Search Results - "Hadwiger, Gayla"

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells by Di Martino, Orsola, Ferris, Margaret A, Hadwiger, Gayla, Sarkar, Soyi, Vu, Anh, Menéndez-Gutiérrez, María P, Ricote, Mercedes, Welch, John S

“…RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the…”
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Endogenous and combination retinoids are active in myelomonocytic leukemias by Di Martino, Orsola, Niu, Haixia, Hadwiger, Gayla, Kuusanmaki, Heikki, Ferris, Margaret A, Vu, Anh, Beales, Jeremy, Wagner, Carl, Menéndez-Gutiérrez, María P, Ricote, Mercedes, Heckman, Caroline, Welch, John S

“…Retinoid therapy transformed response and survival outcomes in acute promyelocytic leukemia (APL), but has demonstrated only modest activity in non-APL forms…”
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A monoclonal antibody toolkit for C. elegans by Hadwiger, Gayla, Dour, Scott, Arur, Swathi, Fox, Paul, Nonet, Michael L

“…Antibodies are critical tools in many avenues of biological research. Though antibodies can be produced in the research laboratory setting, most research labs…”
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Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density by Gracheva, Elena O., Hadwiger, Gayla, Nonet, Michael L., Richmond, Janet E.

“…Rim is a multi-domain, active zone protein that regulates exocytosis and is implicated in vesicle priming and presynaptic plasticity. We recently demonstrated…”
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Defects in synaptic vesicle docking in unc-18 mutants by Jorgensen, Erik M, Weimer, Robby M, Richmond, Janet E, Davis, Warren S, Hadwiger, Gayla, Nonet, Michael L

“…Sec1-related proteins function in most, if not all, membrane trafficking pathways in eukaryotic cells. The Sec1-related protein required in neurons for…”
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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans by Gracheva, Elena O, Burdina, Anna O, Holgado, Andrea M, Berthelot-Grosjean, Martine, Ackley, Brian D, Hadwiger, Gayla, Nonet, Michael L, Weimer, Robby M, Richmond, Janet E

“…Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and…”
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A post-docking role for active zone protein Rim by Nonet, Michael L, Koushika, Sandhya P, Richmond, Janet E, Hadwiger, Gayla, Weimer, Robby M, Jorgensen, Erik M

“…Rim1 was previously identified as a Rab3 effector localized to the presynaptic active zone in vertebrates. Here we demonstrate that C. elegans unc-10 mutants…”
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Endogenous Retinoid X Receptor Ligands Act As Tumor Suppressors in MLL-AF9 Mouse Leukemia by Di Martino, Orsola, Ferris, Margaret Y, Gayla, Hadwiger, Niu, Haixia, Welch, John S.

“…Retinoid therapy transformed response and survival outcomes in acute promyelocytic leukemia (APL), but has demonstrated only modest activity in non-APL forms…”
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Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells by di Martino, Orsola, Niu, Haixia, Hadwiger, Gayla, Ferris, Margaret A., Welch, John S.

“…The orphan nuclear receptor Nur77 is an immediate-early response gene that based on tissue and cell context is implicated in a plethora of cellular processes,…”
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Pathways of retinoid synthesis in mouse macrophages and bone marrow cells by Niu, Haixia, Hadwiger, Gayla, Fujiwara, Hideji, Welch, John S.

“…Primary hematopoietic cells express Aldh3b1 and Aldh1a1, enzymes, which synthesize ATRA from vitamin A, yet do not synthesize intracellular ATRA in vivo. In…”
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Pathways of Retinoid Synthesis in Mouse Bone Marrow-Derived Macrophages and Hematopoietic Progenitors by Niu, Haixia, Hadwiger, Gayla, Fujiwara, Hideji, Welch, John S.

“…Introduction: Retinoid receptors are nuclear hormone receptors which are dynamically regulated during terminal myeloid maturation. Retinoic acid receptor α…”
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Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans by Mahoney, Timothy R, Liu, Qiang, Itoh, Takashi, Luo, Shuo, Hadwiger, Gayla, Vincent, Rose, Wang, Zhao-Wen, Fukuda, Mitsunori, Nonet, Michael L

“…Rab small GTPases are involved in the transport of vesicles between different membranous organelles. RAB-3 is an exocytic Rab that plays a modulatory role in…”
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Smc3 is required for mouse embryonic and adult hematopoiesis by Wang, Tianjiao, Glover, Brandi, Hadwiger, Gayla, Miller, Christopher A., di Martino, Orsola, Welch, John S.

“…SMC3 encodes a subunit of the cohesin complex that has canonical roles in regulating sister chromatids segregation during mitosis and meiosis. Recurrent…”
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rpm-1, A Conserved Neuronal Gene that Regulates Targeting and Synaptogenesis in C. elegans by Schaefer, Anneliese M., Hadwiger, Gayla D., Nonet, Michael L.

“…Little is known of mechanisms regulating presynaptic differentiation. We identified rpm-1 in a screen for mutants with defects in patterning of a presynaptic…”
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Redundant Localization Mechanisms of RIM and ELKS in Caenorhabditis elegans by Deken, Scott L, Vincent, Rose, Hadwiger, Gayla, Liu, Qiang, Wang, Zhao-Wen, Nonet, Michael L

“…Active zone proteins play a fundamental role in regulating neurotransmitter release and defining release sites. The functional roles of active zone components…”
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