Search Results - "Haegele, K D"

Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans by Dow, J, Piriou, F, Wolf, E, Dulery, B D, Haegele, K D

“…Mofegiline or MDL 72,974A ((E)-4-fluoro-beta-fluoromethylene benzene butanamine hydrochloride) is a selective enzyme-activated irreversible inhibitor of…”
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Analysis of 2-difluoromethyl- dl-ornithine in human plasma, cerebrospinal fluid and urine by cation-exchange high-performance liquid chromatography by Huebert, N.D., Schwartz, J.-J., Haegele, K.D.

“…An analytical method has been developed based on cation-exchange liquid chromatography for the measurement of 2-difluoromethyl- dl-ornithine (DFMO) in human…”
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Comparative aspects on the bioaccumulation, metabolism and toxicity with PCBs by Borlakoglu, J T, Haegele, K D

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Cardioselectivity of alpha-tocopherol analogues, with free radical scavenger activity, in the rat by Dow, J, Petty, M A, Grisar, J M, Wagner, E R, Haegele, K D

“…MDL74270 (6-acetyloxy-3,4-dihydro-N,N,N,2,5,7, 8-heptamethyl-2H-1-benzopyran-2-ethanaminium, 4-methylbenzenesulfonate) is a quaternary amine analogue of…”
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Cerebrospinal fluid parameters in healthy volunteers during serial lumbar punctures by Ben Menachem, E, Persson, L, Schechter, P J, Haegele, K D, Huebert, N, Hardenberg, J

“…Lumbar punctures were performed on four occasions over a 5-day period (8:30 a.m. on days 1, 3, and 5; 2:30 p.m. on day 2) on 10 normal volunteers (five of each…”
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Metabolism and pharmacokinetics of the cardiotonic agent piroximone and of its major metabolite in dog by Berg-Candolfi, M, Dulery, B, Jehl, F, Haegele, K D

“…1. Piroximone was administered orally (p.o.) and intravenously (i.v.) to male Beagle dog. In vitro, piroximone was incubated with dog liver microsomes. 2…”
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The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients by Ben‐Menachem, E, Persson, LI, Schechter, PJ, Haegele, KD, Huebert, N, Hardenberg, J, Dahlgren, L, Mumford, JP

“…1. Vigabatrin, 50 mg kg‐1, was administered orally as add‐on therapy to 11 patients with drug‐resistant complex partial epilepsy as a single dose, then once…”
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Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system by Carroll, D. I, Dzidic, I, Stillwell, R. N, Haegele, K. D, Horning, E. C

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Kinetics of the enantiomers of vigabatrin after an oral dose of the racemate or the active S-enantiomer by Haegele, K D, Schechter, P J

“…Six healthy men received single oral doses of 1500 mg of vigabatrin [(R,S)-gamma-vinyl-GABA] and 750 mg of S(+)-gamma-vinyl-GABA on two occasions…”
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Pharmacokinetics of vigabatrin: implications of creatinine clearance by Haegele, K D, Huebert, N D, Ebel, M, Tell, G P, Schechter, P J

“…The pharmacokinetics of both enantiomers of vigabatrin after a single oral dose in healthy young subjects (mean creatinine clearance 120 ml/min) were compared…”
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Review: Normal and abnormal central nervous system GABA metabolism in childhood by Jaeken, J., Casaer, P., Haegele, K. D., Schechter, P. J.

“…Summary The metabolism and function of central nervous system GABA is briefly reviewed. Hereditary disorders of the GABA metabolism presenting in childhood are…”
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2-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid by Haegele, K D, Schwartz, J J, Schoun, J, Schmitt, A H, Schechter, P J

“…2-Pyrrolidinone, the lactam of gamma-aminobutyric acid (GABA), is identified as the major constituent of total GABA in human CSF. Structural elucidation was…”
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Treatment of human late stage gambiense trypanosomiasis with alpha-difluoromethylornithine (eflornithine): efficacy and tolerance in 14 cases in Côte d'Ivoire by Doua, F, Boa, F Y, Schechter, P J, Miézan, T W, Diai, D, Sanon, S R, De Raadt, P, Haegele, K D, Sjoerdsma, A, Konian, K

“…alpha-Difluoromethylornithine (DFMO; eflornithine), an inhibitor of polyamine biosynthesis, was used to treat 14 patients with late stage gambiense sleeping…”
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Selectivity of MDL 72,974A for MAO-B inhibition based on substrate and metabolite concentrations in plasma by Huebert, N D, Schwach, V, Hinze, C, Haegele, K D

“…Plasma concentrations of 3,4-dihydroxyphenylethylglycol (DOPEG), noradrenaline (NA), adrenaline (A), 3,4-dihydroxyphenylalanine (DOPA),…”
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Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy by Menachem, E B, Persson, L I, Schechter, P J, Haegele, K D, Huebert, N, Hardenberg, J, Dahlgren, L, Mumford, J P

“…Vigabatrin, as a single oral dose of 50 mg/kg, was administered to 11 patients with drug-refractory complex partial epilepsy. Serial lumbar punctures were…”
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Kinetics and metabolism of p-tyramine during monoamine oxidase inhibition by mofegiline by Huebert, N D, Dulery, B D, Schoun, J, Schwach, V, Hinze, C, Haegele, K D

“…The effects of monoamine oxidase B (MAO-B) inhibition by mofegiline on the pharmacokinetics of p-tyramine and its major metabolite, p-hydroxyphenylacetic acid,…”
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Analysis of ( R)-4-oxo-5-phosphononorvaline (MDL 100,453) in rat plasma and brain dialysate using liquid chromatography after derivatization with 6-aminoquinolyl- N-hydroxysuccinimidyl carbamate by Cornelius, Kenneth E., Fadayel, Gina M., Baron, Bruce M., Schmidt, Christopher J., Haegele, Klaus D., Chen, Teng-Man

“…A liquid chromatographic (LC) method with precolumn derivatization and fluorescence detection has been developed for the quantitation of (…”
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Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo:: Importance of drug ionisation in the in vitro prediction of in vivo absorption by Boisset, Michel, Botham, Roger P., Haegele, Klaus D., Lenfant, Bernard, Pachot, Jean I.

“…The aims of this study were (i) to compare the absorption of three closely related inhibitors of angiotensin II, RU60018, RU60079 and HR720, in various in…”
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Determination of an acetylcholinesterase inhibitor, MDL 73745, in dog plasma and urine by combined gas chromatography/negative ion chemical ionization mass spectrometry by Dulery, B D, Le Henanf, N, Dow, J, Haegele, K D

“…A highly sensitive and specific assay has been developed for the determination of MDL 73745 [2,2,2-trifluoro-1-(3-trimethylsilyl-phenyl) ethanone] (I) and the…”
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GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary by Loeffler, J P, Demeneix, B A, Pittius, C W, Kley, N, Haegele, K D, Höllt, V

“…The GABAergic regulation of proopiomelanocortin messenger RNA (POMC mRNA) levels in rat pituitary was investigated using molecular hybridization of DNA…”
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