Search Results - "Hae Kim, Jee"

Activin A more prominently regulates muscle mass in primates than does GDF8 by Latres, Esther, Mastaitis, Jason, Fury, Wen, Miloscio, Lawrence, Trejos, Jesus, Pangilinan, Jeffrey, Okamoto, Haruka, Cavino, Katie, Na, Erqian, Papatheodorou, Angelos, Willer, Tobias, Bai, Yu, Hae Kim, Jee, Rafique, Ashique, Jaspers, Stephen, Stitt, Trevor, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

“…Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent…”
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Over-Expression of p190RhoGEF Regulates the Formation of Atherosclerotic Plaques in the Aorta of ApoE−/− Mice via Macrophage Polarization by Choi, So-Yeon, Lee, Eun-Bi, Kim, Jee-Hae, Lee, Jong Ran

“…The RhoA-specific guanine nucleotide exchange factor p190RhoGEF has been implicated in the control of cell morphology, focal adhesion formation, and cell…”
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Over‐expression of p190RhoGEF enhances B‐cell activation and germinal center formation in T‐cell‐dependent humoral immune responses by Jeong, Ji Hye, Ha, Yun Jung, Choi, So‐Yeon, Kim, Jee‐Hae, Yun, Yungdae, Lee, Jong Ran

“…Previously, we reported induced expression of the p190 Rho guanine nucleotide exchange factor (p190RhoGEF, ARHGEF28) following CD40 stimulation of B cells…”
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Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development by Zhao, Haotian, Ayrault, Olivier, Zindy, Frederique, Kim, Jee-Hae, Roussel, Martine F

“…Bone morphogenic proteins 2 and 4 (BMP2 and BMP4) inhibit proliferation and induce differentiation of cerebellar granule neuron progenitors (GNPs) and primary…”
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IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation by Allinne, Jeanne, Scott, George, Lim, Wei Keat, Birchard, Dylan, Erjefält, Jonas S., Sandén, Caroline, Ben, Li-Hong, Agrawal, Amit, Kaur, Navneet, Kim, Jee Hae, Kamat, Vishal, Fury, Wen, Huang, Tammy, Stahl, Neil, Yancopoulos, George D., Murphy, Andrew J., Sleeman, Matthew A., Orengo, Jamie M.

“…Severe inflammatory airway diseases are associated with inflammation that does not resolve, leading to structural changes and an overall environment primed for…”
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Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys by Okamoto, Haruka, Kim, Jinrang, Aglione, JohnPaul, Lee, Joseph, Cavino, Katie, Na, Erqian, Rafique, Ashique, Kim, Jee Hae, Harp, Joyce, Valenzuela, David M, Yancopoulos, George D, Murphy, Andrew J, Gromada, Jesper

“…Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic glucose production in settings of hyperglycemia where glucagon…”
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Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency by Altarejos, Judith Y, Pangilinan, Jeffrey, Podgrabinska, Simona, Akinci, Baris, Foss-Freitas, Maria, Neidert, Adam H, Ray, Yonaton, Zheng, Wenjun, Kim, Steven, Kamat, Vishal, Huang, Meilin, Min, Soo, Mastaitis, Jason, Dominguez-Gutierrez, Giselle, Kim, Jee-Hae, Stevis, Panayiotis, Huang, Tammy, Zambrowicz, Brian, Olson, William C, Godin, Stephen, Bradley, Elizabeth, Gewitz, Andrew D, Baker, Mark, Hench, Rita, Davenport, Matthew S, Chenevert, Thomas L, DiPaola, Frank, Yancopoulos, George D, Murphy, Andrew J, Herman, Gary A, Musser, Bret J, Dansky, Hayes, Harp, Joyce, Gromada, Jesper, Sleeman, Mark W, Oral, Elif A, Olenchock, Benjamin A

“…Deficiency in the adipose-derived hormone leptin or leptin receptor signaling causes class 3 obesity in individuals with genetic loss-of-function mutations in…”
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WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation by Anne, Sandrine L, Govek, Eve-Ellen, Ayrault, Olivier, Kim, Jee Hae, Zhu, Xiaodong, Murphy, David A, Van Aelst, Linda, Roussel, Martine F, Hatten, Mary E

“…During normal cerebellar development, the remarkable expansion of granule cell progenitors (GCPs) generates a population of granule neurons that outnumbers the…”
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Clinical Validity of Next-Generation Sequencing Multi-Gene Panel Testing for Detecting Pathogenic Variants in Patients With Hereditary Breast-Ovarian Cancer Syndrome by Yoo, Jaeeun, Lee, Gun Dong, Kim, Jee Hae, Lee, Seung Nam, Chae, Hyojin, Han, Eunhee, Kim, Yonggoo, Kim, Myungshin

“…Hereditary breast and ovarian cancer syndrome (HBOC) is caused by pathogenic variants in and other cancer-related genes. We analyzed variants in gene and other…”
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Role of Unc51.1 and its binding partners in CNS axon outgrowth by Tomoda, Toshifumi, Kim, Jee Hae, Zhan, Caixin, Hatten, Mary E

“…Previous studies showed that the serine/threonine kinase Unc51.1 is one of the earliest genes in neuronal differentiation and is required for granule cell axon…”
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The Role of Synaptic GTPase-Activating Protein in Neuronal Development and Synaptic Plasticity by Kim, Jee Hae, Lee, Hey-Kyoung, Takamiya, Kogo, Huganir, Richard L

“…Synaptic GTPase-activating protein (SynGAP) is a neuronal RasGAP (Ras GTPase-activating protein) that is selectively expressed in brain and highly enriched at…”
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ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S] by Gusarova, Viktoria, Alexa, Corey A., Wang, Yan, Rafique, Ashique, Kim, Jee Hae, Buckler, David, Mintah, Ivory J., Shihanian, Lisa M., Cohen, Jonathan C., Hobbs, Helen H., Xin, Yurong, Valenzuela, David M., Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

“…Angiopoietin-like protein 3 (ANGPTL3) is a circulating protein synthesized exclusively in the liver that inhibits LPL and endothelial lipase (EL), enzymes that…”
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Organization and regulation of proteins at synapses by Kim, Jee Hae, Huganir, Richard L

“…The organization and regulation of synaptic connections in the mammalian nervous system entail complicated and co-ordinated molecular and cellular processes…”
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ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys by Gusarova, Viktoria, Alexa, Corey A, Wang, Yan, Rafique, Ashique, Kim, Jee Hae, Buckler, David, Mintah, Ivory J, Shihanian, Lisa M, Cohen, Jonathan C, Hobbs, Helen H, Xin, Yurong, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gromada, Jesper

“…Angiopoietin-like protein 3 (ANGPTL3) is a circulating protein synthesized exclusively in the liver that inhibits LPL and endothelial lipase (EL), enzymes that…”
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Structural insights into CXCR4 modulation and oligomerization by Saotome, Kei, McGoldrick, Luke L, Ho, Jo-Hao, Ramlall, Trudy F, Shah, Sweta, Moore, Michael J, Kim, Jee Hae, Leidich, Raymond, Olson, William C, Franklin, Matthew C

“…Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates diverse cellular processes. Previously reported crystal structures of CXCR4…”
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Over‐expression of p190Rho GEF enhances B‐cell activation and germinal center formation in T‐cell‐dependent humoral immune responses by Jeong, Ji Hye, Ha, Yun Jung, Choi, So‐Yeon, Kim, Jee‐Hae, Yun, Yungdae, Lee, Jong Ran

“…Previously, we reported induced expression of the p190 Rho guanine nucleotide exchange factor ( p190Rho GEF , ARHGEF 28 ) following CD 40 stimulation of B…”
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SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family by Kim, Jee Hae, Liao, Dezhi, Lau, Lit-Fui, Huganir, Richard L

“…The PSD-95/SAP90 family of proteins has recently been implicated in the organization of synaptic structure. Here, we describe the isolation of a novel…”
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WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation: e81769 by Anne, Sandrine L, Govek, Eve-Ellen, Ayrault, Olivier, Kim, Jee Hae, Zhu, Xiaodong, Murphy, David A, Aelst, Linda Van, Roussel, Martine F, Hatten, Mary E

“…During normal cerebellar development, the remarkable expansion of granule cell progenitors (GCPs) generates a population of granule neurons that outnumbers the…”
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Organization and regulation of proteins at synapses by Kim, Jee Hae, Huganir, Richard L

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The role of SynGAP, a novel synaptic RasGTPase -activating protein, in neuronal development and synaptic plasticity by Kim, Jee Hae

“…Proper organization of synapses in the mammalian nervous system is critical for efficient transmission of signals between neurons. In the adult brain,…”
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