Search Results - "Haenen, G"

Paracetamol as a Post Prandial Marker for Gastric Emptying, A Food-Drug Interaction on Absorption by Bartholomé, R, Salden, B, Vrolijk, M F, Troost, F J, Masclee, A, Bast, A, Haenen, G R

“…The use of paracetamol as tool to determine gastric emptying was evaluated in a cross over study. Twelve healthy volunteers were included and each of them…”
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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress by Brouwers, O, Niessen, P. M, Haenen, G, Miyata, T, Brownlee, M, Stehouwer, C. D, De Mey, J. G, Schalkwijk, C. G

“…Aims/hypothesis Impaired nitric oxide (NO)-dependent vasorelaxation plays a key role in the development of diabetic vascular complications. We investigated the…”
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Randomised clinical study: Aspergillus niger‐derived enzyme digests gluten in the stomach of healthy volunteers by Salden, B. N., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., Masclee, A. A.

“…Summary Background Aspergillus niger prolyl endoprotease (AN‐PEP) efficiently degrades gluten molecules into non‐immunogenic peptides in vitro. Aim To assess…”
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Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene by Shi, Q., Haenen, G. R., Maas, L., Arlt, V. M., Spina, D., Vasquez, Y. Riffo, Moonen, E., Veith, C., Van Schooten, F. J., Godschalk, R. W. L.

“…Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we…”
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Effect of Interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells by Shi, Q, Boots, A.W, Maas, L, Veith, C, van Kuijk, K, Haenen, G.R, Godschalk, R.W, Van Schooten, F.J

“…Abstract It has been well established that inflammation and concurrent mutagenic exposures drive the carcinogenic process in a synergistic way. To elucidate…”
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Chemical characteristics for optimizing CYP2E1 inhibition by van de Wier, B., Balk, J.M., Bast, A., Koek, G.H., Haenen, G.R.M.M.

“…Cytochrome P450 2E1 (CYP2E1) expression and activity in the liver is associated with the degree of liver damage in patients with alcoholic steatohepatitis…”
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Effects of vitamin E or lipoic acid supplementation on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type II diabetes by Baumgartner, S, Mensink, R.P, Haenen, G, Bast, A, Binder, C, Bekers, O, Husche, C, Lütjohann, D, Plat, J

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Masking of antioxidant capacity by the interaction of flavonoids with protein by Arts, M.J.T.J, Haenen, G.R.M.M, Voss, H.-P, Bast, A

“…The effect of antioxidants is often executed in complex biological mixtures where various interactions may take place. Therefore, the antioxidant capacity of…”
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Rutin protects against endothelial dysfunction and induces nrf2-mediated adaptation in huvecs exposed to oxidative stress by Sthijns, M., Schiffers, P., Janssen, G., Lemmens, K., Ides, B., Vangrieken, P., Bouwman, F., Mariman, E., Pader, I., Arnér, E., Johansson, K., Bast, A., Haenen, G.

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The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model by van den Heuvel, M.G.W, Bast, A, Haenen, G.R.M.M, Ambergen, A.W, Mermans, J.F, van der Hulst, R.R.W.J

“…Summary Background A better understanding of the pathophysiology of ischaemia-reperfusion injury and a possible treatment for it, is of great importance. The…”
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Transcription factor NF-κB as a potential biomarker for oxidative stress by van den Berg, R., Haenen, G. R. M. M., van den Berg, H., Bast, A.

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Editorial: enhancing gluten digestion in the stomach – a further help to minimise unintentional ingestion? Authors’ reply by Salden, B. N., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., Masclee, A. A.

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Letter: gluten digestion in the stomach and duodenum by Aspergillus niger‐derived enzyme – things to ponder. Authors’ reply by Salden, B. N., Montserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., Masclee, A. A

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Genotoxic effects of neutrophils and hypochlorous acid by Güngör, Nejla, Knaapen, Ad M., Munnia, Armelle, Peluso, Marco, Haenen, Guido R., Chiu, Roland K., Godschalk, Roger W. L., van Schooten, Frederik J.

“…Chronic inflammation has been recognized as a contributing factor in the pathogenesis of lung cancer. In this process, reactive oxygen species released by…”
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Protectors against doxorubicin-induced cardiotoxicity: flavonoids by Bast, A, Kaiserová, H, den Hartog, G J M, Haenen, G R M M, van der Vijgh, W J F

“…Doxorubicin is a widely used anthracycline anticancer agent. Its use may cause cardiomyopathy: in fact, the development of cumulative dose-related…”
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The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor- B by Jacobs, H, Bast, A, Peters, G J, Van Der Vijgh, W J F, Haenen, G R M M

“…Despite therapeutic advances, the prognosis of patients with metastatic soft tissue sarcoma (STS) remains extremely poor. The results of a recent clinical…”
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The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB by Jacobs, H, Bast, A, Peters, G J, van der Vijgh, W J F, Haenen, G R M M

“…Background: Despite therapeutic advances, the prognosis of patients with metastatic soft tissue sarcoma (STS) remains extremely poor. The results of a recent…”
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Differences in Pharmacological Activities of the Antioxidant Flavonoid MonoHER in Humans and Mice Are Caused by Variations in Its Metabolic Profile by Jacobs, H, Koek, G H, Peters, R, Moalin, M, Tack, J, Vijgh, W J, Bast, A, Haenen, G R

“…Despite its well‐known cardiotoxicity, the anthracycline doxorubicin continues to be a widely used chemotherapeutic agent. The flavonoid…”
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A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms by Nia, A.Besarati, Van Schooten, F.J., Schilderman, P.A.E.L., De Kok, T.M.C.M., Haenen, G.R., Van Herwijnen, M.H.M., Van Agen, E., Pachen, D., Kleinjans, J.C.S.

“…We investigated the effects of smoking-induced oxidative stress in healthy volunteers (21 smokers versus 24 non-smokers) by quantifying various markers of…”
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Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups by Heijnen, C.G.M, Haenen, G.R.M.M, van Acker, F.A.A, van der Vijgh, W.J.F, Bast, A

“…It has been reported that flavonoids efficiently protect against peroxynitrite toxicity. Two pharmacophores have been identified in flavonoids, namely the…”
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