Search Results - "Hagimoto, Naoki"

Anti-Vascular Endothelial Growth Factor Gene Therapy Attenuates Lung Injury and Fibrosis in Mice by Hamada, Naoki, Kuwano, Kazuyoshi, Yamada, Mizuho, Hagimoto, Naoki, Hiasa, Kenichi, Egashira, Kensuke, Nakashima, Nobutaka, Maeyama, Takashige, Yoshimi, Michihiro, Nakanishi, Yoichi

“…Vascular endothelial growth factor (VEGF) is an angiogenesis factor with proinflammatory roles. Flt-1 is one of the specific receptors for VEGF, and soluble…”
Get full text

The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region by Herrero, Raquel, Kajikawa, Osamu, Matute-Bello, Gustavo, Wang, Yi, Hagimoto, Naoki, Mongovin, Steve, Wong, Venus, Park, David R, Brot, Nathan, Heinecke, Jay W, Rosen, Henry, Goodman, Richard B, Fu, Xiaoyun, Martin, Thomas R

“…Acute lung injury (ALI) is a life-threatening condition in critically ill patients. Injury to the alveolar epithelium is a critical event in ALI, and…”
Get full text

TGF-β1 as an Enhancer of Fas-Mediated Apoptosis of Lung Epithelial Cells by Hagimoto, Naoki, Kuwano, Kazuyoshi, Inoshima, Ichiro, Yoshimi, Michihiro, Nakamura, Norio, Fujita, Masaki, Maeyama, Takashige, Hara, Nobuyuki

“…Abstract Transforming growth factor-β1 (TGF-β1) has important roles in lung fibrosis and the potential to induce apoptosis in several types of cells. We…”
Get full text

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis by Kuwano, K, Hagimoto, N, Kawasaki, M, Yatomi, T, Nakamura, N, Nagata, S, Suda, T, Kunitake, R, Maeyama, T, Miyazaki, H, Hara, N

“…The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer…”
Get full text

Protection from Lethal Apoptosis in Lipopolysaccharide-Induced Acute Lung Injury in Mice by a Caspase Inhibitor by Kawasaki, Masayuki, Kuwano, Kazuyoshi, Hagimoto, Naoki, Matsuba, Tokuji, Kunitake, Ritsuko, Tanaka, Takuo, Maeyama, Takashige, Hara, Nobuyuki

“…LPS (lipopolysaccharide) is one of the major factors that induce acute lung injury. Recently, it was reported that LPS induced disseminated endothelial…”
Get full text

Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice by Inoshima, Ichiro, Kuwano, Kazuyoshi, Hamada, Naoki, Hagimoto, Naoki, Yoshimi, Michihiro, Maeyama, Takashige, Takeshita, Akira, Kitamoto, Shiro, Egashira, Kensuke, Hara, Nobuyuki

“…Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory chemokine and may play an important role in the development of pulmonary fibrosis. We examined…”
Get more information

Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor by Kuwano, K, Kunitake, R, Maeyama, T, Hagimoto, N, Kawasaki, M, Matsuba, T, Yoshimi, M, Inoshima, I, Yoshida, K, Hara, N

“…Caspases have been implicated in the effector process of apoptosis in several systems including the Fas-Fas ligand pathway. We previously demonstrated that…”
Get more information

Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen by Hagimoto, N, Kuwano, K, Miyazaki, H, Kunitake, R, Fujita, M, Kawasaki, M, Kaneko, Y, Hara, N

“…Fas antigen is a cell surface protein that mediates apoptosis, and it is expressed in various cells and tissues. Fas ligand binds to its receptor Fas, thus…”
Get full text

The Involvement of Fas-Fas Ligand Pathway in Fibrosing Lung Diseases by Kuwano, Kazuyoshi, Miyazaki, Hiroyuki, Hagimoto, Naoki, Kawasaki, Masayuki, Fujita, Masaki, Kunitake, Ritsuko, Kaneko, Yumi, Hara, Nobuyuki

“…Pulmonary fibrosis begins with alveolitis, which progresses to destruction of lung tissue and excess collagen deposition. This process could be the result of…”
Get full text

Molecular mechanisms of pulmonary fibrosis and current treatment by Kuwano, K, Hagimoto, N, Hara, N

“…Pulmonary fibrosis is a common response to various insults or injuries to the lung. Although there are various initiating factors or causes, the terminal…”
Get more information

Mitochondria-Mediated Apoptosis of Lung Epithelial Cells in Idiopathic Interstitial Pneumonias by Kuwano, Kazuyoshi, Hagimoto, Naoki, Maeyama, Takashige, Fujita, Masaki, Yoshimi, Michihiro, Inoshima, Ichiro, Nakashima, Nobutaka, Hamada, Naoki, Watanabe, Kentaro, Hara, Nobuyuki

“…We previously demonstrated that the up-regulation of p53, Fas, and DNA damage are present in lung epithelial cells from patients with idiopathic interstitial…”
Get full text

Induction of Interleukin-8 Secretion and Apoptosis in Bronchiolar Epithelial Cells by Fas Ligation by Hagimoto, Naoki, Kuwano, Kazuyoshi, Kawasaki, Masayuki, Yoshimi, Michihiro, Kaneko, Yumi, Kunitake, Ritsuko, Maeyama, Takashige, Tanaka, Takuo, Hara, Nobuyuki

“…Epithelial cell injury is the common manifestation of lung injury. Contributing to such injury of epithelial cells is apoptosis. Although apoptosis is part of…”
Get full text

Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis by Inoshima, Ichiro, Kuwano, Kazuyoshi, Hamada, Naoki, Yoshimi, Michihiro, Maeyama, Takashige, Hagimoto, Naoki, Nakanishi, Yoichi, Hara, Nobuyuki

“…Alveolar epithelial cells are known to be present at the primary site of lung damage in pulmonary fibrosis. Apoptosis has been implicated as being involved in…”
Get more information

Endothelial cell apoptosis in lipopolysaccharide-induced lung injury in mice by Fujita, M, Kuwano, K, Kunitake, R, Hagimoto, N, Miyazaki, H, Kaneko, Y, Kawasaki, M, Maeyama, T, Hara, N

“…Studies have shown the importance of apoptosis in vascular injury in vitro. We postulated that apoptosis of the endothelium contributes to vascular injury in…”
Get more information

Expression of apoptosis-regulatory genes in epithelial cells in pulmonary fibrosis in mice by Kuwano, Kazuyoshi, Hagimoto, Naoki, Tanaka, Takuo, Kawasaki, Masayuki, Kunitake, Ritsuko, Miyazaki, Hiroyuki, Kaneko, Yumi, Matsuba, Tokuji, Maeyama, Takashige, Hara, Nobuyuki

“…Up‐regulation of Fas and Fas ligand and excessive apoptosis of bronchiolar and alveolar epithelial cells were identified in bleomycin‐induced pulmonary…”
Get full text

Soluble form of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia by Kuwano, K, Kawasaki, M, Maeyama, T, Hagimoto, N, Nakamura, N, Shirakawa, K, Hara, N

“…The Fas-Fas ligand (FasL) pathway is a representative system of apoptosis-signaling receptor molecules. We previously described that this pathway may play an…”
Get more information

Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12 by Maeyama, T, Kuwano, K, Kawasaki, M, Kunitake, R, Hagimoto, N, Hara, N

“…We previously demonstrated essential roles of the Fas-Fas ligand (FasL) pathway in bleomycin-induced pneumopathy in mice. T lymphocytes and natural killer…”
Get more information

Expression of B7-1, B7-2, and interleukin 12 in bleomycin-induced pneumopathy in mice by Kaneko, Y, Kuwano, K, Hagimoto, N, Miyazaki, H, Kawasaki, M, Fujita, M, Kunitake, R, Maeyama, T, Hara, N

“…The bleomycin-induced pneumopathy involves a T cell-mediated immune response. T cell activation requires both antigen/MHC recognition and costimulatory…”
Get more information

TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells by Hagimoto, Naoki, Kuwano, Kazuyoshi, Inoshima, Ichiro, Yoshimi, Michihiro, Nakamura, Norio, Fujita, Masaki, Maeyama, Takashige, Hara, Nobuyuki

“…Transforming growth factor-beta 1 (TGF-beta 1) has important roles in lung fibrosis and the potential to induce apoptosis in several types of cells. We…”
Get full text

MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis by Yoshida, Koichiro, Kuwano, Kazuyoshi, Hagimoto, Naoki, Watanabe, Kentaro, Matsuba, Tokuji, Fujita, Masaki, Inoshima, Ichiro, Hara, Nobuyuki

“…Three major MAP kinases (MAPKs), including extracellular signal‐regulated kinase (ERK), c‐jun N‐terminal kinase (JNK), and p38 kinase (p38 MAPK), are involved…”
Get full text