Search Results - "Hagenaars, Sophie C."

Standardization of the tumor-stroma ratio scoring method for breast cancer research by Hagenaars, Sophie C., Vangangelt, Kiki M. H., Van Pelt, Gabi W., Karancsi, Zsófia, Tollenaar, Rob A. E. M., Green, Andrew R., Rakha, Emad A., Kulka, Janina, Mesker, Wilma E.

“…Purpose The tumor-stroma ratio (TSR) has repeatedly proven to be correlated with patient outcomes in breast cancer using large retrospective cohorts. However,…”
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RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis by Huang, Yongsheng, Liu, Sijia, Shan, Mengjie, Hagenaars, Sophie C., Mesker, Wilma E., Cohen, Danielle, Wang, Lin, Zheng, Zhi, Devilee, Peter, Tollenaar, Rob A. E. M., Li, Zhangfu, Song, Yongmei, Zhang, Long, Li, Dan, ten Dijke, Peter

“…Transforming growth factor-β (TGF-β) acts as a pro-metastatic factor in advanced breast cancer. RNF12, an E3 ubiquitin ligase, stimulates TGF-β signaling by…”
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LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation by Fan, Chuannan, Wang, Qian, Kuipers, Thomas B, Cats, Davy, Iyengar, Prasanna Vasudevan, Hagenaars, Sophie C, Mesker, Wilma E, Devilee, Peter, Tollenaar, Rob A E M, Mei, Hailiang, ten Dijke, Peter

“…Epithelial cells acquire mesenchymal phenotypes through epithelial‐mesenchymal transition (EMT) during cancer progression. However, how epithelial cells retain…”
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Tumour-stroma ratio (TSR) in breast cancer: comparison of scoring core biopsies versus resection specimens by Karancsi, Zsófia, Hagenaars, Sophie C., Németh, Kristóf, Mesker, Wilma E., Tőkés, Anna Mária, Kulka, Janina

“…Purpose Tumour-stroma ratio (TSR) is an important prognostic and predictive factor in several tumour types. The aim of this study is to determine whether TSR…”
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Tumor‐stroma ratio is associated with Miller‐Payne score and pathological response to neoadjuvant chemotherapy in HER2‐negative early breast cancer by Hagenaars, Sophie C., Groot, Stefanie, Cohen, Danielle, Dekker, Tim J. A., Charehbili, Ayoub, Meershoek‐Klein Kranenbarg, Elma, Duijm‐de Carpentier, Marjolijn, Pijl, Hanno, Putter, Hein, Tollenaar, Rob A. E. M., Kroep, Judith R., Mesker, Wilma E.

“…The tumor‐stroma ratio (TSR) has proven to be a strong prognostic factor in breast cancer, demonstrating better survival for patients with stroma‐low tumors…”
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Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer by Liu, Sijia, Dinther, Maarten, Hagenaars, Sophie C., Gu, Yuanzhuo, Kuipers, Thomas B., Mei, Hailiang, Gomez‐Puerto, Maria Catalina, Mesker, Wilma E., Dijke, Peter

“…Triple‐negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat due to its aggressive characteristics and low response to the…”
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Characteristics of tumour stroma in regional lymph node metastases in colorectal cancer patients: a theoretical framework for future diagnostic imaging with FAPI PET/CT by Polack, Meaghan, Hagenaars, Sophie C., Couwenberg, Alice, Kool, Walter, Tollenaar, Rob A. E. M., Vogel, Wouter V., Snaebjornsson, Petur, Mesker, Wilma E.

“…Purpose The recently developed fibroblast activation protein inhibitor (FAPI) tracer for PET/CT, binding tumour-stromal cancer-associated fibroblasts, is a…”
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Lessons Learned from Setting Up a Prospective, Longitudinal, Multicenter Study with Women at High Risk for Breast Cancer by Patuleia, Susana I S, Hagenaars, Sophie C, Moelans, Cathy B, Ausems, Margreet G E M, van Gils, Carla H, Tollenaar, Rob A E M, van Diest, Paul J, Mesker, Wilma E, van der Wall, Elsken

“…Women identified with an increased risk of breast cancer due to mutations in cancer susceptibility genes or a familial history of breast cancer undergo…”
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Longitudinal Serum Protein Analysis of Women with a High Risk of Developing Breast Cancer Reveals Large Interpatient Versus Small Intrapatient Variations: First Results from the TESTBREAST Study by Hagenaars, Sophie, Dekker, Lennard, Ravesteijn, Bob, van Vlierberghe, Ronald, Romijn, Fred, Verhoeff, Linda, Witkamp, Arjen, Schenk, Karin, Keymeulen, Kristien, Menke-Pluijmers, Marian, Dassen, Anneriet, Kortmann, Birgitta, de Vries, Jakob, Rutgers, Emiel, van der Burgt, Yuri, Meershoek-Klein Kranenbarg, Elma, Cobbaert, Christa, Luider, Theo, Mesker, Wilma, Tollenaar, Rob

“…The prospective, multicenter TESTBREAST study was initiated with the aim of identifying a novel panel of blood-based protein biomarkers to enable early breast…”
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