Search Results - "Hagita, Sumihiko"

Time course of histopathology of bleomycin-induced pulmonary fibrosis using an intratracheal sprayer in mice by Kobayashi, Hideyuki, Tachi, Ayami, Hagita, Sumihiko

“…Idiopathic pulmonary fibrosis (IPF) is a poor prognosis disease that affects approximately 5 million people worldwide, and the detailed mechanisms underlying…”
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Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation by Hagita, Sumihiko, Osaka, Mizuko, Shimokado, Kentaro, Yoshida, Masayuki

“…Although inflammation within adipose tissues is known to play a role in metabolic syndrome, the causative connection between inflamed adipose tissue and…”
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Mechanism of lipid‐lowering action of the dipeptidyl peptidase‐4 inhibitor, anagliptin, in low‐density lipoprotein receptor‐deficient mice by Yano, Wataru, Inoue, Noriyuki, Ito, Shiori, Itou, Takahiro, Yasumura, Misako, Yoshinaka, Yasunobu, Hagita, Sumihiko, Goto, Moritaka, Nakagawa, Takashi, Inoue, Keisuke, Tanabe, Sohei, Kaku, Kohei

“…Aims/Introduction Dipeptidyl peptidase‐4 inhibitors are used for treatment of patients with type 2 diabetes. In addition to glycemic control, these agents…”
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In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin by Osaka, Mizuko, Yoshida, Masayuki, Hagita, Sumihiko

“…To monitor the anti-inflammatory effect of rosuvastatin in leukocyte endothelial interactions in the atheroprone femoral artery in vivo. Methods and Results…”
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Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery by Hagita, Sumihiko, Osaka, Mizuko, Shimokado, Kentaro, Yoshida, Masayuki

“…Recent studies have demonstrated a potential synergistic effect of the combination of amlodipine with atorvastatin to reduce acute inflammation. The…”
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Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation by Osaka, Mizuko, Hagita, Sumihiko, Haraguchi, Mihoko, Kajimura, Mayumi, Suematsu, Makoto, Yoshida, Masayuki

“…Wire injury of an artery has been recognized as a standard model of vascular inflammation and atherosclerosis; however, the mechanism of leukocyte recruitment…”
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Time course of histopathology of bleomycin-induced pulmonary fibrosis using an intratracheal sprayer in mice by KOBAYASHI, Hideyuki, TACHI, Ayami, HAGITA, Sumihiko

“…Idiopathic pulmonary fibrosis (IPF) is a poor prognosis disease that affects approximately 5 million people worldwide, and the detailed mechanisms underlying…”
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Sortilin mediates vascular calcification via its recruitment into extracellular vesicles by Goettsch, Claudia, Hutcheson, Joshua D, Aikawa, Masanori, Iwata, Hiroshi, Pham, Tan, Nykjaer, Anders, Kjolby, Mads, Rogers, Maximillian, Michel, Thomas, Shibasaki, Manabu, Hagita, Sumihiko, Kramann, Rafael, Rader, Daniel J, Libby, Peter, Singh, Sasha A, Aikawa, Elena

“…Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that…”
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A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification by Goettsch, Claudia, Hutcheson, Joshua D, Hagita, Sumihiko, Rogers, Maximillian A, Creager, Michael D, Pham, Tan, Choi, Jung, Mlynarchik, Andrew K, Pieper, Brett, Kjolby, Mads, Aikawa, Masanori, Aikawa, Elena

“…Abstract Background and aims Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that…”
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Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity by Iqbal, Farwah, Schlotter, Florian, Becker-Greene, Dakota, Lupieri, Adrien, Goettsch, Claudia, Hutcheson, Joshua D, Rogers, Maximillian A, Itoh, Shinsuke, Halu, Arda, Lee, Lang Ho, Blaser, Mark C, Mlynarchik, Andrew K, Hagita, Sumihiko, Kuraoka, Shiori, Chen, Hao Yu, Engert, James C, Passos, Livia S A, Jha, Prabhash K, Osborn, Eric A, Jaffer, Farouc A, Body, Simon C, Robson, Simon C, Thanassoulis, George, Aikawa, Masanori, Singh, Sasha A, Sonawane, Abhijeet R, Aikawa, Elena

“…Abstract Aims Calcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and…”
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Discovery of novel spiro[chromane-2,4′-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists by Koshizawa, Tomoaki, Morimoto, Toshiharu, Watanabe, Gen, Fukuda, Tomoaki, Yamasaki, Nao, Hagita, Sumihiko, Sawada, Yoshikazu, Okuda, Ayumu, Shibuya, Kimiyuki, Ohgiya, Tadaaki

“…[Display omitted] •The spiro-type scaffold was used as a novel linker-to-tail moiety of GPR119 agonists.•The rigid spiro-type scaffold enabled flexible and…”
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Abstract 595: Transcriptional Control of Intestinal Cholesterol Absorption, Adipose Energy Expenditure and Lipid Handling by Sortilin by Hagita, Sumihiko, Rogers, Maximillian, Pham, Tan, Wen, Jennifer, Mlynarchik, Andrew, Aikawa, Masanori, Aikawa, Elena

“…Abstract only Objective: The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and…”
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Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin by Hagita, Sumihiko, Rogers, Maximillian A., Pham, Tan, Wen, Jennifer R., Mlynarchik, Andrew K., Aikawa, Masanori, Aikawa, Elena

“…The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and metabolism contribute to…”
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Abstract 45: Sortilin Regulates Arterial Calcification in Atherosclerotic Mice and Associates With Cardiovascular Risk in Humans by Goettsch, Claudia, Hutcheson, Joshua, Iwata, Hiroshi, Hagita, Sumihiko, Libby, Peter, Aikawa, Masanori, Szulc, Pawel, Aikawa, Elena

“…Abstract only Background: Arterial calcification associates with cardiovascular morbidity and mortality. Human genome-wide association studies linked the SORT1…”
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Abstract 647: Induction of Cardiovascular Calcification in Non-transgenic Mice via a Single Injection of Pcsk9 Adeno-associated Viral Vector by Goettsch, Claudia, Hutcheson, Joshua, Hagita, Sumihiko, Rogers, Maximillian, Choi, Jung, Creager, Michael, Pham, Tan, Mlynarchik, Andrew, Fuglsang Kjolby, Mads, Aikawa, Masanori, Aikawa, Elena

“…Abstract only Background: Studying atherosclerotic calcification in vivo requires mouse models with genetic deletion of low-density lipoprotein receptor (Ldlr)…”
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Oxidative Stress in Mononuclear Cells Plays a Dominant Role in Their Adhesion to Mouse Femoral Artery After Injury by Hagita, Sumihiko, Osaka, Mizuko, Shimokado, Kentaro, Yoshida, Masayuki

“…Leukocyte recruitment plays a pivotal role during inflammation after vascular injury. The importance of oxidative stress in vascular injury and its modulation…”
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Abstract 5104: Direct Observation of Adipose Tissue-induced Leukocyte Recruitment to the Artery Wall: A Direct Link Between Obesity and Atherosclerosis by Hagita, Sumihiko, Osaka, Mizuko, Shimokado, Kentaro, Yoshida, Masayuki

“…Abstract only Background: Though inflammation within adipose tissues play a role in pathogenesis of metabolic syndrome, a causative connection between adipose…”
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