A review of controlled drug delivery systems based on cells and cell membranes

A review of controlled drug delivery systems based on cells and cell membranes

Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the applicati...

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Bibliographic Details
Published in:Journal of medical signals and sensors Vol. 9; no. 3; pp. 181 - 189
Main Authors: Zargar, Seyed, Hafshejani, Darioush, Eskandarinia, Asghar, Rafienia, Mohamad, Kharazi, Anousheh
Format: Journal Article
Language:English
Published: India Wolters Kluwer - Medknow Publications 01-07-2019
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects:
Cell membranes
Drug delivery
Drug delivery systems
Drugs
erythrocytes
macrophages
Novels
Patient compliance
platelets
Regulatory compliance
Review
stem cells
stem cells
macrophages
Drug delivery
erythrocytes
platelets
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Summary:Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2228-7477
2228-7477
DOI:10.4103/jmss.JMSS_53_18