Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program

Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program

Long COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVID. We used electronic health records available through the Na...

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Bibliographic Details
Published in:Nature communications Vol. 14; no. 1; p. 2914
Main Authors: Brannock, M. Daniel, Chew, Robert F., Preiss, Alexander J., Hadley, Emily C., Redfield, Signe, McMurry, Julie A., Leese, Peter J., Girvin, Andrew T., Crosskey, Miles, Zhou, Andrea G., Moffitt, Richard A., Funk, Michele Jonsson, Pfaff, Emily R., Haendel, Melissa A., Chute, Christopher G.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 22-05-2023
Nature Publishing Group
Nature Portfolio
Subjects:
631/326/596/4130
692/699/255/2514
692/700/459/1748
692/700/478/174
Availability
Cohort analysis
Cohort Studies
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Vaccines
Demographics
Diagnosis
Electronic health records
Electronic medical records
Humanities and Social Sciences
Humans
Immunization
Infections
multidisciplinary
Patients
Phenotypes
Post-Acute COVID-19 Syndrome
Public health
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
United States - epidemiology
Vaccination
United States
United States > US
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Description
Summary:Long COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVID. We used electronic health records available through the National COVID Cohort Collaborative to characterize the association between SARS-CoV-2 vaccination and long COVID diagnosis. Among patients with a COVID-19 infection between August 1, 2021 and January 31, 2022, we defined two cohorts using distinct definitions of long COVID—a clinical diagnosis ( n  = 47,404) or a previously described computational phenotype ( n  = 198,514)—to compare unvaccinated individuals to those with a complete vaccine series prior to infection. Evidence of long COVID was monitored through June or July of 2022, depending on patients’ data availability. We found that vaccination was consistently associated with lower odds and rates of long COVID clinical diagnosis and high-confidence computationally derived diagnosis after adjusting for sex, demographics, and medical history. The extent to which COVID-19 vaccination protects against long COVID is not well understood. Here, the authors use electronic health record data from the United States and find that, for people who received their vaccination prior to infection, vaccination was associated with lower incidence of long COVID.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-38388-7