ANTIBODY RESPONSE TO EPSILON TOXIN OF CLOSTRIDIUM PERFRINGENS IN CAPTIVE ADULT SPRINGBOK ( ANTIDORCAS MARSUPIALIS ), IMPALA ( AEPYCEROS MELAMPUS ), ALPACA ( VICUGNA PACOS ), AND RED-NECKED WALLABY ( MACROPUS RUFOGRISEUS ) OVER A YEAR

Enterotoxemia is an important issue in various zoological taxa. In this study, serologic responses over a 1-yr period after vaccination with a multivalent clostridial vaccine were evaluated in 10 adult springboks ( ), 12 impalas ( ), seven alpacas ( ), and five red-necked wallabies ( ). Antibody pro...

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Bibliographic Details
Published in:	Journal of zoo and wildlife medicine Vol. 52; no. 1; p. 192
Main Authors:	Rousselet, Estelle, Tarin, Beatrice, Petit, Thierry, Blanc, Barbara, Ortiz, Katia, Haelewyn, Franck, Chenet, Baptiste, Leclerc, Antoine
Format:	Journal Article
Language:	English
Published:	United States 01-04-2021
Subjects:	Animals Animals, Zoo Antelopes - blood Antelopes - immunology Antibodies, Bacterial - blood Bacterial Toxins - immunology Bacterial Vaccines - immunology Camelids, New World - blood Camelids, New World - immunology Clostridium Infections - prevention & control Clostridium Infections - veterinary Clostridium perfringens - immunology Female Macropodidae - blood Macropodidae - immunology Male Time Factors
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Summary:	Enterotoxemia is an important issue in various zoological taxa. In this study, serologic responses over a 1-yr period after vaccination with a multivalent clostridial vaccine were evaluated in 10 adult springboks ( ), 12 impalas ( ), seven alpacas ( ), and five red-necked wallabies ( ). Antibody production to the type D epsilon toxin component of the vaccine was measured using an indirect enzyme-linked immunosorbent assay and determined as the percentage of inhibition (% inhib). Initial % inhib was (0.01-18.9)%. All animals received initial vaccination with a booster vaccine 4 weeks apart. Serum samples were collected at T0 (nonvaccinated), 15, 30, 60, 180, and 360 days postvaccination (dpv) for analysis. The vaccine induced a high antibody response that peaked at 15, 30, and 60 dpv in springboks, 30 and 60 dpv in impalas ( < 0.01), and 60 dpv in alpacas and wallabies ( < 0.01). The booster vaccine was followed by a high antibody response, which slowly decreased with time. The antibody response was significantly higher at 360 dpv than at T0 in wallabies and alpacas ( < 0.01). In impalas and springboks, it appeared that a booster every 6 mo might be required to maintain an antibody response above baseline ( < 0.01). Because no challenge studies were performed, it is unknown whether the measured humoral immune responses would have been protective. Further research is warranted to investigate protective effects of antibodies to inoculation challenge in nondomestic species.
ISSN:	1042-7260
DOI:	10.1638/2020-0016