Search Results - "Hafalla, Julius C."

The ecology of immune state in a wild mammal, Mus musculus domesticus by Abolins, Stephen, Lazarou, Luke, Weldon, Laura, Hughes, Louise, King, Elizabeth C, Drescher, Paul, Pocock, Michael J O, Hafalla, Julius C R, Riley, Eleanor M, Viney, Mark

“…The immune state of wild animals is largely unknown. Knowing this and what affects it is important in understanding how infection and disease affects wild…”
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Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease by de Souza, J Brian, Hafalla, Julius C R, Riley, Eleanor M, Couper, Kevin N

“…Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding…”
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The comparative immunology of wild and laboratory mice, Mus musculus domesticus by Abolins, Stephen, King, Elizabeth C., Lazarou, Luke, Weldon, Laura, Hughes, Louise, Drescher, Paul, Raynes, John G., Hafalla, Julius C. R., Viney, Mark E., Riley, Eleanor M.

“…The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect…”
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Measures of immune function of wild mice, Mus musculus by ABOLINS, STEPHEN R., POCOCK, MICHAEL J. O., HAFALLA, JULIUS C. R., RILEY, ELEANOR M., VINEY, MARK E.

“…The immune function of wild animals has been rather little studied. Wild animals’ immune function may differ from that of laboratory bred animals because of…”
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Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation by Couper, Kevin N, Barnes, Tom, Hafalla, Julius C R, Combes, Valery, Ryffel, Bernhard, Secher, Thomas, Grau, Georges E, Riley, Eleanor M, de Souza, J Brian

“…There is considerable debate as to the nature of the primary parasite-derived moieties that activate innate pro-inflammatory responses during malaria…”
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Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling by Claser, Carla, De Souza, J Brian, Thorburn, Samuel G, Grau, Georges Emile, Riley, Eleanor M, Rénia, Laurent, Hafalla, Julius C R

“…The resolution of malaria infection is dependent on a balance between proinflammatory and regulatory immune responses. While early effector T cell responses…”
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IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection by Couper, Kevin N, Blount, Daniel G, Wilson, Mark S, Hafalla, Julius C, Belkaid, Yasmine, Kamanaka, Masahito, Flavell, Richard A, de Souza, J Brian, Riley, Eleanor M

“…The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective…”
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IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain by Villegas-Mendez, Ana, Greig, Rachel, Shaw, Tovah N, de Souza, J Brian, Gwyer Findlay, Emily, Stumhofer, Jason S, Hafalla, Julius C R, Blount, Daniel G, Hunter, Christopher A, Riley, Eleanor M, Couper, Kevin N

“…It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6…”
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Long-lived memory B-cell responses following BCG vaccination by Sebina, Ismail, Cliff, Jacqueline M, Smith, Steven G, Nogaro, Sarah, Webb, Emily L, Riley, Eleanor M, Dockrell, Hazel M, Elliott, Alison M, Hafalla, Julius C R, Cose, Stephen

“…The role of T-cells in immunity against Mycobacterium tuberculosis (M. tuberculosis) infection has been extensively studied, however, that of B-cells still…”
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The breadth, but not the magnitude, of circulating memory B cell responses to P. falciparum increases with age/exposure in an area of low transmission by Nogaro, Sarah I, Hafalla, Julius C, Walther, Brigitte, Remarque, Edmond J, Tetteh, Kevin K A, Conway, David J, Riley, Eleanor M, Walther, Michael

“…Malaria caused by Plasmodium falciparum remains a major cause of death in sub-Saharan Africa. Immunity against symptoms of malaria requires repeated exposure,…”
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Macrophage-Mediated but Gamma Interferon-Independent Innate Immune Responses Control the Primary Wave of Plasmodium yoelii Parasitemia by Couper, Kevin N, Blount, Daniel G, Hafalla, Julius C.R, van Rooijen, Nico, de Souza, J. Brian, Riley, Eleanor M

“…In most models of blood-stage malaria infection, proinflammatory immune responses are required for control of infection and elimination of parasites. We…”
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Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine by Horowitz, Amir, Hafalla, Julius C R, King, Elizabeth, Lusingu, John, Dekker, Denise, Leach, Amanda, Moris, Philippe, Cohen, Joe, Vekemans, Johan, Villafana, Tonya, Corran, Patrick H, Bejon, Philip, Drakeley, Chris J, von Seidlein, Lorenz, Riley, Eleanor M

“…RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergoing clinical trials. We report an analysis of cellular immune…”
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Migration of Plasmodium Sporozoites through Cells before Infection by Mota, Maria M., Pradel, Gabriele, Vanderberg, Jerome P., Julius C. R. Hafalla, Frevert, Ute, Nussenzweig, Ruth S., Nussenzweig, Victor, Rodríguez, Ana

“…Intracellular bacteria and parasites typically invade host cells through the formation of an internalization vacuole around the invading pathogen. Plasmodium…”
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Conservation of S20 as an Ineffective and Disposable IFNγ-Inducing Determinant of Plasmodium Sporozoites Indicates Diversion of Cellular Immunity by Hon, Calvin, Friesen, Johannes, Ingmundson, Alyssa, Scheppan, Diana, Hafalla, Julius C. R., Müller, Katja, Matuschewski, Kai

“…Despite many decades of research to develop a malaria vaccine, only one vaccine candidate has been explored in pivotal phase III clinical trials. This…”
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Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection by Findlay, Emily Gwyer, Greig, Rachel, Stumhofer, Jason S, Hafalla, Julius C R, de Souza, J Brian, Saris, Christiaan J, Hunter, Christopher A, Riley, Eleanor M, Couper, Kevin N

“…Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to…”
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Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria by Newman, Kirsty C, Korbel, Daniel S, Hafalla, Julius C, Riley, Eleanor M

“…Data from a variety of experimental models suggest that natural killer (NK) cells require signals from accessory cells in order to respond optimally to…”
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Genomic analysis of Salmonella enterica from Metropolitan Manila abattoirs and markets reveals insights into circulating virulence and antimicrobial resistance genotypes by Mora, Jonah Feliza B, Meclat, Vanessa Yvonne B, Calayag, Alyzza Marie B, Campino, Susana, Hafalla, Julius C R, Hibberd, Martin L, Phelan, Jody E, Clark, Taane G, Rivera, Windell L

“…The integration of next-generation sequencing into the identification and characterization of resistant and virulent strains as well as the routine…”
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Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection by Villegas-Mendez, Ana, de Souza, J Brian, Murungi, Linda, Hafalla, Julius C R, Shaw, Tovah N, Greig, Rachel, Riley, Eleanor M, Couper, Kevin N

“…IFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the…”
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Short-lived IFN-γ effector responses, but long-lived IL-10 memory responses, to malaria in an area of low malaria endemicity by Wipasa, Jiraprapa, Okell, Lucy, Sakkhachornphop, Supachai, Suphavilai, Chaisuree, Chawansuntati, Kriangkrai, Liewsaree, Witaya, Hafalla, Julius C R, Riley, Eleanor M

“…Immunity to malaria is widely believed to wane in the absence of reinfection, but direct evidence for the presence or absence of durable immunological memory…”
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Efficient Development of Plasmodium Liver Stage-Specific Memory CD8⁺ T Cells during the Course of Blood-Stage Malarial Infection by Hafalla, Julius C. R., Rai, Urvashi, Bernal-Rubio, Dabeiba, Rodriguez, Ana, Zavala, Fidel

“…Immunity to Plasmodium liver stages in individuals in malaria-endemic areas is inextricably linked to concomitant blood-stage parasitemia. Although Plasmodium…”
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