LIPID-LOWERING EFFICACY OF 20 MG SIMVASTATIN VERSUS 5 MG ROSUVASTATIN IN PATIENTS OF TYPE 2 DIABETES

Abstract Objective: To compare the efficacy of Rosuvastatin 5mg and Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed patients with type 2 diabetes. Study Design: Quasi-experimental study. Place and Duration of Study: Department of General Medicine, Pak Emirates Mil...

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Bibliographic Details
Published in:	Pakistan Armed Forces medical journal Vol. 70; no. 4; pp. 885 - 889
Main Authors:	Hafiz Muhammad Yasir Rehman, Abdul Latif Khattak, Taimoor Ashraf Khan, Abdul Moueed Tariq, Shahzeb Ahmed Satti, Rafi Ud Din
Format:	Journal Article
Language:	English
Published:	Knowledge Bylanes 31-08-2020 Army Medical College Rawalpindi
Subjects:	Cholesterol hmg-coa reductase inhibitor lipid-lowering efficacy Low density lipoproteins low-density lipoprotein cholesterol Rosuvastatin Simvastatin Type 2 diabetes Pakistan
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Summary:	Abstract Objective: To compare the efficacy of Rosuvastatin 5mg and Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed patients with type 2 diabetes. Study Design: Quasi-experimental study. Place and Duration of Study: Department of General Medicine, Pak Emirates Military Hospital (PEMH), Rawalpindi, from Jul 2017 to Jan 2018. Methodology: Patients of type 2 diabetes with hypercholesterolemia (mean LDL-C levels >100 mg/dl) were included in the study. In a sample of 100 patients, half of the patients were in the Rosuvastatin 5mg group (group A) while half patients were in the Simvastatin 20mg group (group B). Non-probability consecutive sampling was done. We followed up the patients for 6 weeks. All the laboratory investigations were performed from the laboratory of the same hospital. Investigator himself recorded all the information including name, age, gender, weight, LDL-C levels, Renal function test reports and CK-MB levels in a self-designed, self-administered proforma. Data were analyzed with statistical analysis program SPSS V 23. Results: Age range in this study was from 35 to 60 years with a mean age of 46.980 ± 6.31 years in group A vs 48.520 ± 5.61 years in group B. Mean LDL-C Levels were 149.460 ± 25.76 mg/dl in group A vs 146.960 ± 22.92 mg/dl in group B. Mean weight was 82.880 ± 9.17 kg in group A vs 88.660 ± 10.33kg in group B. Male gender was dominant in both group (70% and 72%). In group A, efficacy was seen in 40 (80%) patients as compared to 24 (48%) patients in group B (p<0.001). Conclusion: Rosuvastatin 5mg tablet was more effective than Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed type 2 diabetes patients.
ISSN:	0030-9648 2411-8842