Search Results - "Hadži, San"

Crystal Structure of de Novo Designed Coiled-Coil Protein Origami Triangle by Satler, Tadej, Hadži, San, Jerala, Roman

“…Coiled-coil protein origami (CCPO) uses modular coiled-coil building blocks and topological principles to design polyhedral structures distinct from those of…”
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Thermodynamic Origin of the Linear Pressure Dependence of DNA Thermal Stability by Lah, Jurij, Hadži, San

“…High pressure affects the structure and function of DNA and is a key parameter for studying the origin and physical limits of life. Different types of DNA…”
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Structural Basis of Epitope Recognition by Heavy-Chain Camelid Antibodies by Zavrtanik, Uroš, Lukan, Junoš, Loris, Remy, Lah, Jurij, Hadži, San

“…Truncated versions of heavy-chain antibodies (HCAbs) from camelids, also termed nanobodies, comprise only one-tenth the mass of conventional antibodies, yet…”
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Estimation of Peptide Helicity from Circular Dichroism Using the Ensemble Model by Zavrtanik, Uroš, Lah, Jurij, Hadži, San

“…An established method for the quantitation of the helix content in peptides using circular dichroism (CD) relies on the linear spectroscopic model. This model…”
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Conditional Cooperativity in DNA Minor-Groove Recognition by Oligopeptides by Lah, Jurij, Hadži, San

“…The recognition of specific DNA sequences in processes such as transcription is associated with a cooperative binding of proteins. Some transcription…”
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The sequence–ensemble relationship in fuzzy protein complexes by Hadži, San, Loris, Remy, Lah, Jurij

“…Intrinsically disordered proteins (IDPs) interact with globular proteins through a variety of mechanisms, resulting in the structurally heterogeneous ensembles…”
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Aggregation Time Machine: A Platform for the Prediction and Optimization of Long-Term Antibody Stability Using Short-Term Kinetic Analysis by Bunc, Marko, Hadži, San, Graf, Christian, Bončina, Matjaž, Lah, Jurij

“…Monoclonal antibodies are the fastest growing class of therapeutics. However, aggregation limits their shelf life and can lead to adverse immune responses…”
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A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT by Talavera, Ariel, Tamman, Hedvig, Ainelo, Andres, Konijnenberg, Albert, Hadži, San, Sobott, Frank, Garcia-Pino, Abel, Hõrak, Rita, Loris, Remy

“…Bacterial toxin-antitoxin (TA) modules are tightly regulated to maintain growth in favorable conditions or growth arrest during stress. A typical regulatory…”
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Leucine Motifs Stabilize Residual Helical Structure in Disordered Proteins by Zavrtanik, Uroš, Medved, Tadej, Purič, Samo, Vranken, Wim, Lah, Jurij, Hadži, San

“…[Display omitted] •helical binding motifs mediate protein interactions and fold into α-helix upon binding.•database of 65 helical binding motifs and their…”
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The Thermodynamic Basis of the Fuzzy Interaction of an Intrinsically Disordered Protein by Hadži, San, Mernik, Andrej, Podlipnik, Črtomir, Loris, Remy, Lah, Jurij

“…Many intrinsically disordered proteins (IDP) that fold upon binding retain conformational heterogeneity in IDP‐target complexes. The thermodynamics of such…”
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Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae by Hadži, San, Živič, Zala, Kovačič, Matic, Zavrtanik, Uroš, Haesaerts, Sarah, Charlier, Daniel, Plavec, Janez, Volkov, Alexander N., Lah, Jurij, Loris, Remy

“…Disordered protein sequences can exhibit different binding modes, ranging from well-ordered folding-upon-binding to highly dynamic fuzzy binding. The primary…”
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Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism by Hadži, San, Garcia-Pino, Abel, Haesaerts, Sarah, Jurenas, Dukas, Gerdes, Kenn, Lah, Jurij, Loris, Remy

“…Toxin-antitoxin (TA) modules are small operons involved in bacterial stress response and persistence. higBA operons form a family of TA modules with an…”
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G-Quadruplex Stability from DSC Measurements by Hadži, San, Bončina, Matjaž, Lah, Jurij

“…Guanine-rich DNA oligonucleotides can adopt G-quadruplex (G4) structures in the presence of specific cations. Folding and unfolding of G4 can be characterized…”
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Structural polymorphism of coiled‐coils from the stalk domain of SARS‐CoV‐2 spike protein by Živič, Zala, Strmšek, Žiga, Novinec, Marko, Lah, Jurij, Hadži, San

“…Spike trimer plays a key role in SARS‐CoV‐2 infection and vaccine development. It consists of a globular head and a flexible stalk domain that anchors the…”
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A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures by Majerle, Andreja, Hadži, San, Aupič, Jana, Satler, Tadej, Lapenta, Fabio, Strmšek, Žiga, Lah, Jurij, Loris, Remy, Jerala, Roman

“…Coiled-coil (CC) dimers are widely used in protein design because of their modularity and well-understood sequence–structure relationship. In CC protein…”
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Energetic Basis of AGCGA‐Rich DNA Folding into a Tetrahelical Structure by Hadži, San, Kocman, Vojč, Oblak, Domen, Plavec, Janez, Lah, Jurij

“…It was recently discovered that, besides well‐known G‐quadruplexes and i‐motifs, DNA may adopt another type of noncanonical structure called…”
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Unraveling the Thermodynamics of Ultra-tight Binding of Intrinsically Disordered Proteins by Zavrtanik, Uroš, Hadži, San, Lah, Jurij

“…Protein interactions mediated by the intrinsically disordered proteins (IDPs) are generally associated with lower affinities compared to those between globular…”
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Structural basis of DNA binding by YdaT, a functional equivalent of the CII repressor in the cryptic prophage CP‐933P from Escherichia coli O157:H7 by Prolič-Kalinšek, Maruša, Volkov, Alexander N., Hadži, San, Van Dyck, Jeroen, Bervoets, Indra, Charlier, Daniel, Loris, Remy

“…YdaT is a functional equivalent of the CII repressor in certain lambdoid phages and prophages. YdaT from the cryptic prophage CP‐933P in the genome of…”
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Author Correction: Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae by Hadži, San, Živič, Zala, Kovačič, Matic, Zavrtanik, Uroš, Haesaerts, Sarah, Charlier, Daniel, Plavec, Janez, Volkov, Alexander N., Lah, Jurij, Loris, Remy

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Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space by Oblak, Domen, Hadži, San, Podlipnik, Črtomir, Lah, Jurij

“…The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is…”
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