Search Results - "Hafler, DA"

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping by Sawcer, Stephen J, Maranian, Mel, Singlehurst, Sara, Yeo, TaiWai, Compston, Alastair, Daly, Mark J, De Jager, Philip L, Gabriel, Stacey, Hafler, David A, Ivinson, Adrian J, Lander, Eric S, Rioux, John D, Walsh, Emily, Gregory, Simon G, Schmidt, Silke, Pericak-Vance, Margaret A, Barcellos, Lisa, Hauser, Stephen L, Oksenberg, Jorge R, Kenealy, Shannon J, Haines, Jonathan L

“…To explore the potential value of recently developed high-density linkage mapping methods in the analysis of complex disease we have regenotyped five nuclear…”
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Class II HLA interactions modulate genetic risk for multiple sclerosis by Moutsianas, Loukas, Jostins, Luke, Beecham, Ashley H, Dilthey, Alexander T, Xifara, Dionysia K, Ban, Maria, Shah, Tejas S, Patsopoulos, Nikolaos A, Alfredsson, Lars, Anderson, Carl A, Attfield, Katherine E, Baranzini, Sergio E, Barrett, Jeffrey, Binder, Thomas M C, Booth, David, Buck, Dorothea, Celius, Elisabeth G, Cotsapas, Chris, D'Alfonso, Sandra, Dendrou, Calliope A, Donnelly, Peter, Dubois, Bénédicte, Fontaine, Bertrand, Fugger, Lars, Goris, An, Gourraud, Pierre-Antoine, Graetz, Christiane, Hemmer, Bernhard, Hillert, Jan, Kockum, Ingrid, Leslie, Stephen, Lill, Christina M, Martinelli-Boneschi, Filippo, Oksenberg, Jorge R, Olsson, Tomas, Oturai, Annette, Saarela, Janna, Søndergaard, Helle Bach, Spurkland, Anne, Taylor, Bruce, Winkelmann, Juliane, Zipp, Frauke, Haines, Jonathan L, Pericak-Vance, Margaret A, Spencer, Chris C A, Stewart, Graeme, Hafler, David A, Ivinson, Adrian J, Harbo, Hanne F, Hauser, Stephen L, De Jager, Philip L, Compston, Alastair, McCauley, Jacob L, Sawcer, Stephen, McVean, Gil

“…Gil McVean and colleagues report a meta-analysis of Immunochip studies including over 17,000 multiple sclerosis cases and 30,000 controls, with imputation of…”
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Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis by Viglietta, Vissia, Baecher-Allan, Clare, Weiner, Howard L, Hafler, David A

“…CD4+CD25+ regulatory T cells contribute to the maintenance of peripheral tolerance by active suppression because their deletion causes spontaneous autoimmune…”
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Pervasive sharing of genetic effects in autoimmune disease by Cotsapas, Chris, Voight, Benjamin F, Rossin, Elizabeth, Lage, Kasper, Neale, Benjamin M, Wallace, Chris, Abecasis, Gonçalo R, Barrett, Jeffrey C, Behrens, Timothy, Cho, Judy, De Jager, Philip L, Elder, James T, Graham, Robert R, Gregersen, Peter, Klareskog, Lars, Siminovitch, Katherine A, van Heel, David A, Wijmenga, Cisca, Worthington, Jane, Todd, John A, Hafler, David A, Rich, Stephen S, Daly, Mark J

“…Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk…”
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Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects by Patsopoulos, Nikolaos A, Barcellos, Lisa F, Hintzen, Rogier Q, Schaefer, Catherine, van Duijn, Cornelia M, Noble, Janelle A, Raj, Towfique, Gourraud, Pierre-Antoine, Stranger, Barbara E, Oksenberg, Jorge, Olsson, Tomas, Taylor, Bruce V, Sawcer, Stephen, Hafler, David A, Carrington, Mary, De Jager, Philip L, de Bakker, Paul I W

“…The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect,…”
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T cell anergy by LaSalle, J M, Hafler, D A

“…T cell clonal anergy is a proposed mechanism of immunologic self tolerance in which T cells become functionally inactivated after previous stimulation. MHC…”
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Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity by Shinoda, Koji, Li, Rui, Rezk, Ayman, Mexhitaj, Ina, Patterson, Kristina R, Kakara, Mihir, Zuroff, Leah, Bennett, Jeffrey L, von Büdingen, H-Christian, Carruthers, Robert, Edwards, Keith R, Fallis, Robert, Giacomini, Paul S, Greenberg, Benjamin M, Hafler, David A, Ionete, Carolina, Kaunzner, Ulrike W, Lock, Christopher B, Longbrake, Erin E, Pardo, Gabriel, Piehl, Fredrik, Weber, Martin S, Ziemssen, Tjalf, Jacobs, Dina, Gelfand, Jeffrey M, Cross, Anne H, Cameron, Briana, Musch, Bruno, Winger, Ryan C, Jia, Xiaoming, Harp, Christopher T, Herman, Ann, Bar-Or, Amit

“…A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This activity does not recur with…”
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Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving by Han, Qing, Bradshaw, Elizabeth M, Nilsson, Björn, Hafler, David A, Love, J Christopher

“…The large diversity of cells that comprise the human immune system requires methods that can resolve the individual contributions of specific subsets to an…”
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Inhibition of human CD4(+)CD25(+high) regulatory T cell function by Baecher-Allan, Clare, Viglietta, Vissia, Hafler, David A

“…CD4(+)CD25(+high) T cells are potent regulators of autoreactive T cells. However, it is unclear how regulatory CD4(+)CD25(+high) cells discriminate between…”
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Suppressor T cells in human diseases by Baecher-Allan, Clare, Hafler, David A

“…Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of…”
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Human CD4+CD25+ regulatory T cells by Baecher-Allan, Clare, Viglietta, Vissia, Hafler, David A

“…In this report, we review studies of human CD4+CD25+ regulatory T cells (T-reg). Although lagging a few years behind the discovery of these cells in the mouse,…”
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Two independent alleles at 6q23 associated with risk of rheumatoid arthritis by Plenge, Robert M, Cotsapas, Chris, Davies, Leela, Price, Alkes L, de Bakker, Paul I W, Maller, Julian, Pe'er, Itsik, Burtt, Noel P, Blumenstiel, Brendan, DeFelice, Matt, Parkin, Melissa, Barry, Rachel, Winslow, Wendy, Healy, Claire, Graham, Robert R, Neale, Benjamin M, Izmailova, Elena, Roubenoff, Ronenn, Parker, Alexander N, Glass, Roberta, Karlson, Elizabeth W, Maher, Nancy, Hafler, David A, Lee, David M, Seldin, Michael F, Remmers, Elaine F, Lee, Annette T, Padyukov, Leonid, Alfredsson, Lars, Coblyn, Jonathan, Weinblatt, Michael E, Gabriel, Stacey B, Purcell, Shaun, Klareskog, Lars, Gregersen, Peter K, Shadick, Nancy A, Daly, Mark J, Altshuler, David

“…To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397 individuals with rheumatoid arthritis for 116,204 SNPs and carried…”
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Genetic mapping across autoimmune diseases reveals shared associations and mechanisms by Lincoln, Matthew R., Connally, Noah, Axisa, Pierre-Paul, Gasperi, Christiane, Mitrovic, Mitja, van Heel, David, Wijmenga, Cisca, Withoff, Sebo, Jonkers, Iris H., Padyukov, Leonid, Rich, Stephen S., Graham, Robert R., Gaffney, Patrick M., Langefeld, Carl D., Vyse, Timothy J., Hafler, David A., Chun, Sung, Sunyaev, Shamil R., Cotsapas, Chris

“…Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited…”
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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope by Chen, Yahua, Ricordi, Camillo, Clemmings, Sue M, Hafler, David A, Hering, Bernhard J, Kenyon, Norma Sue, Kent, Sally C, Bregoli, Lisa

“…In autoimmune type 1 diabetes, pathogenic T lymphocytes are associated with the specific destruction of insulin-producing β-islet cells. Identification of the…”
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Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases by Rioux, John D, Goyette, Philippe, Vyse, Timothy J, Hammarström, Lennart, Fernando, Michelle M.A, Green, Todd, De Jager, Philip L, Foisy, Sylvain, Wang, Joanne, de Bakker, Paul I.W, Leslie, Stephen, McVean, Gilean, Padyukov, Leonid, Alfredsson, Lars, Annese, Vito, Hafler, David A, Pan-Hammarström, Qiang, Matell, Ritva, Sawcer, Stephen J, Compston, Alastair D, Cree, Bruce A.C, Mirel, Daniel B, Daly, Mark J, Behrens, Tim W, Klareskog, Lars, Gregersen, Peter K, Oksenberg, Jorge R, Hauser, Stephen L

“…The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been…”
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T cells in multiple sclerosis and inflammatory central nervous system diseases by Hafler, D A, Weiner, H L

“…Using murine monoclonal antibodies to mark total T cells, we have found rapid migration of T cells into the CSF in progressive multiple sclerosis patients,…”
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Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4 +CD25 + T cells by Baecher-Allan, Clare, Wolf, Elizabeth, Hafler, David A.

“…The importance of CD4 +CD25 + regulatory T cells (Treg) in maintaining immune homeostasis has been directly demonstrated in vivo by their manipulation in a…”
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Methods for High-Density Admixture Mapping of Disease Genes by Patterson, Nick, Hattangadi, Neil, Lane, Barton, Lohmueller, Kirk E., Hafler, David A., Oksenberg, Jorge R., Hauser, Stephen L., Smith, Michael W., O’Brien, Stephen J., Altshuler, David, Daly, Mark J., Reich, David

“…Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) has been proposed as an efficient approach to localizing…”
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An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity by Ottoboni, Linda, Keenan, Brendan T, Tamayo, Pablo, Kuchroo, Manik, Mesirov, Jill P, Buckle, Guy J, Khoury, Samia J, Hafler, David A, Weiner, Howard L, De Jager, Philip L

“…The multiple sclerosis (MS) patient population is highly heterogeneous in terms of disease course and treatment response. We used a transcriptional profile…”
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A High-Density Admixture Map for Disease Gene Discovery in African Americans by Smith, Michael W., Patterson, Nick, Lautenberger, James A., Truelove, Ann L., McDonald, Gavin J., Waliszewska, Alicja, Kessing, Bailey D., Malasky, Michael J., Scafe, Charles, Le, Ernest, De Jager, Philip L., Mignault, Andre A., Yi, Zeng, de Thé, Guy, Essex, Myron, Sankalé, Jean-Louis, Moore, Jason H., Poku, Kwabena, Phair, John P., Goedert, James J., Vlahov, David, Williams, Scott M., Tishkoff, Sarah A., Winkler, Cheryl A., De La Vega, Francisco M., Woodage, Trevor, Sninsky, John J., Hafler, David A., Altshuler, David, Gilbert, Dennis A., O’Brien, Stephen J., Reich, David

“…Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) provides a way of localizing genes that cause disease, in admixed…”
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