Search Results - "Hagey, Lee R."

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades by Hofmann, Alan F., Hagey, Lee R.

“…During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of…”
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Bile salts of vertebrates: structural variation and possible evolutionary significance[S] by Hofmann, Alan F., Hagey, Lee R., Krasowski, Matthew D.

“…Biliary bile salt composition of 677 vertebrate species (103 fish, 130 reptiles, 271 birds, 173 mammals) was determined. Bile salts were of three types: C27…”
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Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis by Tabibian, James H., O'Hara, Steven P., Trussoni, Christy E., Tietz, Pamela S., Splinter, Patrick L., Mounajjed, Taofic, Hagey, Lee R., LaRusso, Nicholas F.

“…Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be…”
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MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism by de Aguiar Vallim, Thomas Q., Tarling, Elizabeth J., Ahn, Hannah, Hagey, Lee R., Romanoski, Casey E., Lee, Richard G., Graham, Mark J., Motohashi, Hozumi, Yamamoto, Masayuki, Edwards, Peter A.

“…Specific bile acids are potent signaling molecules that modulate metabolic pathways affecting lipid, glucose and bile acid homeostasis, and the microbiota…”
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A “Forward Genomics” Approach Links Genotype to Phenotype using Independent Phenotypic Losses among Related Species by Hiller, Michael, Schaar, Bruce T., Indjeian, Vahan B., Kingsley, David M., Hagey, Lee R., Bejerano, Gill

“…Genotype-phenotype mapping is hampered by countless genomic changes between species. We introduce a computational “forward genomics” strategy that—given only…”
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Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR by Krasowski, Matthew D., Ni, Ai, Hagey, Lee R., Ekins, Sean

“…Nuclear hormone receptors (NHRs) are transcription factors that work in concert with co-activators and co-repressors to regulate gene expression. Some examples…”
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Diversity of Bile Salts in Fish and Amphibians: Evolution of a Complex Biochemical Pathway by Hagey, Lee R., Møller, Peter R., Hofmann, Alan F., Krasowski, Matthew D.

“…Bile salts are the major end metabolites of cholesterol and are also important in lipid and protein digestion, as well as shaping of the gut microflora…”
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The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice by Kuo, Shiu-Ming, Merhige, Patricia M, Hagey, Lee R

“…Previous studies have suggested roles of probiotics and prebiotics on body weight management and intestinal function. Here, the effects of a dietary prebiotic,…”
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Human cecal bile acids: concentration and spectrum by Hamilton, James P, Xie, Guofeng, Raufman, Jean-Pierre, Hogan, Susan, Griffin, Terrance L, Packard, Christine A, Chatfield, Dale A, Hagey, Lee R, Steinbach, Joseph H, Hofmann, Alan F

“…To obtain information on the concentration and spectrum of bile acids in human cecal content, samples were obtained from 19 persons who had died an unnatural…”
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Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine by Weerachayaphorn, Jittima, Mennone, Albert, Soroka, Carol J, Harry, Kathy, Hagey, Lee R, Kensler, Thomas W, Boyer, James L

“…The transcription factor nuclear factor-E2-related factor 2 (Nrf2) is a key regulator for induction of hepatic detoxification and antioxidant mechanisms, as…”
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Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury by Li, Man, Mennone, Albert, Soroka, Carol J., Hagey, Lee R., Ouyang, Xinshou, Weinman, Edward J., Boyer, James L.

“…The intercellular adhesion molecule 1 (ICAM‐1) is induced in mouse liver after bile duct ligation (BDL) and plays a key role in neutrophil‐mediated liver…”
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Evolution of pharmacologic specificity in the pregnane X receptor by Ekins, Sean, Reschly, Erica J, Hagey, Lee R, Krasowski, Matthew D

“…The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study,…”
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Evolution of the bile salt nuclear receptor FXR in vertebrates by Reschly, Erica J, Ai, Ni, Ekins, Sean, Welsh, William J, Hagey, Lee R, Hofmann, Alan F, Krasowski, Matthew D

“…Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding…”
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Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites by Hagey, Lee R, Vidal, Nicolas, Hofmann, Alan F, Krasowski, Matthew D

“…Bile salts are the major end-metabolites of cholesterol and are also important in lipid and protein digestion and in influencing the intestinal microflora. We…”
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Functional evolution of the vitamin D and pregnane X receptors by Reschly, Erica J, Bainy, Afonso Celso Dias, Mattos, Jaco Joaquim, Hagey, Lee R, Bahary, Nathan, Mada, Sripal R, Ou, Junhai, Venkataramanan, Raman, Krasowski, Matthew D

“…The vitamin D receptor (VDR) and pregnane X receptor (PXR) are nuclear hormone receptors of the NR1I subfamily that show contrasting patterns of cross-species…”
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Improved Chemical Synthesis, X-Ray Crystallographic Analysis, and NMR Characterization of (22R)-/(22S)-Hydroxy Epimers of Bile Acids by Omura, Kaoru, Ohsaki, Ayumi, Zhou, Biao, Kushida, Manaka, Mitsuma, Takashi, Kobayashi, Akiko, Hagey, Lee R., Hofmann, Alan F., Iida, Takashi

“…We report an improved synthesis of the (22 R )- and (22 S )-epimers of 3α,7α,12α,22-tetrahydroxy-5β-cholan-24-oic acid and 3α,7α,22-trihydroxy-5β-cholan-24-oic…”
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Altered lipid metabolism in gastroschisis: A novel hypothesis by Jones, Kenneth Lyons, Weiss, Lauren A., Hagey, Lee R., Gonzalez, Vanessa, Benirschke, Kurt, Chambers, Christina D.

“…Gastroschisis is a congenital abdominal wall defect where there is herniation of abdominal organs. Optimal maternal nutritional intake, in particular, fatty…”
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Ligand specificity and evolution of liver X receptors by Reschly, Erica J., Ai, Ni, Welsh, William J., Ekins, Sean, Hagey, Lee R., Krasowski, Matthew D.

“…Liver X receptors (LXRs) are key regulators of lipid and cholesterol metabolism in mammals. Little is known, however, about the function and evolution of LXRs…”
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Evolution of the Pregnane X Receptor: Adaptation to Cross-Species Differences in Biliary Bile Salts by Krasowski, Matthew D, Yasuda, Kazuto, Hagey, Lee R, Schuetz, Erin G

“…The pregnane X receptor (PXR) regulates the metabolism and elimination of bile salts, steroids, and xenobiotics. The sequence of the PXR ligand-binding domain…”
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The changing metabolic landscape of bile acids – keys to metabolism and immune regulation by Mohanty, Ipsita, Allaband, Celeste, Mannochio-Russo, Helena, El Abiead, Yasin, Hagey, Lee R., Knight, Rob, Dorrestein, Pieter C.

“…Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community composition and mediate inflammation,…”
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