Search Results - "Hagimoto, N"

Resistance to Fas-mediated apoptosis in human lung fibroblast by Tanaka, T, Yoshimi, M, Maeyama, T, Hagimoto, N, Kuwano, K, Hara, N

“…The current authors have demonstrated previously that epithelial cell apoptosis, induced by the Fas-Fas ligand pathway, might be involved in fibrosing lung…”
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Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias by Kuwano, K, Nakashima, N, Inoshima, I, Hagimoto, N, Fujita, M, Yoshimi, M, Maeyama, T, Hamada, N, Watanabe, K, Hara, N

“…Lung epithelial cells are a primary target for reactive oxygen species (ROS). ROS can cause oxidative deoxyribonucleic acid modification, such as…”
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Protection from Lethal Apoptosis in Lipopolysaccharide-Induced Acute Lung Injury in Mice by a Caspase Inhibitor by Kawasaki, Masayuki, Kuwano, Kazuyoshi, Hagimoto, Naoki, Matsuba, Tokuji, Kunitake, Ritsuko, Tanaka, Takuo, Maeyama, Takashige, Hara, Nobuyuki

“…LPS (lipopolysaccharide) is one of the major factors that induce acute lung injury. Recently, it was reported that LPS induced disseminated endothelial…”
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Retinoic acid fails to reverse emphysema in adult mouse models by Fujita, M, Ye, Q, Ouchi, H, Nakashima, N, Hamada, N, Hagimoto, N, Kuwano, K, Mason, R J, Nakanishi, Y

“…Background: Previous work has shown that all-trans-retinoic acid reverses elastase induced emphysema in rats. Since there is currently no effective treatment…”
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The role of apoptosis in pulmonary fibrosis by Kuwano, K, Hagimoto, N, Nakanishi, Y

“…Pulmonary fibrosis is a common response to various injuries to the lung. The resolution of a fibroproliferative response after lung injury is key to survival…”
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Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice by Hagimoto, N, Kuwano, K, Nomoto, Y, Kunitake, R, Hara, N

“…The incidence of apoptosis and the expression of Fas antigen (Fas)/Fas ligand (FasL) mRNA in bleomycin-induced pulmonary fibrosis in mice were examined. Male…”
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The p53–Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and non-specific interstitial pneumonia by Nakashima, N, Kuwano, K, Maeyama, T, Hagimoto, N, Yoshimi, M, Hamada, N, Yamada, M, Nakanishi, Y

“…Background: Wild-type p53 is increased during cellular responses to various stresses. Mdm2, which is induced by p53, regulates p53 protein concentrations…”
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The perforin mediated apoptotic pathway in lung injury and fibrosis by Miyazaki, H, Kuwano, K, Yoshida, K, Maeyama, T, Yoshimi, M, Fujita, M, Hagimoto, N, Yoshida, R, Nakanishi, Y

“…Aims: The perforin mediated pathway is the major pathway of cytotoxicity induced by activated T cells and natural killer cells, and may be involved in the…”
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Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis by Maeyama, T, Kuwano, K, Kawasaki, M, Kunitake, R, Hagimoto, N, Matsuba, T, Yoshimi, M, Inoshima, I, Yoshida, K, Hara, N

“…The caspase cascade is an executioner of apoptosis, mediated by Fas. Fas-associating protein with death domain (FADD) interacts with Fas and initiates…”
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Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction by Kuwano, K, Nomoto, Y, Kunitake, R, Hagimoto, N, Matsuba, T, Nakanishi, Y, Hara, N

“…The history of patients with idiopathic pulmonary fibrosis (IPF) shows that the disease may be preceded by a viral-like illness. Although viruses have not been…”
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Apoptosis in the course of granulomatous inflammation in pulmonary sarcoidosis by Kunitake, R, Kuwano, K, Miyazaki, H, Hagimoto, N, Nomoto, Y, Hara, N

“…Sarcoidosis is a chronic inflammatory disease of unknown aetiology characterized by the formation of non‐necrotizing granulomas. The course of disease is…”
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B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary fibrosis and bronchiolitis obliterans-organizing pneumonia by Kaneko, Y, Kuwano, K, Kunitake, R, Kawasaki, M, Hagimoto, N, Hara, N

“…Interstitial lung diseases are thought to be associated with the infiltration of activated T‐lymphocytes. To induce an effective immune response,…”
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Analysis of Fas and Fas ligand expression and function in lung cancer cell lines by Kawasaki, M, Kuwano, K, Nakanishi, Y, Hagimoto, N, Takayama, K, Pei, X.-H, Maeyama, T, Yoshimi, M, Hara, N

“…The aim of this study was to investigate the expression of Fas and Fas ligand (FasL) and to determine the significance of these molecules in lung cancer cell…”
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Expression of p53, p21 (Waf1/Cip1/Sdi1) and Fas antigen in collagen vascular and granulomatous lung diseases by Kunitake, R, Kuwano, K, Miyazaki, H, Kawasaki, M, Hagimoto, N, Fujita, M, Kaneko, Y, Hara, N

“…Fas is expressed in various cells and transduces the cell death signal. p21 is a mediator of p53-dependent G1 arrest associated with deoxyribonucleic acid…”
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Apoptosis and Fas/Fas ligand mRNA expression in acute immune complex alveolitis in mice by Nomoto, Y, Kuwano, K, Hagimoto, N, Kunitake, R, Kawasaki, M, Hara, N

“…Deoxyribonucleic acid (DNA) strand breaks as a characteristic of apoptosis, and Fas antigen (Fas)/Fas ligand (FasL) expression may participate in acute immune…”
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B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary fibrosis and bronchiolitis obliterans-organizing pneumonia by Kaneko, Y., Kuwano, K., Kunitake, R., Kawasaki, M., Hagimoto, N., Hara, N.

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Anti-Vascular Endothelial Growth Factor Gene Therapy Attenuates Lung Injury and Fibrosis in Mice by Hamada, Naoki, Kuwano, Kazuyoshi, Yamada, Mizuho, Hagimoto, Naoki, Hiasa, Kenichi, Egashira, Kensuke, Nakashima, Nobutaka, Maeyama, Takashige, Yoshimi, Michihiro, Nakanishi, Yoichi

“…Vascular endothelial growth factor (VEGF) is an angiogenesis factor with proinflammatory roles. Flt-1 is one of the specific receptors for VEGF, and soluble…”
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TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells by Hagimoto, Naoki, Kuwano, Kazuyoshi, Inoshima, Ichiro, Yoshimi, Michihiro, Nakamura, Norio, Fujita, Masaki, Maeyama, Takashige, Hara, Nobuyuki

“…Transforming growth factor-beta 1 (TGF-beta 1) has important roles in lung fibrosis and the potential to induce apoptosis in several types of cells. We…”
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Multiple pulmonary nodules manifested in a patient with NK cell granular lymphocyte proliferative disorder by Furuno, T, Hara, N, Hagimoto, N, Mori, N, Muranishi, H

“…An 18-year-old man was admitted to our hospital with high temperature and dyspnea. A chest radiograph revealed the presence of multiple round nodules…”
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Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis by Kuwano, K, Hagimoto, N, Kawasaki, M, Yatomi, T, Nakamura, N, Nagata, S, Suda, T, Kunitake, R, Maeyama, T, Miyazaki, H, Hara, N

“…The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer…”
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