Search Results - "Hadfield, Kristen D"

Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas by Smith, Miriam J, O'Sullivan, James, Bhaskar, Sanjeev S, Hadfield, Kristen D, Poke, Gemma, Caird, John, Sharif, Saba, Eccles, Diana, Fitzpatrick, David, Rawluk, Daniel, du Plessis, Daniel, Newman, William G, Evans, D Gareth

“…William Newman, Gareth Evans and colleagues report that loss-of-function mutations in SMARCE1 cause an inherited disorder characterized by multiple spinal…”
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MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma by Conte, Ivan, Kristen D. Hadfield, Sara Barbato, Sabrina Carrella, Mariateresa Pizzo, Rajeshwari S. Bhat, Annamaria Carissimo, Marianthi Karali, Louise F. Porter, Jill Urquhart, Sofie Hateley, James O’Sullivan, Forbes D. C. Manson, Stephan C. F. Neuhauss, Sandro Banfi, Graeme C. M. Black

“…Ocular developmental disorders, including the group classified as microphthalmia, anophthalmia, and coloboma (MAC) and inherited retinal dystrophies,…”
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Impaired Tamoxifen Metabolism Reduces Survival in Familial Breast Cancer Patients by NEWMAN, William G, HADFIELD, Kristen D, LATIF, Ayshe, ROBERTS, Stephen A, SHENTON, Andrew, MCHAGUE, Christopher, LALLOO, Fiona, HOWELL, Sacha, EVANS, D. Gareth

“…Purpose: Tamoxifen has been the mainstay adjuvant hormonal treatment for breast cancer for many years. Conversion of tamoxifen to its active metabolite,…”
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Polymorphisms of CYP19A1 and response to aromatase inhibitors in metastatic breast cancer patients by Ferraldeschi, Roberta, Arnedos, Monica, Hadfield, Kristen D., A’Hern, Roger, Drury, Suzie, Wardley, Andrew, Howell, Anthony, Evans, D. Gareth, Roberts, Stephen A., Smith, Ian, Newman, William G., Dowsett, Mitch

“…Single nucleotide polymorphisms (SNPs) in the gene encoding aromatase ( CYP19A1 ) have been associated with differential benefit from letrozole treatment in…”
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EGFR and KRAS mutational analysis and their correlation to survival in pancreatic and periampullary cancer by Oliveira-Cunha, Melissa, Hadfield, Kristen D, Siriwardena, Ajith K, Newman, William

“…Pancreatic and periampullary cancers have a high incidence of activating KRAS mutations. The aim of this study was to determine the incidence of KRAS and EGFR…”
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Pharmacogenetics of aromatase inhibitors by Hadfield, Kristen D, Newman, William G

“…Aromatase inhibitors (AIs) are an important class of endocrine drugs used in the treatment of early and advanced breast cancer in postmenopausal women. A…”
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HtrA1 Inhibits Mineral Deposition by Osteoblasts: REQUIREMENT FOR THE PROTEASE AND PDZ DOMAINS by Hadfield, Kristen D, Rock, Claire Farrington, Inkson, Colette A, Dallas, Sarah L, Sudre, Laure, Wallis, Gillian A, Boot-Handford, Raymond P, Canfield, Ann E

“…HtrA1 is a secreted multidomain protein with serine protease activity. In light of increasing evidence implicating this protein in the regulation of skeletal…”
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Breast cancer susceptibility variants alter risks in familial disease by Latif, Ayse, Hadfield, Kristen D, Roberts, Stephen A, Shenton, Andrew, Lalloo, Fiona, Black, Graeme C M, Howell, Anthony, Evans, D Gareth, Newman, William G

“…Recent candidate and genome-wide association studies have identified variants altering susceptibility to breast cancer. To establish the relevance of these…”
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Involvement of SMARCB1 in Inherited Predisposition to Schwannoma, Meningioma and Rhabdoid Tumours by Smith, Miriam J, Hadfield, Kristen D, Newman, William G, Evans, D. Gareth

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UGT1A128 genotype predicts gastrointestinal toxicity in patients treated with intermediate-dose irinotecan by Ferraldeschi, Roberta, Minchell, Laura J, Roberts, Stephen A, Tobi, Simon, Hadfield, Kristen D, Blackhall, Fiona H, Mullamitha, Saifee, Wilson, Gregory, Valle, Juan, Saunders, Mark, Newman, William G

“…Variants in UGT1A1 have previously been associated with toxicity from irinotecan chemotherapy. We conducted a pragmatic prospective cohort study to establish…”
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Involvement of the SWI/SNF Complex in Familial Meningiomatosis by Smith, Miriam J, Sullivan, James O, Bhaskar, Sanjeev S, Hadfield, Kristen D, Poke, Gemma, Caird, John, Sharif, Saba, Eccles, Diana, Fitzpatrick, David, Rawluk, Daniel, du Plessis, Daniel, van Hoff, Jack, Newman, William G, Evans, D. Gareth

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Exacerbation of hereditary warfarin resistance by azathioprine by Pushpakom, Sudeep P, Gambhir, Nikki, Latif, Ayshe, Hadfield, Kristen D, Campbell, Simon, Newman, William G

“…A 39-year-old Afro-Caribbean man with Crohn disease with recurrent deep vein thromboses and pulmonary emboli was commenced on lifelong warfarin treatment. The…”
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Isolated unilateral vestibular schwannomas do not harbor HRAS mutations by Smith, Miriam J., Hadfield, Kristen D., Ramsden, Richard T., Rutherford, Scott A., King, Andrew T., Newman, William G., Evans, D. Gareth

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HtrA1 Inhibits Mineral Deposition by Osteoblasts by Hadfield, Kristen D., Rock, Claire Farrington, Inkson, Colette A., Dallas, Sarah L., Sudre, Laure, Wallis, Gillian A., Boot-Handford, Raymond P., Canfield, Ann E.

“…HtrA1 is a secreted multidomain protein with serine protease activity. In light of increasing evidence implicating this protein in the regulation of skeletal…”
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Urinary tract effects of HPSE2 mutations by Stuart, Helen M, Roberts, Neil A, Hilton, Emma N, McKenzie, Edward A, Daly, Sarah B, Hadfield, Kristen D, Rahal, Jeffery S, Gardiner, Natalie J, Tanley, Simon W, Lewis, Malcolm A, Sites, Emily, Angle, Brad, Alves, Cláudia, Lourenço, Teresa, Rodrigues, Márcia, Calado, Angelina, Amado, Marta, Guerreiro, Nancy, Serras, Inês, Beetz, Christian, Varga, Rita-Eva, Silay, Mesrur Selcuk, Darlow, John M, Dobson, Mark G, Barton, David E, Hunziker, Manuela, Puri, Prem, Feather, Sally A, Goodship, Judith A, Goodship, Timothy H J, Lambert, Heather J, Cordell, Heather J, Saggar, Anand, Kinali, Maria, Lorenz, Christian, Moeller, Kristina, Schaefer, Franz, Bayazit, Aysun K, Weber, Stefanie, Newman, William G, Woolf, Adrian S

“…Urofacial syndrome (UFS) is an autosomal recessive congenital disease featuring grimacing and incomplete bladder emptying. Mutations of HPSE2, encoding…”
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SMARCB1 mutations are not a common cause of multiple meningiomas by Hadfield, K D, Smith, M J, Trump, D, Newman, W G, Evans, D G

“…Schwannomas and meningiomas are both part of the tumour spectrum of neurofibromatosis type 2 (NF2) and are associated with somatic loss of chromosome 22. They…”
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Abstract A35: SMARCE1 mutations cause inherited multiple spinal meningiomas by Smith, Miriam J., O'Sullivan, James, Bhaskar, Sanjeev S., Hadfield, Kristen D., Poke, Gemma, Caird, John, Sharif, Saba, Eccles, Diana, FitzPatrick, David, Rawluk, Daniel, Plessis, Daniel du, Newman, William G., Evans, D. Gareth

“…Abstract Meningiomas represent approximately one third of all primary central nervous system tumors in adults. Multiple meningiomas are usually associated with…”
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HtrA1-a serine protease that regulates vascular calcification by Inkson, Colette A., Hadfield, Kristen D., Wilkinson, Fiona L., Wallis, Gillian A., Canfield, Ann E.

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Identification of Key Regulators of Chondrocyte Hypertrophy by Hadfield, Kristen D

“…During the pathogenesis of osteoarthritis (OA), certain genes that are characteristically expressed by hypertrophic chondrocytes of the growth plate (e.g type…”
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