Search Results - "Hagge, Deanna"

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans by Tobin, David M., Vary, Jay C., Ray, John P., Walsh, Gregory S., Dunstan, Sarah J., Bang, Nguyen D., Hagge, Deanna A., Khadge, Saraswoti, King, Mary-Claire, Hawn, Thomas R., Moens, Cecilia B., Ramakrishnan, Lalita

“…Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from…”
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Post-exposure prophylaxis (PEP) efficacy of rifampin, rifapentine, moxifloxacin, minocycline, and clarithromycin in a susceptible-subclinical model of leprosy by Lenz, Shannon M, Collins, Jaymes H, Ray, Nashone A, Hagge, Deanna A, Lahiri, Ramanuj, Adams, Linda B

“…Subclinical infection with Mycobacterium leprae is one potential source of leprosy transmission, and post-exposure prophylaxis (PEP) regimens have been…”
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A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood by Zhou, Angela X, Scriba, Thomas J, Day, Cheryl L, Hagge, Deanna A, Seshadri, Chetan

“…T cell receptors (TCRs) encode the history of antigenic challenge within an individual and have the potential to serve as molecular markers of infection. In…”
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ENLIST 1: An International Multi-centre Cross-sectional Study of the Clinical Features of Erythema Nodosum Leprosum by Walker, Stephen L, Balagon, Marivic, Darlong, Joydeepa, Doni, Shimelis N, Hagge, Deanna A, Halwai, Vikas, John, Annamma, Lambert, Saba M, Maghanoy, Armi, Nery, Jose A C, Neupane, Kapil D, Nicholls, Peter G, Pai, Vivek V, Parajuli, Pawan, Sales, Anna M, Sarno, Euzenir, Shah, Mahesh, Tsegaye, Digafe, Lockwood, Diana N J

“…Erythema nodosum leprosum (ENL) is a severe multisystem immune mediated complication of borderline lepromatous leprosy and lepromatous leprosy. ENL is…”
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Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy by Toh, Han-Siong, Maharjan, Jeni, Thapa, Ruby, Neupane, Kapil Dev, Shah, Mahesh, Baral, Suwash, Hagge, Deanna A, Napit, Indra Bahadur, Lockwood, Diana N J

“…Neuropathic pain (NP) can occur as a chronic complication of leprosy neuropathy. NP epidemiology and its impact on patients have not been well documented. This…”
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Common Polymorphisms in the NOD2 Gene Region Are Associated with Leprosy and Its Reactive States by Berrington, William Richard, Macdonald, Murdo, Khadge, Saraswoti, Sapkota, Bishwa Raj, Janer, Marta, Hagge, Deanna Alisa, Kaplan, Gilla, Hawn, Thomas Richard

“…Background. Because of its wide spectrum of clinical manifestations and its well-defined immunological complications, leprosy is a useful disease for studying…”
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T-cell regulation in lepromatous leprosy by Bobosha, Kidist, Wilson, Louis, van Meijgaarden, Krista E, Bekele, Yonas, Zewdie, Martha, van der Ploeg-van Schip, Jolien J, Abebe, Markos, Hussein, Jemal, Khadge, Saraswoti, Neupane, Kapil D, Hagge, Deanna A, Jordanova, Ekaterina S, Aseffa, Abraham, Ottenhoff, Tom H M, Geluk, Annemieke

“…Regulatory T (Treg) cells are known for their role in maintaining self-tolerance and balancing immune reactions in autoimmune diseases and chronic infections…”
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Money matters: Priorities in leprosy research funding by Scollard, David, Trienekens, Suzan C.M, Tucker, Andie, Goswami, Subhojit, Hagge, Deanna A

“…Priorities for leprosy research are discussed frequently, but the variety of sources of research funding, and the choices of research priorities by funding…”
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An assessment of the reported impact of the COVID-19 pandemic on leprosy services using an online survey of practitioners in leprosy referral centres by de Barros, Barbara, Lambert, Saba M, Negera, Edessa, de Arquer, Guillermo Robert, Sales, Anna M, Darlong, Joydeepa, Dias, Vivianne L A, Rozario, Benjamin Jewel, Pai, Vivek V, Alinda, Medhi Denisa, Listiawan, M Yulianto, Hagge, Deanna A, Shah, Mahesh, Lockwood, Diana N J, Walker, Stephen L

“…Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to governments implementing a variety of public health measures to control…”
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Evaluation of a self-help intervention to promote the health and wellbeing of marginalised people including those living with leprosy in Nepal: a prospective, observational, cluster-based, cohort study with controls by Shrestha, Dilip, Napit, Indra B, Ansari, Subi, Choudhury, Sopna Mannan, Dhungana, Bishnu, Gill, Paramjit, Griffiths, Frances, Gwyther, Holly, Hagge, Deanna, Kandel, Shovakhar, Puri, Suraj, Sartori, Jo, Watson, Samuel Ian, Lilford, Richard

“…People affected by leprosy are at increased risk of ulcers from peripheral nerve damage. This in turn can lead to visible impairments, stigmatisation and…”
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An individual randomised efficacy trial of autologous blood products, leukocyte and platelet-rich fibrin (L-PRF), to promote ulcer healing in leprosy in Nepal: the TABLE trial protocol by Napit, Indra B, Shrestha, Dilip, Bishop, Jon, Choudhury, Sopna, Dulal, Santosh, Gill, Paramjit, Gkini, Eleni, Gwyther, Holly, Hagge, Deanna A, Neupane, Karuna, Sartori, Jo, Slinn, Gemma, Watson, Samuel I, Lilford, Richard

“…Leprosy is curable with multidrug therapy and treatment in the early stages can prevent disability. However, local nerve damage can lead to injury and…”
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Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction by Teles, Rosane M B, Lu, Jing, Tió-Coma, Maria, Goulart, Isabela M B, Banu, Sayera, Hagge, Deanna, Bobosha, Kidist, Ottenhoff, Tom H M, Pellegrini, Matteo, Geluk, Annemieke, Modlin, Robert L

“…Reversal reactions (RRs) in leprosy are characterized by a reduction in the number of bacilli in lesions associated with an increase in cell-mediated immunity…”
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Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study by Tió-Coma, Maria, van Hooij, Anouk, Bobosha, Kidist, van der Ploeg-van Schip, Jolien J., Banu, Sayera, Khadge, Saraswoti, Thapa, Pratibha, Kunwar, Chhatra B., Goulart, Isabela M., Bekele, Yonas, Hagge, Deanna A., Moraes, Milton O., Teles, Rosane M. B., Pinheiro, Roberta Olmo, van Zwet, Erik W., Goeman, Jelle J., Aseffa, Abraham, Haks, Mariëlle C., Ottenhoff, Tom H. M., Modlin, Robert L., Geluk, Annemieke

“…Early diagnosis of leprosy is challenging, particularly its inflammatory reactions, the major cause of irreversible neuropathy in leprosy. Current diagnostics…”
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The Many Hosts of Mycobacteria 9 (MHM9): A conference report by Klever, Abigail Marie, Alexander, Kathleen A., Almeida, Deepak, Anderson, Matthew Z., Ball, Ray L., Beamer, Gillian, Boggiatto, Paola, Buikstra, Jane E., Chandler, Bruce, Claeys, Tiffany A., Concha, Aislinn E., Converse, Paul J., Derbyshire, Keith M., Dobos, Karen M., Dupnik, Kathryn M., Endsley, Janice J., Endsley, Mark A., Fennelly, Kevin, Franco-Paredes, Carlos, Hagge, Deanna A., Hall-Stoodley, Luanne, Hayes, Don, Hirschfeld, Katherine, Hofman, Courtney A., Honda, Jennifer R., Hull, Natalie M., Kramnik, Igor, Lacourciere, Karen, Lahiri, Ramanuj, Lamont, Elise A., Larsen, Michelle H., Lemaire, Timothy, Lesellier, Sandrine, Lee, Naomi R., Lowry, Christopher A., Mahfooz, Najmus S., McMichael, Temet M., Merling, Marlena R., Miller, Michele A., Nagajyothi, Jyothi F., Nelson, Elizabeth, Nuermberger, Eric L., Pena, Maria T., Perea, Claudia, Podell, Brendan K., Pyle, Charlie J., Quinn, Fred D., Rajaram, Murugesan V.S., Mejia, Oscar Rosas, Rothoff, Michelle, Sago, Saydie A., Salvador, Liliana C.M., Simonson, Andrew W., Spencer, John S., Sreevatsan, Srinand, Subbian, Selvakumar, Sunstrum, James, Tobin, David M., Vijayan, K.K.Vidya, Wright, Caelan T.O., Robinson, Richard T.

“…The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and…”
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Methotrexate and prednisolone study in erythema nodosum leprosum (MaPs in ENL) protocol: a double-blind randomised clinical trial by de Barros, Barbara, Lambert, Saba M, Shah, Mahesh, Pai, Vivek V, Darlong, Joydeepa, Rozario, Benjamin Jewel, Alinda, Medhi Denisa, Sales, Anna M, Doni, Shimelis, Hagge, Deanna A, Shrestha, Dilip, Listiawan, M. Yulianto, Yitaye, Abeba M, Nery, Jose A C, Neupane, Kapil D, Dias, Vivianne L A, Butlin, C. Ruth, Nicholls, Peter G, Lockwood, Diana, Walker, Stephen L

“…IntroductionErythema nodosum leprosum (ENL) is an immunological complication of leprosy. ENL results in morbidity and disability and if it is not treated can…”
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Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial by Wagenaar, Inge, Post, Erik, Brandsma, Wim, Bowers, Bob, Alam, Khorshed, Shetty, Vanaja, Pai, Vivek, Husain, Sajid, Sigit Prakoeswa, Cita Rosita, Astari, Linda, Hagge, Deanna, Shah, Mahesh, Neupane, Kapil, Tamang, Krishna Bahadur, Nicholls, Peter, Richardus, Jan Hendrik

“…While prednisolone is commonly used to treat recent nerve function impairment (NFI) in leprosy patients, the optimal treatment duration has not yet been…”
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Persistent dengue emergence: the 7 years surrounding the 2010 epidemic in Nepal by Pandey, Basu Dev, Pandey, Kishor, Neupane, Biswas, Shah, Yogendra, Adhikary, Krishna P., Gautam, Ishan, Hagge, Deanna A., Morita, Kouichi

“…Background Dengue fever (DF) is an emerging public health problem in Nepal, and yet neither the magnitude of the DF burden or its epidemiological trends are…”
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IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy by Hagge, Deanna A, Scollard, David M, Ray, Nashone A, Marks, Vilma T, Deming, Angelina T, Spencer, John S, Adams, Linda B

“…Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the…”
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Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist by Shah, Javeed A., Berrington, William R., Vary, James C., Wells, Richard D., Peterson, Glenna J., Kunwar, Chhatra B., Khadge, Saraswoti, Hagge, Deanna A., Hawn, Thomas R.

“…Leprosy is a chronic disease characterized by skin and peripheral nerve pathology and immune responses that fail to control Mycobacterium leprae…”
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Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions by Cogen, Anna L, Walker, Stephen L, Roberts, Chrissy H, Hagge, Deanna A, Neupane, Kapil D, Khadge, Saraswoti, Lockwood, Diana N J

“…Leprosy, a chronic granulomatous disease affecting the skin and nerves, is caused by Mycobacterium leprae (M. leprae). The type of leprosy developed depends…”
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