Search Results - "Haga, Yuya"

Reversible Drug Resistance Mechanisms in Non-small Cell Lung Cancer by Haga, Yuya

“…Although molecular targeted drugs are significantly effective in many types of cancer treatment, almost all patients suffer from drug resistance. For instance,…”
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Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis by Konishi, Hiroto, Haga, Yuya, Lin, Ying, Tsujino, Hirofumi, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR-TKIs), such as osimertinib, show great success in non-small-cell lung cancer patients with…”
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Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death by Manabe, Sota, Haga, Yuya, Tsujino, Hirofumi, Ikuno, Yudai, Asahara, Haruyasu, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Background Microplastics (MPs), plastic particles < 5 mm in size, are prevalent in the environment, and human exposure to them is inevitable. To assess the…”
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Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches by Ikuno, Yudai, Tsujino, Hirofumi, Haga, Yuya, Manabe, Sota, Idehara, Wakaba, Hokaku, Mii, Asahara, Haruyasu, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Microplastics, plastic particles 5 mm or less in size, are abundant in the environment; hence, the exposure of humans to microplastics is a great concern…”
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Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-negative breast cancer by Haga, Yuya, Higashisaka, Kazuma, Yang, Lili, Sekine, Naoki, Lin, Ying, Tsujino, Hirofumi, Nagano, Kazuya, Tsutsumi, Yasuo

“…Currently, the only therapeutic choice for the treatment of triple-negative breast cancer (TNBC) is chemotherapy. In TNBC, despite strong preclinical data,…”
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Fluorouracil exacerbates alpha-crystallin B chain—mediated cell migration in triple-negative breast cancer cell lines by Yang, Lili, Haga, Yuya, Nishimura, Akihide, Tsujii, Yuki, Tanahashi, Suzuno, Tsujino, Hirofumi, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Among triple-negative breast cancer (TNBC) subtypes, the basal-like 2 (BL2) subtype shows the lowest survival rate and the highest risk of metastasis after…”
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Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells by Lin, Ying, Higashisaka, Kazuma, Shintani, Takuya, Maki, Ayaka, Hanamuro, Sachiyo, Haga, Yuya, Maeda, Shinichiro, Tsujino, Hirofumi, Nagano, Kazuya, Fujio, Yasushi, Tsutsumi, Yasuo

“…In non-small-cell lung cancer, mutation of epidermal growth factor receptor (EGFR) stimulates cell proliferation and survival. EGFR tyrosine kinase inhibitors…”
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Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors by Haga, Yuya, Marrocco, Ilaria, Noronha, Ashish, Uribe, Mary Luz, Nataraj, Nishanth Belugali, Sekar, Arunachalam, Drago-Garcia, Diana, Borgoni, Simone, Lindzen, Moshit, Giri, Suvendu, Wiemann, Stefan, Tsutsumi, Yasuo, Yarden, Yosef

“…Lung cancers driven by mutant forms of EGFR invariably develop resistance to kinase inhibitors, often due to secondary mutations. Here we describe an…”
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非小細胞肺がんにおける可逆的薬剤耐性細胞の解析 by 芳賀, 優弥

“…「1. はじめに」わが国における死因別死亡者数は依然として, 悪性腫瘍(がん)が第一位である. 近年, 分子標的医薬や免疫チェックポイント阻害剤, コンパニオン診断薬と対象の薬剤を組み合わせることによる個別化医療(Personalized Medicine)が飛躍的に進歩している. 中でも,…”
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Valproic acid elevates HIF-1α-mediated CGB expression and suppresses glucose uptake in BeWo cells by Kitahara, Go, Higashisaka, Kazuma, Nakamoto, Yurina, Yamamoto, Rena, Okuno, Wakako, Serizawa, Momoe, Sakahashi, Yuji, Tsujino, Hirofumi, Haga, Yuya, Tsutsumi, Yasuo

“…Placental dysfunction can disrupt pregnancy. However, few studies have assessed the effects of chemical-induced toxicity on placental function. Here, we…”
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Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice by Saeki, Yuma, Higashisaka, Kazuma, Izutani, Rina, Seo, Jiwon, Miyaji, Kazuki, Haga, Yuya, Tsutsumi, Yasuo

“…Given that daily exposure to nanoparticles is now unavoidable, there are concerns that nanoparticles have unexpected biological effects due to their small…”
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Impact of Degradation of Polyethylene Particles on Their Cytotoxicity by Ikuno, Yudai, Tsujino, Hirofumi, Haga, Yuya, Asahara, Haruyasu, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Microplastics are ubiquitous in the environment, including in the ocean, soil, and air. Therefore, there are concerns regarding human exposure. Since it is…”
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Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells by Konishi, Hiroto, Haga, Yuya, Okumura, Moe, Tsujino, Hirofumi, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Various treatment options, such as molecular targeted drugs and immune checkpoint blockades, are available for patients with cancer. However, some cancer types…”
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ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma by Srivastava, Swati, Nataraj, Nishanth Belugali, Sekar, Arunachalam, Ghosh, Soma, Bornstein, Chamutal, Drago-Garcia, Diana, Roth, Lee, Romaniello, Donatella, Marrocco, Ilaria, David, Eyal, Gilad, Yuval, Lauriola, Mattia, Rotkopf, Ron, Kimchi, Adi, Haga, Yuya, Tsutsumi, Yasuo, Mirabeau, Olivier, Surdez, Didier, Zinovyev, Andrei, Delattre, Olivier, Kovar, Heinrich, Amit, Ido, Yarden, Yosef

“…The glucocorticoid receptor (GR) acts as a ubiquitous cortisol-dependent transcription factor (TF). To identify co-factors, we used protein-fragment…”
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Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells by Yamaguchi, Shintaro, Isaka, Ryo, Sakahashi, Yuji, Tsujino, Hirofumi, Haga, Yuya, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Nanoparticles are being used in an increasing number of applications in a wide range of fields; however, these particles can migrate to the brain, raising…”
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Preparation of Degraded Microplastics That Imitate Surface Properties in the Environment by Tsujino, Hirofumi, Ikuno, Yudai, Haga, Yuya, Asahara, Haruyasu, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Microplastics are small pieces of plastic that are less than 5 mm in length. These plastics have been detected in various environments, including the ocean,…”
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib by Simoni-Nieves, Arturo, Lindzen, Moshit, Giri, Suvendu, Gupta, Nitin, Chatterjee, Rishita, Selvadurai, Boobash-Raj, Van Daele, Marieke, Love, Danielle, Haga, Yuya, Romaniello, Donatella, Salame, Tomer-Meir, Zerbib, Mirie, Oren, Roni, Tsutsumi, Yasuo, Lauriola, Mattia, Marrocco, Ilaria, Yarden, Yosef

“…Activating EGFR (epidermal growth factor receptor) mutations can be inhibited by specific tyrosine kinase inhibitors (TKIs), which have changed the landscape…”
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環境中の表面性状を模倣した劣化マイクロプラスチックの作製 by 辻野, 博文, 生野, 雄大, 芳賀, 優弥, 淺原, 時泰, 東阪, 和馬, 堤, 康央

“…「1. はじめに」マイクロプラスチックは5mm以下のプラスチック粒子であり, 海洋, 土壌, 空気などの様々な環境中から検出されていることから, ヒトを含めた生物への影響が懸念されている. 魚は食物連鎖を通じて水中のマイクロプラスチックを意図せず摂取することが知られており,…”
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劣化したマイクロプラスチックが示す細胞毒性機序の解明 by 芳賀, 優弥, 真鍋, 颯太, 辻野, 博文, 淺原, 時泰, 東阪, 和馬, 堤, 康央

“…「1. はじめに」近年, sustainable development goals (SDGs) の目標14「海の豊かさを守ろう」にも取り上げられているように海洋汚染の抑制に向けた動きが盛んである. 中でも, 環境中に漏出したプラスチックゴミに関する懸念は日々高まっており,…”
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Reversible Drug Resistance Mechanisms in Non-small Cell Lung Cancer by Haga, Yuya

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