Search Results - "Hadsell, D. L"

Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis by Kaplan-Lefko, P J, Sutherland, B W, Evangelou, A I, Hadsell, D L, Barrios, R J, Foster, B A, DeMayo, F, Greenberg, N M

“…The insulin-like growth factor-1 (IGF-1) signaling axis is important for cell growth, differentiation and survival and increased serum IGF is a risk factor for…”
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Developmental and Hormonal Signals Dramatically Alter the Localization and Abundance of Insulin Receptor Substrate Proteins in the Mammary Gland by Lee, A. V, Zhang, P, Ivanova, M, Bonnette, S, Oesterreich, S, Rosen, J. M, Grimm, S, Hovey, R. C, Vonderhaar, B. K, Kahn, C. R, Torres, D, George, J, Mohsin, S, Allred, D. C, Hadsell, D. L

“…Insulin receptor substrates (IRS) are central integrators of hormone, cytokine, and growth factor signaling. IRS proteins can be phosphorylated by a number of…”
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Genetic manipulation of the IGF-I axis to regulate mammary gland development and function by Hadsell, D L, Bonnette, S G, Lee, A V

“…Insulin-like growth factor I (IGF-I) is known to regulate mammary gland development. This regulation occurs through effects on both cell cycle progression and…”
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Technical note: assessing the functional capacity of mitochondria isolated from lactating mammary tissue: choose your chelating agent wisely by Hadsell, D L, George, J, Abraham, P A, Collier, R J, Lambert, B D

“…Previous work has indicated that respiratory activity of mitochondrial preparations prepared from lactating mammary tissue is often much lower than that of…”
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Milk glucosidase activity enables suckled pup starch digestion by Nichols, B. L., Diaz-Sotomayor, M., Avery, S. E., Chacko, S. K., Hadsell, D. L., Baker, S. S., Hamaker, B. R., Yan, L. K., Lin, H. M., Quezada-Calvillo, R.

“…ᅟ Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and…”
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Lactation Biology Symposium: circadian clocks and photoperiod in mammary gland development and lactation by Hadsell, D L

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LACTATION BIOLOGY SYMPOSIUM: Circadian clocks and photoperiod in mammary gland development and lactation1 by Hadsell, D. L.

“…The Lactation Biology Symposium on "Circadian Clocks and Photoperiod in Mammary Gland Development and Lactation" was held at the Joint Annual Meeting of the…”
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Milk yield differences between 1× and 4× milking are associated with changes in mammary mitochondrial number and milk protein gene expression, but not mammary cell apoptosis or SOCS gene expression by Alex, A P, Collier, J L, Hadsell, D L, Collier, R J

“…Milking frequency is known to affect milk production and lactation persistence in dairy cows. Despite this, the mechanisms underlying this effect are only…”
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Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis by HADSELL, D. L, MURPHY, K. L, BONNETTE, S. G, REECE, N, LAUCIRICA, R, ROSEN, J. M

“…Mammary tumorigenesis was analysed in transgenic mice which overexpress des(1-3)hIGF-I (WAP-DES) and/or a mutant form of p53 (p53172R-H). Nonlactating,…”
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IGF and insulin action in the mammary gland: lessons from transgenic and knockout models by Hadsell, D L, Bonnette, S G

“…Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact…”
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Effects of dietary insulin-like growth factor I on growth and insulin-like growth factor receptors in neonatal calf intestine by Baumrucker, C. R, Hadsell, D. L, Blum, J. W

“…Colostrum is rich in IGF-I and IGF-II, and the dietary effects of recombinant human (rh)IGF-I on the newborn are of interest. The objective of this study was…”
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In silico QTL mapping of maternal nurturing ability with the mouse diversity panel by Hadsell, D L, Wei, J, Olea, W, Hadsell, L A, Renwick, A, Thomson, P C, Shariflou, M, Williamson, P

“…Significant variation exists for maternal nurturing ability in inbred mice. Although classical mapping approaches have identified quantitative trait loci (QTL)…”
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Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice by Lee, A V, Taylor, S T, Greenall, J, Mills, J D, Tonge, D W, Zhang, P, George, J, Fiorotto, M L, Hadsell, D L

“…The detection of IGF-IR signaling in animal models has important implications for determining the role of this receptor in normal physiology and tumor growth…”
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Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows by Vega, J.R. (The Pennsylvania State University, University Park), Gibson, C.A, Skaar, T.C, Hadsell, D.L, Baumrucker, C.R

“…Concentrations of IGF-I and IGF-II, and IGF binding proteins (IGFBP) in serum and mammary gland secretions were surveyed during the dry period and early…”
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Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups by Burrin, D G, Fiorotto, M L, Hadsell, D L

“…We tested the hypothesis that chronic ingestion of increased concentrations of milk-borne des(1-3) human insulin-like growth factor-I (hIGF-I) stimulates…”
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Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds by Bonnette, S G, Hadsell, D L

“…IGF-I mediates mammary ductal development through stimulation of terminal end bud (TEB) development; however, no published data exist on the mechanism through…”
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Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase by Hadsell, D L, Baumrucker, C R, Kensinger, R S

“…The objectives of these studies were to determine if the concentration of insulin-like growth factor-I (IGF-I) in mammary colostrum secretions could be altered…”
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Estrogen-mediated down-regulation of E-cadherin in breast cancer cells by OESTERREICH, Steffi, WANLENG DENG, SHIMING JIANG, XIAOJIANG CUI, IVANOVA, Margarita, SCHIFF, Rachel, KAIYAN KANG, HADSELL, Darryl L, BEHRENS, Jürgen, LEE, Adrian V

“…E-cadherin is an important mediator of cell-cell interactions, and has been shown to play a crucial role in breast tumor suppression. Its inactivation occurs…”
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Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression by Hadsell, D L, Greenberg, N M, Fligger, J M, Baumrucker, C R, Rosen, J M

“…To test the hypothesis that insulin-like growth factor I (IGF-I) regulates mammary gland development and lactation, the expression of both human (h) IGF-I and…”
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Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein by Keasler, Victor V., Lerat, Herve, Madden, Charles R., Finegold, Milton J., McGarvey, Michael J., Mohammed, Essam M.A., Forbes, Stuart J., Lemon, Stanley M., Hadsell, Darryl L., Grona, Shala J., Hollinger, F. Blaine, Slagle, Betty L.

“…Transgenic mice expressing the full-length HCV coding sequence were crossed with mice that express the HBV X gene-encoded regulatory protein HBx (ATX mice) to…”
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