Search Results - "Hagl, Stephanie"

Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing by Eckert, Gunter P., Chang, Steffi, Eckmann, Janett, Copanaki, Ekaterini, Hagl, Stephanie, Hener, Uwe, Müller, Walter E., Kögel, Donat

“…The fluidity of neuronal membranes plays a pivotal role in brain aging and neurodegeneration. In this study, we investigated the role of the omega-3 fatty acid…”
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Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice by Hagl, Stephanie, Berressem, Dirk, Grewal, Rehka, Sus, Nadine, Frank, Jan, Eckert, Gunter P.

“…Objectives: Aging represents a major risk factor for neurodegenerative diseases such as Alzheimer's disease. Mitochondria are significantly involved in both…”
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Impact of Silibinin A on Bioenergetics in PC12APPsw Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria by Esselun, Carsten, Bruns, Bastian, Hagl, Stephanie, Grewal, Rekha, Eckert, Gunter P.

“…Age-related multifactorial diseases, such as the neurodegenerative Alzheimer’s disease (AD), still remain a challenge to today’s society. One mechanism…”
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MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease by Pohland, Maximilian, Pellowska, Maren, Asseburg, Heike, Hagl, Stephanie, Reutzel, Martina, Joppe, Aljoscha, Berressem, Dirk, Eckert, Schamim H, Wurglics, Mario, Schubert-Zsilavecz, Manfred, Eckert, Gunter P

“…Current approved drugs for Alzheimer's disease (AD) only attenuate symptoms, but do not cure the disease. The pirinixic acid derivate MH84 has been…”
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Effects of Grape Skin Extract on Age-Related Mitochondrial Dysfunction, Memory and Life Span in C57BL/6J Mice by Asseburg, Heike, Schäfer, Carmina, Müller, Madeleine, Hagl, Stephanie, Pohland, Maximilian, Berressem, Dirk, Borchiellini, Marta, Plank, Christina, Eckert, Gunter P.

“…Dementia contributes substantially to the burden of disability experienced at old age, and mitochondrial dysfunction (MD) was identified as common final…”
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Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components by Hagl, Stephanie, Berressem, Dirk, Bruns, Bastian, Sus, Nadine, Frank, Jan, Eckert, Gunter P

“…Mitochondria are involved in the aging processes that ultimately lead to neurodegeneration and the development of Alzheimer's disease (AD). A healthy…”
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Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice by Hagl, Stephanie, Asseburg, Heike, Heinrich, Martina, Sus, Nadine, Blumrich, Eva-Maria, Dringen, Ralf, Frank, Jan, Eckert, Gunter P.

“…Aging represents a major risk factor for the development of neurodegenerative diseases like Alzheimer’s disease (AD). As mitochondrial dysfunction plays an…”
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Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice by Kocher, Alexa, Hagl, Stephanie, Schiborr, Christina, Eckert, Gunter P., Frank, Jan

“…Curcuminoids (curcumin, demethoxycurcumin, bis-demethoxycurcumin) are lipophilic polyphenols thought to be effective in the prevention and treatment of…”
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Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice – Impact on bioavailability by Hagl, Stephanie, Kocher, Alexa, Schiborr, Christina, Kolesova, Natalie, Frank, Jan, Eckert, Gunter P.

“…Curcumin, a polyphenolic compound abundant in the rhizome of Curcuma longa, has been reported to have various beneficial biological and pharmacological…”
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Olesoxime improves cerebral mitochondrial dysfunction and enhances Aβ levels in preclinical models of Alzheimer's disease by Eckert, Gunter P., Eckert, Schamim H., Eckmann, Janett, Hagl, Stephanie, Muller, Walter E., Friedland, Kristina

“…Approved drugs for Alzheimer's disease (AD) only have a symptomatic effects and do not intervene causally in the course of the disease. Olesoxime (TRO19622)…”
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Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway by Bhatia, Harsharan S, Baron, Julian, Hagl, Stephanie, Eckert, Gunter P, Fiebich, Bernd L

“…Hyperactivation of microglia is considered to be a key hallmark of brain inflammation and plays a critical role in regulating neuroinflammatory events…”
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Differential Effects of Silibinin A on Mitochondrial Function in Neuronal PC12 and HepG2 Liver Cells by Grewal, Rekha, Hagl, Stephanie, Bruns, Bastian, Esselun, Carsten, Eckert, Gunter P.

“…The Mediterranean plant Silybum marianum L., commonly known as milk thistle, has been used for centuries to treat liver disorders. The flavonolignan silibinin…”
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Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8 by Eckert, Gunter P., Schiborr, Christina, Hagl, Stephanie, Abdel-Kader, Reham, Müller, Walter E., Rimbach, Gerald, Frank, Jan

“…► Mitochondrial dysfunction and reduced energy production occur in the aging brain. ► We studied if SAMP8 vs. SAMR1 mice can be used as a model for…”
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Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease by Eckert, Gunter P., Renner, Kathrin, Eckert, Schamim H., Eckmann, Janett, Hagl, Stephanie, Abdel-Kader, Reham M., Kurz, Christopher, Leuner, Kristina, Muller, Walter E.

“…Increasing evidences suggest that mitochondrial dysfunction plays an important role in the pathogenesis of neurodegenerative diseases including Alzheimer's…”
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Rice bran extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer's disease by Hagl, Stephanie, Grewal, Rekha, Ciobanu, Ion, Helal, Amr, Khayyal, Mohamed T, Muller, Walter E, Eckert, Gunter P

“…Mitochondrial dysfunction plays an important role in brain aging and has emerged to be an early event in Alzheimer's disease (AD), contributing to…”
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Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging – Impact of Bcl-2 and NPD-1 like metabolites by Afshordel, Sarah, Hagl, Stephanie, Werner, Deborah, Röhner, Nelli, Kögel, Donat, Bazan, Nicolas G, Eckert, Gunter P

“…Abstract The present study investigated the effects of orally administered long chain omega-3 polyunsaturated fatty acids (PUFA) on mitochondrial function and…”
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MH84: A Novel γ-Secretase Modulator/PPARγ Agonist—Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease by Pohland, Maximilian, Hagl, Stephanie, Pellowska, Maren, Wurglics, Mario, Schubert-Zsilavecz, Manfred, Eckert, Gunter P.

“…Developing new therapeutic strategies for Alzheimer’s disease (AD) is a current challenge. Approved drugs merely act symptomatically and delay the progression…”
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Colonic availability of polyphenols and D-(−)-quinic acid after apple smoothie consumption by Hagl, Stephanie, Deusser, Hannah, Soyalan, Buelent, Janzowski, Christine, Will, Frank, Dietrich, Helmut, Albert, Franz Werner, Rohner, Simone, Richling, Elke

“…Scope: The aim of this study was to determine the amounts of polyphenols and D-(−)-quinic acid reaching the ileostomy bags of probands (and thus the colon in…”
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Rice bran extract protects from mitochondrial dysfunction in guinea pig brains by Hagl, Stephanie, Kocher, Alexa, Schiborr, Christina, Eckert, Schamim H., Ciobanu, Ion, Birringer, Marc, El-Askary, Hesham, Helal, Amr, Khayyal, Mohamed T., Frank, Jan, Muller, Walter E., Eckert, Gunter P.

“…Mitochondrial dysfunction plays a major role in the development of age-related neurodegenerative diseases and recent evidence suggests that food ingredients…”
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MH84: A Novel [gamma]-Secretase Modulator/PPAR[gamma] Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease by Pohland, Maximilian, Hagl, Stephanie, Pellowska, Maren, Wurglics, Mario, Schubert-zsilavecz, Manfred, Eckert, Gunter P

“…Issue Title: Special Issue: 40th Year of Neurochemical Research Developing new therapeutic strategies for Alzheimer's disease (AD) is a current challenge…”
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