Two Cases by Jiménez de la Peña, Mar, Jiménez de Domingo, Ana, Tirado, Pilar, Calleja-Pérez, Beatriz, Alcaraz, Luis A, Álvarez, Sara, Williams, Jonathan, Hagman, James R, Németh, Andrea H, Fernández-Jaén, Alberto

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