Search Results - "Hafler, Brian P"

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration by Menon, Madhvi, Mohammadi, Shahin, Davila-Velderrain, Jose, Goods, Brittany A., Cadwell, Tanina D., Xing, Yu, Stemmer-Rachamimov, Anat, Shalek, Alex K., Love, John Christopher, Kellis, Manolis, Hafler, Brian P.

“…Genome-wide association studies (GWAS) have identified genetic variants associated with age-related macular degeneration (AMD), one of the leading causes of…”
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Single-cell analysis reveals inflammatory interactions driving macular degeneration by Kuchroo, Manik, DiStasio, Marcello, Song, Eric, Calapkulu, Eda, Zhang, Le, Ige, Maryam, Sheth, Amar H., Majdoubi, Abdelilah, Menon, Madhvi, Tong, Alexander, Godavarthi, Abhinav, Xing, Yu, Gigante, Scott, Steach, Holly, Huang, Jessie, Huguet, Guillaume, Narain, Janhavi, You, Kisung, Mourgkos, George, Dhodapkar, Rahul M., Hirn, Matthew J., Rieck, Bastian, Wolf, Guy, Krishnaswamy, Smita, Hafler, Brian P.

“…Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therapies for…”
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Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates by Hafler, Brian P, Surzenko, Natalia, Beier, Kevin T, Punzo, Claudio, Trimarchi, Jeffrey M, Kong, Jennifer H, Cepko, Constance L

“…Previous lineage analyses have shown that retinal progenitor cells (RPCs) are multipotent throughout development, and expression-profiling studies have shown a…”
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Innate immune biology in age-related macular degeneration by Ascunce, Karina, Dhodapkar, Rahul M, Huang, Deven, Hafler, Brian P

“…Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not…”
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Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation by Grutzendler, Jaime, Murikinati, Sasidhar, Hiner, Bennett, Ji, Lingling, Lam, Carson K, Yoo, Taehwan, Gupta, Shobhana, Hafler, Brian P, Adelman, Ron A, Yuan, Peng, Rodriguez, Guadalupe

“…Occlusion of the microvasculature by blood clots, atheromatous fragments, or circulating debris is a frequent phenomenon in most human organs. Emboli are…”
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CLINICAL PROGRESS IN INHERITED RETINAL DEGENERATIONS: GENE THERAPY CLINICAL TRIALS AND ADVANCES IN GENETIC SEQUENCING by Hafler, Brian P

“…Inherited retinal dystrophies are a significant cause of vision loss and are characterized by the loss of photoreceptors and the retinal pigment epithelium…”
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Single-cell transcriptomic analysis of Alzheimer’s disease by Mathys, Hansruedi, Davila-Velderrain, Jose, Peng, Zhuyu, Gao, Fan, Mohammadi, Shahin, Young, Jennie Z., Menon, Madhvi, He, Liang, Abdurrob, Fatema, Jiang, Xueqiao, Martorell, Anthony J., Ransohoff, Richard M., Hafler, Brian P., Bennett, David A., Kellis, Manolis, Tsai, Li-Huei

“…Alzheimer’s disease is a pervasive neurodegenerative disorder, the molecular complexity of which remains poorly understood. Here, we analysed 80,660…”
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Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies by Cheng, Shun-Yun, Cipi, Joris, Ma, Shan, Hafler, Brian P., Kanadia, Rahul N., Brush, Richard S., Agbaga, Martin-Paul, Punzo, Claudio

“…Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. While the histopathology of the different disease stages is well…”
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Glial-mediated neuroinflammatory mechanisms in age-related macular degeneration by Dhodapkar, Rahul M., Martell, Diego, Hafler, Brian P.

“…Age-related macular degeneration (AMD) is a neurodegenerative disorder characterized by photoreceptor and retinal pigment epithelium loss often complicated by…”
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Expression and function of Nkx6.3 in vertebrate hindbrain by Hafler, Brian P, Choi, Michael Y, Shivdasani, Ramesh A, Rowitch, David H

“…Abstract Homeodomain transcription factors serve important functions in organogenesis and tissue differentiation, particularly with respect to the positional…”
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A T Cell Receptor Antagonist Peptide Induces T Cells that Mediate Bystander Suppression and Prevent Autoimmune Encephalomyelitis Induced with Multiple Myelin Antigens by Nicholson, Lindsay B., Murtaza, Anwar, Hafler, Brian P., Sette, Alessandro, Kuchroo, Vijay K.

“…Experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) residues 139-151 (HSLGKWLGHPDKF) can be prevented by treatment…”
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Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice by Hafler, Brian P, Klein, Zoe A, Jimmy Zhou, Z, Strittmatter, Stephen M

“…Abstract Prior investigations have shown that patients with neuronal ceroid lipofuscinosis (NCL) develop neurodegeneration characterized by vision loss, motor…”
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Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity by Benchabane, Hassina, Xin, Nan, Tian, Ai, Hafler, Brian P, Nguyen, Kerrie, Ahmed, Ayah, Ahmed, Yashi

“…Wnt/Wingless signal transduction directs fundamental developmental processes, and upon hyperactivation triggers colorectal adenoma/carcinoma formation…”
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Author Correction: Single-cell transcriptomic analysis of Alzheimer’s disease by Mathys, Hansruedi, Davila-Velderrain, Jose, Peng, Zhuyu, Gao, Fan, Mohammadi, Shahin, Young, Jennie Z., Menon, Madhvi, He, Liang, Abdurrob, Fatema, Jiang, Xueqiao, Martorell, Anthony J., Ransohoff, Richard M., Hafler, Brian P., Bennett, David A., Kellis, Manolis, Tsai, Li-Huei

“…Change history: In this Article, the Acknowledgements section should have included that the work was supported in part by the Cure Alzheimer’s Fund (CAF), and…”
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Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk -associated retinitis pigmentosa by Mercau, Maria E, Akalu, Yemsratch T, Mazzoni, Francesca, Gyimesi, Gavin, Alberto, Emily J, Kong, Yong, Hafler, Brian P, Finnemann, Silvia C, Rothlin, Carla V, Ghosh, Sourav

“…Severe, early-onset photoreceptor (PR) degeneration associated with mutations is thought to result from failed phagocytosis by retinal pigment epithelium…”
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Course of Ocular Function in PRPF31 Retinitis Pigmentosa by Hafler, Brian P., Comander, Jason, Weigel DiFranco, Carol, Place, Emily M., Pierce, Eric A.

“…Mutations in pre-mRNA splicing factors are the second most common cause of autosomal dominant retinitis pigmentosa, and a major cause of vision loss. The…”
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Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube by Sun, Tao, Hafler, Brian P., Kaing, Sovann, Kitada, Masaaki, Ligon, Keith L., Widlund, Hans R., Yuk, Dong-in, Stiles, Charles D., Rowitch, David H.

“…Within the motoneuron precursor (pMN) domain of the developing spinal cord, the bHLH transcription factor, Olig2, plays critical roles in pattern formation and…”
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R-Spondin 1 Suppresses Inflammatory Cytokine Production in Human Cortical Astrocytes by Logan, Robert, Bhatta, Sagar, Sutova, Hande Eda, Hafler, Brian P., Miller, Sean J.

“…Background/Objectives: Wnt signaling pathways are essential in various biological processes, including embryonic development and tissue homeostasis, and are…”
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Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating [beta]-catenin-TCF activity by Benchabane, Hassina, Xin, Nan, Tian, Ai, Hafler, Brian P, Nguyen, Kerrie, Ahmed, Ayah, Ahmed, Yashi

“…Wingless signal transduction directs fundamental developmental processes, and upon hyperactivation triggers colorectal adenoma/carcinoma formation. Responses…”
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Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity: Jerky/Ebd1 facilitates Wnt/Wingless signalling by Benchabane, Hassina, Xin, Nan, Tian, Ai, Hafler, Brian P, Nguyen, Kerrie, Ahmed, Ayah, Ahmed, Yashi

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