Search Results - "Haegert, D G"

Altered naive CD4 and CD8 T cell homeostasis in patients with relapsing‐remitting multiple sclerosis: thymic versus peripheral (non‐thymic) mechanisms by Duszczyszyn, D. A., Beck, J. D., Antel, J., Bar‐Or, A., Lapierre, Y., Gadag, V., Haegert, D. G.

“…Summary We have reported previously that naive T cells from relapsing‐remitting multiple sclerosis (RRMS) patients have T cell receptor (TCR) repertoire…”
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Identical twins discordant for multiple sclerosis have a shift in their T‐cell receptor repertoires by HAEGERT, D. G., GALUTIRA, D., MURRAY, T. J., O'CONNOR, P., GADAG, V.

“…SUMMARY CD4 T‐cells have an important role in the autoimmune response in multiple sclerosis (MS). We investigate the possibility that a shift occurs in the…”
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Analysis of the threshold liability model provides new understanding of causation in autoimmune diseases by Haegert, D.G

“…Autoimmune diseases include a heterogeneous group of complex traits, the causes of which are essentially unknown. The threshold liability model is a hypothesis…”
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Complications of immunosuppression associated with weekly low dose methotrexate by Shiroky, J B, Frost, A, Skelton, J D, Haegert, D G, Newkirk, M M, Neville, C

“…Complications of immunosuppression are thought to be rare with the use of low dose pulse methotrexate (MTX) for nonneoplastic conditions. We describe 4…”
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Does a shift in the T-cell receptor repertoire precede the onset of MS? by HAEGERT, D. G, COWAN, T, MURRAY, T. J, GADAG, V, O'CONNOR, P

“…Utz et al., in a study of identical twins discordant for MS, showed that antigen-stimulated T cells from the MS twins have a major shift in their T-cell…”
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Establishing a clinic-based pancreatic cancer and periampullary tumour research registry in Quebec by Smith, A L, Bascuñana, C, Hall, A, Salman, A, Andrei, A Z, Volenik, A, Rothenmund, H, Ferland, D, Lamoussenery, D, Kamath, A S, Amre, R, Caglar, D, Gao, Z H, Haegert, D G, Kanber, Y, Michel, R P, Omeroglu-Altinel, G, Asselah, J, Bouganim, N, Kavan, P, Arena, G, Barkun, J, Chaudhury, P, Gallinger, S, Foulkes, W D, Omeroglu, A, Metrakos, P, Zogopoulos, G

“…Enrolling patients in studies of pancreatic ductal adenocarcinoma (pdac) is challenging because of the high fatality of the disease. We hypothesized that a…”
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Genetic susceptibility to multiple sclerosis by Haegert, D G, Marrosu, M G

“…Twin studies have established that susceptibility to multiple sclerosis (MS) is partly genetic. Attempts to identify the relevant genetic loci have involved…”
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HLA-DQA1 and -DQB1 associations with multiple sclerosis in Sardinia and French Canada : evidence for immunogenetically distinct patient groups by HAEGERT, D. G, MUNTONI, F, MURRU, M. R, COSTA, G, FRANCIS, G. S, MARROSU, M. G

“…We analyzed the association of HLA-DQA1 and -DQB1 alleles with multiple sclerosis (MS) in a collaborative study of 116 Sardinian and 75 French Canadian MS…”
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Multiple sclerosis and HLA class II susceptibility and resistance genes by Haegert, D G, Michaud, M, Schwab, C, Francis, G S

“…Probes to the HLA class II genes DR beta, DQ beta, and DQ alpha were used to study DNA from unrelated Caucasian multiple sclerosis (MS) patients by sequential…”
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Contribution of a single DQ beta chain residue to multiple sclerosis in French Canadians by Haegert, D G, Francis, G S

“…Putative disease susceptibility and resistance HLA class II alleles were studied in 78 French Canadian multiple sclerosis (MS) patients and 79 controls by…”
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Method to identify biases in PCR amplification of T-cell receptor variable region genes by Daniel, E S, Haegert, D G

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Phenotypic and genotypic heterogeneity of peripheral T-cell lymphoma by SMITH, J. L, HAEGERT, D. G, HODGES, E, STACEY, G. N, HOWELL, W. M, WRIGHT, D. H, JONES, D. B

“…A series of 21 phenotypically characterised T-cell lymphomas histologically defined as lymphocytic, lymphoblastic, immunoblastic, AILD type, pleomorphic,…”
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Expression of T3 and T11 determinants on human peripheral lymphocytes as analysed by the indirect antiglobulin rosetting reaction (IARR) and indirect immunofluorescence by HAEGERT, D. G

“…Whereas by indirect immunofluorescence approximately 80% of freshly isolated human peripheral blood lymphocytes bound T3 (Leu 4)-specific and T11-specific…”
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Quantitation of T-cell receptor transcripts using a wet agarose gel method by Daniel, E S, Haegert, D G

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Method of data analysis that elucidates contributions to the T-cell receptor repertoire by Daniel, E S, Gadag, V G, Haegert, D G

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Absence of strong HLA-DR/DQ-DP linkage disequilibrium in the British and French Canadian Caucasoid populations by Howell, W M, Evans, P R, Devereux, S A, Sage, D A, Smith, J L, Haegert, D G

“…HLA-DR/DQ-DP linkage disequilibrium was investigated in healthy, unrelated British (n = 150) and French Canadian (n = 67) Caucasoid subjects. HLA-DR and DQ…”
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HLA-DR beta, -DQ alpha, and -DQ beta restriction fragment length polymorphisms in multiple sclerosis by Haegert, D G, Michaud, M, Schwab, C, Tansey, C, Décary, F, Francis, G

“…Restriction fragment length polymorphism (RFLP) studies were performed on DNA from unrelated Caucasian patients with multiple sclerosis (MS) using cDNA probes…”
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PCR-SSO typing for HLA-DPB alleles by Howell, W M, Sage, D A, Haegert, D G, Evans, P R, Smith, J L

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Phagocytic peripheral blood monocytes from rabbits and humans express membrane receptors specific for IgM molecules: evidence that incubation with neuraminidase exposes cryptic IgM (Fc) receptors by Haegert, D G

“…Phagocytic human and rabbit peripheral blood monocytes, identified by their ingestion of polystyrene particles, were investigated for the presence of surface…”
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Multiple sclerosis in French Canadians: evidence for HLA class II susceptibility and resistance genes by Haegert, D G, Michaud, M, Francis, G S

“…HLA class II DRB1, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction…”
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