Search Results - "Hagg, Sara"

Sex differences in biological aging with a focus on human studies by Hagg, S, Jylhava, J

“…Aging is a complex biological process characterized by hallmark features accumulating over the life course, shaping the individual's aging trajectory and…”
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Biological Age Predictors by Jylhävä, Juulia, Pedersen, Nancy L., Hägg, Sara

“…The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely…”
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Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up by Li, Xia, Ploner, Alexander, Wang, Yunzhang, Magnusson, Patrik Ke, Reynolds, Chandra, Finkel, Deborah, Pedersen, Nancy L, Jylhävä, Juulia, Hägg, Sara

“…Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological age (CA)…”
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Telomere Length and All-Cause Mortality: A Meta-analysis by Wang, Qi, Zhan, Yiqiang, Pedersen, Nancy L, Fang, Fang, Hägg, Sara

“…Telomere attrition is associated with increased morbidity and mortality of various age-related diseases. Reports of association between telomere length (TL)…”
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Telomere Length Dynamics and Atherosclerotic Disease by Hagg, S

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Frailty and comorbidity in predicting community COVID‐19 mortality in the U.K. Biobank: The effect of sampling by Mak, Jonathan K. L., Kuja‐Halkola, Ralf, Wang, Yunzhang, Hägg, Sara, Jylhävä, Juulia

“…Background/Objectives Frailty has been linked to increased risk of COVID‐19 mortality, but evidence is mainly limited to hospitalized older individuals. This…”
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Telomere length and cardiovascular disease risk by Zhan, Yiqiang, Hägg, Sara

“…PURPOSE OF REVIEWTelomere length has been hypothesized as a putative biomarker for cardiovascular disease. However, the findings are mixed and shared…”
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A Frailty Index for UK Biobank Participants by Williams, Dylan M, Jylhävä, Juulia, Pedersen, Nancy L, Hägg, Sara

“…Abstract Background Frailty indices (FIs) measure variation in health between aging individuals. Researching FIs in resources with large-scale genetic and…”
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Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden by Kananen, Laura, Hong, Xu, Annetorp, Martin, Mak, Jonathan K L, Jylhävä, Juulia, Eriksdotter, Maria, Hägg, Sara, Religa, Dorota

“…To analyse if the health progression of geriatric Covid-19 survivors three months after an acute Covid-19 infection was worse than in other geriatric patients…”
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A genome‐wide association study of the frailty index highlights brain pathways in ageing by Atkins, Janice L., Jylhävä, Juulia, Pedersen, Nancy L., Magnusson, Patrik K., Lu, Yi, Wang, Yunzhang, Hägg, Sara, Melzer, David, Williams, Dylan M., Pilling, Luke C.

“…Frailty is a common geriatric syndrome and strongly associated with disability, mortality and hospitalization. Frailty is commonly measured using the frailty…”
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Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance by Hägg, Sara, Jylhävä, Juulia, Wang, Yunzhang, Czene, Kamila, Grassmann, Felix

“…Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most aging-related diseases as well as immunological processes. However,…”
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Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk: A Mendelian Randomization Study by Tang, Bowen, Wang, Yunzhang, Jiang, Xia, Thambisetty, Madhav, Ferrucci, Luigi, Johnell, Kristina, Hägg, Sara

“…Previous studies have highlighted antidiabetic drugs as repurposing candidates for Alzheimer disease (AD), but the disease-modifying effects are still unclear…”
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Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care by Hägg, Sara, Jylhävä, Juulia, Wang, Yunzhang, Xu, Hong, Metzner, Carina, Annetorp, Martin, Garcia-Ptacek, Sara, Khedri, Masih, Boström, Anne-Marie, Kadir, Ahmadul, Johansson, Anna, Kivipelto, Miia, Eriksdotter, Maria, Cederholm, Tommy, Religa, Dorota

“…To analyze whether frailty and comorbidities are associated with in-hospital mortality and discharge to home in older adults hospitalized for coronavirus…”
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COVID vaccination in older adults by Hägg, Sara, Religa, Dorota

“…Vaccine immunity against SARS-CoV-2 wanes over time and is generally lower in the older population. Recent studies show that booster doses may increase…”
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Telomere Length Shortening in Alzheimer's Disease: Procedures for a Causal Investigation Using Single Nucleotide Polymorphisms in a Mendelian Randomization Study by Zhan, Yiqiang, Hägg, Sara

“…Measuring the length of telomeres, repetitive nucleotide sequences capping the chromosomes which shortens by each cell division, has become a popular way of…”
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Reciprocal interaction between depression and pain: results from a comprehensive bidirectional Mendelian randomization study and functional annotation analysis by Tang, Bowen, Meng, Weihua, Hägg, Sara, Burgess, Stephen, Jiang, Xia

“…To understand a putative causal link for depression and pain, we retrieved summary statistics from genome-wide association studies conducted for pain at 7…”
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Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank by Lehto, Kelli, Hägg, Sara, Lu, Donghao, Karlsson, Robert, Pedersen, Nancy L., Mosing, Miriam A.

“…Being adopted early in life, an indicator of exposure to early-life adversity, has been consistently associated with poor mental health outcomes in adulthood…”
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Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study by Williams, Dylan M, Hägg, Sara, Pedersen, Nancy L

“…Higher circulating antioxidant concentrations are associated with a lower risk of late-onset Alzheimer disease (AD) in observational studies, suggesting that…”
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Genetic heterogeneity and subtypes of major depression by Nguyen, Thuy-Dung, Harder, Arvid, Xiong, Ying, Kowalec, Kaarina, Hägg, Sara, Cai, Na, Kuja-Halkola, Ralf, Dalman, Christina, Sullivan, Patrick F., Lu, Yi

“…Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic factors distinguish MD patient subgroups (genetic heterogeneity)…”
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Should we invest in biological age predictors to treat colorectal cancer in older adults? by Hagg, S, Jylhava, J

“…Colorectal cancer (CRC) is a chronic disease of the old population with slow development progressing into clinical signs and symptoms. Biological aging is…”
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