Search Results - "Haghnazari, Edwin"

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors by Navas, Tony A., Mohindru, Mani, Estes, Myka, Ma, Jing Ying, Sokol, Lubomir, Pahanish, Perry, Parmar, Simrit, Haghnazari, Edwin, Zhou, Li, Collins, Robert, Kerr, Irene, Nguyen, Aaron N., Xu, Yin, Platanias, Leonidas C., List, Alan A., Higgins, Linda S., Verma, Amit

“…The myelodysplastic syndromes (MDSs) are collections of heterogeneous hematologic diseases characterized by refractory cytopenias as a result of ineffective…”
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Phosphorylation of Rad55 on Serines 2, 8, and 14 Is Required for Efficient Homologous Recombination in the Recovery of Stalled Replication Forks by Herzberg, Kristina, Bashkirov, Vladimir I., Rolfsmeier, Michael, Haghnazari, Edwin, McDonald, W. Hayes, Anderson, Scott, Bashkirova, Elena V., Yates, John R., Heyer, Wolf-Dietrich

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Direct Kinase-to-Kinase Signaling Mediated by the FHA Phosphoprotein Recognition Domain of the Dun1 DNA Damage Checkpoint Kinase by Bashkirov, Vladimir I., Bashkirova, Elena V., Haghnazari, Edwin, Heyer, Wolf-Dietrich

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truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae by Janke, Ryan, Herzberg, Kristina, Rolfsmeier, Michael, Mar, Jordan, Bashkirov, Vladimir I, Haghnazari, Edwin, Cantin, Greg, Yates, John R. III, Heyer, Wolf-Dietrich

“…In Saccharomyces cerevisiae, the DNA damage response (DDR) is activated by the spatio-temporal colocalization of Mec1-Ddc2 kinase and the 9-1-1 clamp. In the…”
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The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide by Haghnazari, Edwin, Heyer, Wolf-Dietrich

“…The DNA damage checkpoint pathway and the MAP kinase pathway respond to various forms of environmental as well as endogenous stresses through signal…”
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Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation by Nguyen, Aaron N., Stebbins, Elizabeth G., Henson, Margaret, O'Young, Gilbert, Choi, Sun J., Quon, Diana, Damm, Debby, Reddy, Mamatha, Ma, Jing Y., Haghnazari, Edwin, Kapoun, Ann M., Medicherla, Satyanarayana, Protter, Andy, Schreiner, George F., Kurihara, Noriyoshi, Anderson, Judy, Roodman, G. David, Navas, Tony A., Higgins, Linda S.

“…The multiple myeloma (MM) bone marrow (BM) microenvironment plays a critical role in supporting tumor growth and survival as well as in promoting formation of…”
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Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment by Navas, Tony, Zhou, Li, Estes, Myka, Haghnazari, Edwin, Nguyen, Aaron N., Mo, Yongkai, Pahanish, Perry, Mohindru, Mani, Cao, Tim, Higgins, Linda S., Platanias, Leonidas C., List, Alan, Verma, Amit

“…Myelodysplastic syndromes (MDS) are common causes of ineffective hematopoiesis and cytopenias in the elderly. Various myelosuppressive and proinflammatory…”
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DNA damage-induced phosphorylation of Rad55 protein as a sentinel for DNA damage checkpoint activation in S. cerevisiae by Bashkirov, Vladimir I, Herzberg, Kristina, Haghnazari, Edwin, Vlasenko, Alexey S, Heyer, Wolf-Dietrich

“…Rad55 protein is one of two Rad51 paralogs in the budding yeast Saccharomyces cerevisiae and forms a stable heterodimer with Rad57, the other Rad51 paralog…”
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DNA damage checkpoint pathways exert multiple controls on the efficiency and outcome of the repair of a double-stranded DNA gap by Haghnazari, E, Heyer, W.D

“…A DNA gap repair assay was used to determine the effect of mutations in the DNA damage checkpoint system on the efficiency and outcome…”
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Inhibition of p38 MAPK by SCIO-469 Suppresses TNF Generation and Promotes CD34+ Cell Survival in an In Vitro MDS Cell Culture Model by Navas, Tony A., Nguyen, Aaron N., Ma, Jing Y., Stebbins, Elizabeth G., Haghnazari, Edwin, Heaton, Ruth, List, Alan F., Higgins, Linda S.

“…Progress in the development of more effective therapeutics for myelodysplastic syndrome (MDS) has been limited by the lack of targets critical to the…”
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Regulation of homologous recombinational DNA repair by DNA damage and replication block checkpoints in Saccharomyces cerevisiae by Haghnazari, Edwin

“…Chapter 2 focuses on the kinase-kinase signaling in the checkpoint cascade. We illustrate the role of Dun1's FHA domain in mediating the functional interaction…”
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SCIO-469, a Potent and Selective Inhibitor of p38a MAPK, Normalizes the Bone Marrow Microenvironment and Inhibits Multiple Myeloma Cell Proliferation in In Vitro and In Vivo Models by Nguyen, Aaron N., Reddy, Mamatha, Henson, Margaret, Stebbins, Elizabeth G., O'Young, Gilbert, Ma, Jing Y., Haghnazari, Edwin, Kapoun, Ann M., Medicherla, Satya, Protter, Andy, Navas, Tony A., Higgins, Linda S.

“…Despite recent advances in the treatment of multiple myeloma (MM), this disease remains incurable. Accumulating evidence suggest that the bone marrow (BM)…”
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Inhibition of p38alpha MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment by Navas, Tony, Zhou, Li, Estes, Myka, Haghnazari, Edwin, Nguyen, Aaron N, Mo, Yongkai, Pahanish, Perry, Mohindru, Mani, Cao, Tim, Higgins, Linda S, Platanias, Leonidas C, List, Alan, Verma, Amit, Bhagat, T, Gajavelli, S, Kambhampati, S

“…Myelodysplastic syndromes (MDS) are common causes of ineffective hematopoiesis and cytopenias in the elderly. Various myelosuppressive and proinflammatory…”
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Construction of a human Semaphorin 5 expression plasmid by Haghnazari, Edwin

“…Chromosomal region 3p21.3 is deleted in nearly 100% of small cell lung cancer (SCLC) cells examined, suggesting the presence of one or more tumor suppressor…”
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