Search Results - "Hagiwara, Keitaro"

Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs by Kosaka, Nobuyoshi, Iguchi, Haruhisa, Yoshioka, Yusuke, Hagiwara, Keitaro, Takeshita, Fumitaka, Ochiya, Takahiro

“…Normal epithelial cells regulate the secretion of autocrine and paracrine factors that prevent aberrant growth of neighboring cells, leading to healthy…”
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The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer by Fujita, Yu, Yagishita, Shigehiro, Hagiwara, Keitaro, Yoshioka, Yusuke, Kosaka, Nobuyoshi, Takeshita, Fumitaka, Fujiwara, Tomohiro, Tsuta, Koji, Nokihara, Hiroshi, Tamura, Tomohide, Asamura, Hisao, Kawaishi, Makoto, Kuwano, Kazuyoshi, Ochiya, Takahiro

“…Programmed cell death ligand-1 (PD-L1) has recently gained considerable attention for its role in tumor immune escape. Here, we identify a…”
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MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion by Yasukawa, Ken, Liew, Lee Chuen, Hagiwara, Keitaro, Hironaka‐Mitsuhashi, Ai, Qin, Xian‐Yang, Furutani, Yutaka, Tanaka, Yasuhito, Nakagama, Hitoshi, Kojima, Soichi, Kato, Takashi, Ochiya, Takahiro, Gailhouste, Luc

“…Primary hepatic tumors mainly include hepatocellular carcinoma (HCC), which is one of the most frequent causes of cancer‐related deaths worldwide. Thus far,…”
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RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy by Tominaga, Naoomi, Hagiwara, Keitaro, Kosaka, Nobuyoshi, Honma, Kimi, Nakagama, Hitoshi, Ochiya, Takahiro

“…The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to…”
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miR‐148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells by Gailhouste, Luc, Gomez‐Santos, Laura, Hagiwara, Keitaro, Hatada, Izuho, Kitagawa, Noriyuki, Kawaharada, Kazushi, Thirion, Muriel, Kosaka, Nobuyoshi, Takahashi, Ryou‐u, Shibata, Tatsuhiro, Miyajima, Atsushi, Ochiya, Takahiro

“…MicroRNAs (miRNAs) are evolutionary conserved small RNAs that post‐transcriptionally regulate the expression of target genes. To date, the role of miRNAs in…”
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miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells by Aida, Rieko, Hagiwara, Keitaro, Okano, Kazunori, Nakata, Kyoko, Obata, Yuho, Yamashita, Takahiro, Yoshida, Kaoru, Hagiwara, Hiromi

“…Apigenin is a flavonoid with antioxidant and anticancer effects. It has been reported that apigenin inhibits proliferation, migration, and invasion and induces…”
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Clinical Relevance and Therapeutic Significance of MicroRNA‐133a Expression Profiles and Functions in Malignant Osteosarcoma‐Initiating Cells by Fujiwara, Tomohiro, Katsuda, Takeshi, Hagiwara, Keitaro, Kosaka, Nobuyoshi, Yoshioka, Yusuke, Takahashi, Ryou‐U, Takeshita, Fumitaka, Kubota, Daisuke, Kondo, Tadashi, Ichikawa, Hitoshi, Yoshida, Akihiko, Kobayashi, Eisuke, Kawai, Akira, Ozaki, Toshifumi, Ochiya, Takahiro

“…Novel strategies against treatment‐resistant tumor cells remain a challenging but promising therapeutic approach. Despite accumulated evidence suggesting the…”
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Functional analysis of exosomal microRNA in cell-cell communication research by Kosaka, Nobuyoshi, Yoshioka, Yusuke, Hagiwara, Keitaro, Tominaga, Naoomi, Ochiya, Takahiro

“…Circulating microRNAs (miRNAs), also known as secretory miRNAs, are packaged in small membrane vesicles called exosomes. These exosomal miRNAs are secreted…”
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Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy by Kosaka, Nobuyoshi, Yoshioka, Yusuke, Tominaga, Naoomi, Hagiwara, Keitaro, Katsuda, Takeshi, Ochiya, Takahiro

“…Cell-cell communication is essential for the regulation of various biological phenomena in multicellular organisms, including development and homeostasis…”
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Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors by Ishikawa, Tetsuya, Kobayashi, Momoko, Yanagi, Satoshi, Kato, Chika, Takashima, Ryokichi, Kobayashi, Eiji, Hagiwara, Keitaro, Ochiya, Takahiro

“…Preparing targeted cells for medical applications from human induced pluripotent stem cells (hiPSCs) using growth factors, compounds, or gene transfer has been…”
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Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells by Ishikawa, Tetsuya, Banas, Agnieszka, Hagiwara, Keitaro, Iwaguro, Hideki, Ochiya, Takahiro

“…Severe hepatic dysfunctions including hepatic cirrhosis and hepatocarcinoma are life-threatening conditions for which effective medical treatments are needed…”
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Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice by Goto, Tadashi, Hagiwara, Keitaro, Shirai, Nobuaki, Yoshida, Kaoru, Hagiwara, Hiromi

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Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment by Gailhouste, Luc, Liew, Lee Chuen, Yasukawa, Ken, Hagiwara, Keitaro, Iwazaki, Norihiko, Yamada, Yasuhiro, Hatada, Izuho, Ochiya, Takahiro

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A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications by Hagiwara, Keitaro, Ochiya, Takahiro, Kosaka, Nobuyoshi

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Nephrotoxic effect of subchronic exposure to S-(1,2-dichlorovinyl)-L-cysteine in mice by Shirai, Nobuaki, Ohtsuji, Mareki, Hagiwara, Keitaro, Tomisawa, Hiroki, Ohtsuji, Naomi, Hirose, Sachiko, Hagiwara, Hiromi

“…The effect of subchronic exposure of S-(1,2-dichlorovinyl)-L-cysteine (DCVC), an active metabolite of trichloroethylene (TCE), was investigated in mice, as a…”
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Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis by Kosaka, Nobuyoshi, Iguchi, Haruhisa, Hagiwara, Keitaro, Yoshioka, Yusuke, Takeshita, Fumitaka, Ochiya, Takahiro

“…The release of humoral factors between cancer cells and the microenvironmental cells is critical for metastasis; however, the roles of secreted miRNAs in…”
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Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles by Hagiwara, Keitaro, Katsuda, Takeshi, Gailhouste, Luc, Kosaka, Nobuyoshi, Ochiya, Takahiro

“…•ANXA2 silencing is highly efficient for decreasing EV miRNA abundance.•Overexpression of ANXA2 increases the total amount of miRNAs in EVs.•ANXA2 regulates EV…”
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Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity by Katsuda, Takeshi, Kawamata, Masaki, Hagiwara, Keitaro, Takahashi, Ryou-u, Yamamoto, Yusuke, Camargo, Fernando D., Ochiya, Takahiro

“…A challenge for advancing approaches to liver regeneration is loss of functional differentiation capacity when hepatocyte progenitors are maintained in…”
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Olive polyphenol hydroxytyrosol prevents bone loss by Hagiwara, Keitaro, Goto, Tadashi, Araki, Masahiro, Miyazaki, Hitoshi, Hagiwara, Hiromi

“…Polyphenols reportedly exert physiological effects against diseases such as cancer, arteriosclerosis, hyperlipidemia and osteoporosis. The present study was…”
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Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity by Hagiwara, Keitaro, Kosaka, Nobuyoshi, Yoshioka, Yusuke, Takahashi, Ryou-u, Takeshita, Fumitaka, Ochiya, Takahiro

“…It is well known that natural products are a rich source of compounds for applications in medicine, pharmacy and biology. However, the exact molecular…”
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