Search Results - "Haeger, Sarah M."

Heparan Sulfate in the Developing, Healthy, and Injured Lung by Haeger, Sarah M, Yang, Yimu, Schmidt, Eric P

“…Remarkable progress has been achieved in understanding the regulation of gene expression and protein translation, and how aberrancies in these template-driven…”
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Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus by Wang, Huan, Haeger, Sarah M, Kloxin, April M, Leinwand, Leslie A, Anseth, Kristi S

“…Fibroblasts residing in connective tissues throughout the body are responsible for extracellular matrix (ECM) homeostasis and repair. In response to tissue…”
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Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution by Yang, Yimu, Haeger, Sarah M, Suflita, Matthew A, Zhang, Fuming, Dailey, Kyrie L, Colbert, James F, Ford, Joshay A, Picon, Mario A, Stearman, Robert S, Lin, Lei, Liu, Xinyue, Han, Xiaorui, Linhardt, Robert J, Schmidt, Eric P

“…The endothelial glycocalyx is a heparan sulfate (HS)-rich endovascular structure critical to endothelial function. Accordingly, endothelial glycocalyx…”
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A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis by Colbert, James F, Ford, Joshay A, Haeger, Sarah M, Yang, Yimu, Dailey, Kyrie L, Allison, Kristen C, Neudecker, Viola, Evans, Christopher M, Richardson, Vanessa L, Brodsky, Kelley S, Faubel, Sarah, Eltzschig, Holger K, Schmidt, Eric P, Ginde, Adit A

“…Sepsis outcomes are heavily dependent on the development of septic organ injury, but no interventions exist to interrupt or reverse this process. microRNA-223…”
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Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding by Zhang, Yanlin, Haeger, Sarah M, Yang, Yimu, Dailey, Kyrie L, Ford, Joshay A, Schmidt, Eric P

“…ABSTRACTExtracellular histones are cationic damage-associated molecular pattern molecules capable of directly inducing cellular injury via charge-mediated…”
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Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma by MALKOSKI, Stephen P, HAEGER, Sarah M, IJICHI, Hideaki, FRANKLIN, Wilbur, WANG, Xiao-Jing, CLEAVER, Timothy G, RODRIGUEZ, Karen J, LI, Howard, LU, Shi-Long, FESER, William J, BARON, Anna E, MERRICK, Daniel, LIGHTHALL, Jessyka G

“…Lung adenocarcinoma and lung squamous cell carcinoma (SCC) are the most common non-small cell lung cancer (NSCLC) subtypes. This study was designed to…”
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More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series) by Oshima, Kaori, Haeger, Sarah M., Hippensteel, Joseph A., Herson, Paco S., Schmidt, Eric P.

“…Advances in tissue fixation and imaging techniques have yielded increasing appreciation for the glycosaminoglycan-rich endothelial glycocalyx and its in vivo…”
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Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions by Zhang, Xing, Han, Xiaorui, Xia, Ke, Xu, Yongmei, Yang, Yimu, Oshima, Kaori, Haeger, Sarah M., Perez, Mario J., McMurtry, Sarah A., Hippensteel, Joseph A., Ford, Joshay A., Herson, Paco S., Liu, Jian, Schmidt, Eric P., Linhardt, Robert J.

“…Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis,…”
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Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury by Haeger, Sarah M, Liu, Xinyue, Han, Xiaorui, McNeil, J Brennan, Oshima, Kaori, McMurtry, Sarah A, Yang, Yimu, Ouyang, Yilan, Zhang, Fuming, Nozik-Grayck, Eva, Zemans, Rachel L, Tuder, Rubin M, Bastarache, Julie A, Linhardt, Robert J, Schmidt, Eric P

“…The lung epithelial glycocalyx is a carbohydrate-enriched layer lining the pulmonary epithelial surface. Although epithelial glycocalyx visualization has been…”
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Hepcidin Removal during Continuous Renal Replacement Therapy by Colbert, James F, Griffin, Benjamin R, Rolloff, Kristy, Erzen, Christopher L, Haeger, Sarah M, Altmann, Chris, Okamura, Kayo, Campbell, Ruth, Teitelbaum, Isaac, Faubel, Sarah

“…Patients with acute kidney injury (AKI) or end stage kidney disease (ESKD) may require continuous renal replacement therapy (CRRT) as a supportive…”
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Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses by Oshima, Kaori, Han, Xiaorui, Ouyang, Yilan, El Masri, Rana, Yang, Yimu, Haeger, Sarah M, McMurtry, Sarah A, Lane, Trevor C, Davizon-Castillo, Pavel, Zhang, Fuming, Yue, Xinping, Vivès, Romain R, Linhardt, Robert J, Schmidt, Eric P

“…Sepsis patients are at increased risk for hospital-acquired pulmonary infections, potentially due to postseptic immunosuppression known as the compensatory…”
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Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors by Haeger, S M, Thompson, J J, Kalra, S, Cleaver, T G, Merrick, D, Wang, X-J, Malkoski, S P

“…Non-small-cell lung cancer (NSCLC) is a common malignancy with a poor prognosis. Despite progress targeting oncogenic drivers, there are no therapies targeting…”
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Epidermal Smad4 Deletion Results in Aberrant Wound Healing by Owens, Philip, Engelking, Erin, Han, Gangwen, Haeger, Sarah M, Wang, Xiao-Jing

“…In the present study, we assessed the role of Smad4, a component of the transforming growth factor-β signaling pathway, in cutaneous wound repair…”
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Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome by Rizzo, Alicia N, Haeger, Sarah M, Oshima, Kaori, Yang, Yimu, Wallbank, Alison M, Jin, Ying, Lettau, Marie, McCaig, Lynda A, Wickersham, Nancy E, McNeil, J Brennan, Zakharevich, Igor, McMurtry, Sarah A, Langouët-Astrié, Christophe J, Kopf, Katrina W, Voelker, Dennis R, Hansen, Kirk C, Shaver, Ciara M, Kerchberger, V Eric, Peterson, Ryan A, Kuebler, Wolfgang M, Ochs, Matthias, Veldhuizen, Ruud Aw, Smith, Bradford J, Ware, Lorraine B, Bastarache, Julie A, Schmidt, Eric P

“…Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic…”
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Role of PTEN in basal cell derived lung carcinogenesis by Malkoski, Stephen P., Cleaver, Timothy G., Thompson, Joshua J., Sutton, Whitney P., Haeger, Sarah M., Rodriguez, Karen J., Lu, Shi-Long, Merrick, Daniel, Wang, Xiao-Jing

“…Lung adenocarcinoma (AdC) and lung squamous cell carcinoma (SCC) are the most common non‐small cell lung cancer (NSCLC) subtypes, however, most genetic mouse…”
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Post‐septic Down‐regulation of Sulfatase‐1 Suppresses Pulmonary Endothelial ICAM‐1 Expression by Oshima, Kaori, Yang, Yimu, Haeger, Sarah M., Lane, Trevor C., Linhardt, Robert J., Schmidt, Eric P.

“…Rationale Post‐septic compensatory anti‐inflammatory syndrome (CARS) is a state of immunoparalysis that leaves patients susceptible to secondary infections…”
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Transforming Growth Factor-β Receptor Type II Deletion Increases the Multiplicity and Growth of K-ras–induced Lung Cancers by Cleaver, Timothy G., Haeger, Sarah M., Rodriguez, Karen J., Lighthall, Jessyka G., Lu, Shi-Long, Merrick, Daniel, Wang, Xiao-Jing, Malkoski, Stephen P.

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