Search Results - "Hagan, Michael P"

Late Pelvic Toxicity After Bladder-Sparing Therapy in Patients With Invasive Bladder Cancer: RTOG 89-03, 95-06, 97-06, 99-06 by EFSTATHIOU, Jason A, BAE, Kyounghwa, SHIPLEY, William U, KAUFMAN, Donald S, HAGAN, Michael P, HENEY, Niall M, SANDLER, Howard M

“…In selected patients with muscle-invasive bladder cancer, combined-modality therapy (transurethral resection bladder tumor [TURBT], radiation therapy,…”
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Radiation-induced cell signaling: inside-out and outside-in by Valerie, Kristoffer, Yacoub, Adly, Hagan, Michael P, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

“…Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage as well as mitochondria-dependent generation of reactive oxygen…”
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Elective irradiation of pelvic lymph nodes during postprostatectomy salvage radiotherapy by Moghanaki, Drew, Koontz, Bridget F., Karlin, Jeremy D., Wan, Wen, Mukhopadhay, Nitai, Hagan, Michael P., Anscher, Mitchell S.

“…BACKGROUND: Success rates with salvage radiotherapy (SRT) in men who have a postprostatectomy biochemical relapse are suboptimal. One treatment‐intensification…”
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An efficient planning technique for low dose whole lung radiation therapy for covid-19 pandemic patients by Yuan, Lulin, Kim, Siyong, Palta, Jatinder, Hagan, Michael P.

“…•An efficient low dose whole lung RT technique developed for severe COVID-19 patients.•Empirical MU Calculation formula fitted from actual CT images of…”
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Bladder Preservation Therapy for Muscle‐Invading Bladder Cancers on Radiation Therapy Oncology Group Trials 8802, 8903, 9506, and 9706: Vascular Endothelial Growth Factor B Overexpression Predicts for Increased Distant Metastasis and Shorter Survival by Lautenschlaeger, Tim, George, Asha, Klimowicz, Alexander C., Efstathiou, Jason A., Wu, Chin‐Lee, Sandler, Howard, Shipley, William U., Tester, William J., Hagan, Michael P., Magliocco, Anthony M., Chakravarti, Arnab

“…Background. From 1988 to 1999, the Radiation Therapy Oncology Group (RTOG) conducted four prospective studies (8802, 8903, 9506, 9706) of patients with…”
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Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation by Martin, Aditi Pandya, Miller, Anna, Emad, Luni, Rahmani, Mohammed, Walker, Teneille, Mitchell, Clint, Hagan, Michael P, Park, Margaret A, Yacoub, Adly, Fisher, Paul B, Grant, Steven, Dent, Paul

“…We have defined some of the mechanisms by which the kinase inhibitor lapatinib kills HCT116 cells. Lapatinib inhibited radiation-induced activation of ERBB1/2,…”
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OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells by Park, Margaret A, Yacoub, Adly, Rahmani, Mohammed, Zhang, Guo, Hart, Lori, Hagan, Michael P, Calderwood, Stuart K, Sherman, Michael Y, Koumenis, Costas, Spiegel, Sarah, Chen, Ching-Shih, Graf, Martin, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

“…We have further defined mechanism(s) by which 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}acetamide [OSU-03012 (OSU)], a…”
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Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233 by Mak, Raymond H, Hunt, Daniel, Shipley, William U, Efstathiou, Jason A, Tester, William J, Hagan, Michael P, Kaufman, Donald S, Heney, Niall M, Zietman, Anthony L

“…Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive…”
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Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95 by Park, Margaret A, Zhang, Guo, Mitchell, Clint, Rahmani, Mohamed, Hamed, Hossein, Hagan, Michael P, Yacoub, Adly, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

“…Prior studies have noted that inhibitors of mitogen-activated protein kinase (MAPK) kinase 1/2 (MEK1/2) enhanced geldanamycin lethality in malignant…”
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Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling by Mitchell, Clint, Kabolizadeh, Peyman, Ryan, John, Roberts, John D, Yacoub, Adly, Curiel, David T, Fisher, Paul B, Hagan, Michael P, Farrell, Nicholas P, Grant, Steven, Dent, Paul

“…We have examined the mechanisms by which the multinuclear platinum chemotherapeutic BBR3610 kills human colon cancer cells. BBR3610 more efficiently killed…”
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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival by Carón, Rubén W, Yacoub, Adly, Li, Min, Zhu, Xiaoyu, Mitchell, Clint, Hong, Young, Hawkins, William, Sasazuki, Takehiko, Shirasawa, Senji, Kozikowski, Alan P, Dennis, Philip A, Hagan, Michael P, Grant, Steven, Dent, Paul

“…The abilities of mutated active RAS proteins to modulate cell survival following exposure to ionizing radiation and small molecule kinase inhibitors were…”
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Phase I/II trial of single-fraction high-dose-rate brachytherapy–boosted hypofractionated intensity-modulated radiation therapy for localized adenocarcinoma of the prostate by Myers, Michael A, Hagan, Michael P, Todor, Dorin, Gilbert, Lynn, Mukhopadhyay, Nitai, Randolf, Jessica, Heimiller, Jeffrey, Anscher, Mitchell S

“…Abstract Purpose A Phase I/II protocol was conducted to examine the toxicity and efficacy of the combination of intensity-modulated radiation therapy (IMRT)…”
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Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo by Hamed, Hossein, Hawkins, William, Mitchell, Clint, Gilfor, Donna, Zhang, Guo, Pei, Xin-Yan, Dai, Yun, Hagan, Michael P, Roberts, John D, Yacoub, Adly, Grant, Steven, Dent, Paul

“…The present studies were initiated to determine in greater molecular detail how MEK1/2 inhibitors [PD184352 and AZD6244 (ARRY-142886)] interact with UCN-01…”
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Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways by PARK, Jong-Sung, LIANG QIAO, HAGAN, Michael P, ELLIS, Earl, FISHER, Paul B, DENT, Paul, SU, Zao-Zong, HINMAN, Darin, WILLOUGHBY, Karen, MCKINSTRY, Robert, YACOUB, Adly, DUIGOU, Gregory J, YOUNG, Charles S. H, GRANT, Steven

“…We investigated the role of radiation-induced mitogen activated protein kinase (MAPK) pathway activity in the regulation of proliferation, cell survival and…”
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Radiotherapy-induced signal transduction by Yacoub, Adly, Miller, Anna, Caron, Ruben W, Qiao, Liang, Curiel, David A, Fisher, Paul B, Hagan, Michael P, Grant, Steven, Dent, Paul

“…Exposure of tumor cells to ionizing radiation causes compensatory activation of multiple intracellular survival signaling pathways to maintain viability. In…”
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MAPK pathways in radiation responses by Dent, Paul, Yacoub, Adly, Fisher, Paul B, Hagan, Michael P, Grant, Steven

“…Within the last 15 years, multiple new signal transduction pathways within cells have been discovered. Many of these pathways belong to what is now termed 'the…”
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Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment by Yacoub, Adly, Hawkins, William, Hanna, David, Young, Hong, Park, Margaret A, Grant, Mark, Roberts, John D, Curiel, David T, Fisher, Paul B, Valerie, Kristoffer, Grant, Steven, Hagan, Michael P, Dent, Paul

“…The impact of human chorionic gonadotropin (hCG) on prostate carcinoma viability was investigated. Treatment of LNCaP and PC-3 cells with hCG modestly reduced…”
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Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo by Hamed, Hossein, Mitchell, Clint, A. Park, Margaret, Hanna, David, Pandya Martin, Aditi, Harrison, Benjamin, Hawkins, William, Curiel, David, B. Fisher, Paul, Grant, Steven, Yacoub, Adly, P. Hagan, Michael, Dent, Paul

“…The ability of human chorionic gonadotropin (hCG) to modify prostate carcinoma viability in vitro and in vivo when combined with the HMG CoA reductase…”
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H-RAS V12–induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent by Carón, Rubén W, Yacoub, Adly, Zhu, Xiaoyu, Mitchell, Clint, Han, Song Iy, Sasazuki, Takehiko, Shirasawa, Senji, Hagan, Michael P, Grant, Steven, Dent, Paul

“…The abilities of mutated active K-RAS and H-RAS proteins, in an isogenic human carcinoma cell system, to modulate the activity of signaling pathways following…”
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Comparative study of late rectal toxicity in prostate cancer patients treated with low-dose-rate brachytherapy: With or without supplemental external beam radiotherapy by Serrano, Nicholas, Moghanaki, Drew, Asher, David, Karlin, Jeremy, Schutzer, Matthew, Chang, Michael, Hagan, Michael P

“…Abstract Purpose Supplemental external beam radiation therapy (sEBRT) is often prescribed in men undergoing low-dose-rate (LDR) brachytherapy. A population of…”
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