Search Results - "Hagedorn, Peter"

Managing the sequence-specificity of antisense oligonucleotides in drug discovery by Hagedorn, Peter H, Hansen, Bo R, Koch, Troels, Lindow, Morten

“…All drugs perturb the expression of many genes in the cells that are exposed to them. These gene expression changes can be divided into effects resulting from…”
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Long Noncoding RNA Expression during Human B-Cell Development by Petri, Andreas, Dybkær, Karen, Bøgsted, Martin, Thrue, Charlotte Albæk, Hagedorn, Peter H, Schmitz, Alexander, Bødker, Julie Støve, Johnsen, Hans Erik, Kauppinen, Sakari

“…Long noncoding RNAs (lncRNAs) have emerged as important regulators of diverse cellular processes, but their roles in the developing immune system are poorly…”
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Locked nucleic acid: modality, diversity, and drug discovery by Hagedorn, Peter H., Persson, Robert, Funder, Erik D., Albæk, Nanna, Diemer, Sanna L., Hansen, Dennis J., Møller, Marianne R., Papargyri, Natalia, Christiansen, Helle, Hansen, Bo R., Hansen, Henrik F., Jensen, Mads A., Koch, Troels

“…•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and modulate RNA.•The high binding affinity of LNAs significantly improves…”
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Static equilibrium configuration and nonlinear dynamics of slightly curved cantilevered pipe conveying fluid by Zhou, K., Ni, Q., Chen, W., Dai, H.L., Hagedorn, Peter, Wang, L.

“…In engineering applications, fluid-conveying pipes usually have geometric imperfections or initially curved configurations. Unlike the initially curved pipe…”
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RNase H sequence preferences influence antisense oligonucleotide efficiency by Kielpinski, Lukasz J, Hagedorn, Peter H, Lindow, Morten, Vinther, Jeppe

“…RNase H cleaves RNA in RNA-DNA duplexes. It is present in all domains of life as well as in multiple viruses and is essential for mammalian development and for…”
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Identifying Suitable Target Regions and Analyzing Off-Target Effects of Therapeutic Oligonucleotides by Pedersen, Lykke, Hagedorn, Peter H, Koch, Troels

“…Antisense oligonucleotides (AONs) that promote degradation of complementary RNA are being developed as therapeutics. Here, we describe a simple computational…”
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Validation of a software-based torsional measurement method of the lower limb: A retrospective study by Leonard, Grünwald, Shuntaro, Nejima, Tina, Histing, Steffen, Schröter, Peter, Hagedorn

“…The aim of this study was to evaluate a software-based measurement tool of computed tomography imaging to assess torsional alignment of the lower limb-usually…”
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STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma by Kopp, Katharina, Ralfkiaer, Ulrik, Mette Gjerdrum, Lise, Helvad, Rikke, Pedersen, Ida, Litman, Thomas, Jønson, Lars, Hagedorn, Peter, Krejsgaard, Thorbjørn, Gniadecki, Robert, Bonefeld, Charlotte, Skov, Lone, Geisler, Carsten, Wasik, Mariusz A., Ralfkiaer, Elisabeth, Ødum, Niels, Woetmann, Anders

“…The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains elusive. Recent discoveries indicate that the oncogenic microRNA miR-155 is overexpressed in…”
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Transcriptional regulation by an NAC (NAM-ATAF1,2-CUC2) transcription factor attenuates ABA signalling for efficient basal defence towards Blumeria graminis f. sp. hordei in Arabidopsis by Jensen, Michael K, Hagedorn, Peter H, de Torres-Zabala, Marta, Grant, Murray R, Rung, Jesper H, Collinge, David B, Lyngkjaer, Michael F

“…ATAF1 is a member of a largely uncharacterized plant-specific gene family encoding NAC transcription factors, and is induced in response to various abiotic and…”
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Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines by Hansen, Jakob Bondo, Tonnesen, Morten Fog, Madsen, Andreas Nygaard, Hagedorn, Peter H., Friberg, Josefine, Grunnet, Lars Groth, Heller, R. Scott, Nielsen, Anja Østergren, Størling, Joachim, Baeyens, Luc, Anker-Kitai, Leeat, Qvortrup, Klaus, Bouwens, Luc, Efrat, Shimon, Aalund, Mogens, Andrews, Nancy C., Billestrup, Nils, Karlsen, Allan E., Holst, Birgitte, Pociot, Flemming, Mandrup-Poulsen, Thomas

“…Reactive oxygen species (ROS) contribute to target-cell damage in inflammatory and iron-overload diseases. Little is known about iron transport regulation…”
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A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides by Dieckmann, Andreas, Hagedorn, Peter H., Burki, Yvonne, Brügmann, Christine, Berrera, Marco, Ebeling, Martin, Singer, Thomas, Schuler, Franz

“…The successful development of high-affinity gapmer antisense oligonucleotide (ASO) therapeutics containing locked nucleic acid (LNA) or constrained ethyl (cEt)…”
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RNase H sequence preferences influence antisense oligonucleotide efficiency by Kiełpiński, Łukasz J, Hagedorn, Peter H, Lindow, Morten, Vinther, Jeppe

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Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties by Papargyri, Natalia, Pontoppidan, Malene, Andersen, Mikael R., Koch, Troels, Hagedorn, Peter H.

“…The identification of molecules that can modulate RNA or protein function and the subsequent chemical and structural optimization to refine such molecules into…”
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Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers by Kiełpiński, Łukasz J, Funder, Erik Daa, Schmidt, Steffen, Hagedorn, Peter H

“…Phosphorothioate (PS) modification of antisense oligonucleotides (ASOs) is a critical factor enabling their therapeutic use. Standard chemical synthesis…”
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Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features by Hagedorn, Peter H, Brown, Jeffrey M, Easton, Amy, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E, Mercer, Stephen E, Li, Dong, Loy, James, Høg, Anja M, Jensen, Marianne L, Gill, Martin, Cacace, Angela M

“…Antisense oligonucleotides are a relatively new therapeutic modality and safety evaluation is still a developing area of research. We have observed that some…”
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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice by Hagedorn, Peter H, Pontoppidan, Malene, Bisgaard, Tina S, Berrera, Marco, Dieckmann, Andreas, Ebeling, Martin, Møller, Marianne R, Hudlebusch, Heidi, Jensen, Marianne L, Hansen, Henrik F, Koch, Troels, Lindow, Morten

“…Abstract Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as…”
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Anatomical work-up of an individual with multiple muscular variants on both forearms by Hagedorn, Peter S., Hirt, Bernhard, Shiozawa, Thomas, Neckel, Peter H.

“…Muscular variants of the forearm are common and frequently cause neurovascular compression syndromes, especially when interfering with the compact topography…”
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Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL) by Ralfkiaer, Ulrik, Hagedorn, Peter H., Bangsgaard, Nannie, Løvendorf, Marianne B., Ahler, Charlotte B., Svensson, Lars, Kopp, Katharina L., Vennegaard, Marie T., Lauenborg, Britt, Zibert, John R., Krejsgaard, Thorbjørn, Bonefeld, Charlotte M., Søkilde, Rolf, Gjerdrum, Lise M., Labuda, Tord, Mathiesen, Anne-Merete, Grønbæk, Kirsten, Wasik, Mariusz A., Sokolowska-Wojdylo, Malgorzata, Queille-Roussel, Catherine, Gniadecki, Robert, Ralfkiaer, Elisabeth, Geisler, Carsten, Litman, Thomas, Woetmann, Anders, Glue, Christian, Røpke, Mads A., Skov, Lone, Odum, Niels

“…Cutaneous T-cell lymphomas (CTCLs) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult because of a…”
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A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent by Pedersen, Lykke, Hagedorn, Peter H, Lindholm, Marie Wickström, Lindow, Morten

“…Antisense oligonucleotides complementary to RNA targets promise generality and ease of drug design. The first systemically administered antisense drug was…”
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A cross-sectional screening by next-generation sequencing reveals Rickettsia, Coxiella, Francisella, Borrelia, Babesia, Theileria and Hemolivia species in ticks from Anatolia by Brinkmann, Annika, Hekimoğlu, Olcay, Dinçer, Ender, Hagedorn, Peter, Nitsche, Andreas, Ergünay, Koray

“…Ticks participate as arthropod vectors in the transmission of pathogenic microorganisms to humans. Several tick-borne infections have reemerged, along with…”
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