Search Results - "Hadebe, Sabelo"

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis by Moreira-Teixeira, Lúcia, Stimpson, Philippa J., Stavropoulos, Evangelos, Hadebe, Sabelo, Chakravarty, Probir, Ioannou, Marianna, Aramburu, Iker Valle, Herbert, Eleanor, Priestnall, Simon L., Suarez-Bonnet, Alejandro, Sousa, Jeremy, Fonseca, Kaori L., Wang, Qian, Vashakidze, Sergo, Rodríguez-Martínez, Paula, Vilaplana, Cristina, Saraiva, Margarida, Papayannopoulos, Venizelos, O’Garra, Anne

“…Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional…”
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Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi by Hadebe, Sabelo, Brombacher, Frank

“…Asthma is a chronic debilitating airway disease affecting millions of people worldwide. Although largely thought to be a disease of the first world, it is now…”
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IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis by Scibiorek, Martyna, Mthembu, Nontobeko, Mangali, Sandisiwe, Ngomti, Amkele, Ikwegbue, Paul, Brombacher, Frank, Hadebe, Sabelo

“…Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier…”
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Author Correction: IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis by Scibiorek, Martyna, Mthembu, Nontobeko, Mangali, Sandisiwe, Ngomti, Amkele, Ikwegbue, Paul, Brombacher, Frank, Hadebe, Sabelo

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Immunoglobulin M in Health and Diseases: How Far Have We Come and What Next? by Jones, Katelyn, Savulescu, Anca F, Brombacher, Frank, Hadebe, Sabelo

“…B lymphocytes are important in secreting antibodies that protect against invading pathogens such as viruses, bacteria, parasites, and also in mediating…”
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C-Type Lectin Receptors in Asthma by Hadebe, Sabelo, Brombacher, Frank, Brown, Gordon D

“…Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is…”
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Respiratory Viral and Bacterial Factors That Influence Early Childhood Asthma by Mthembu, Nontobeko, Ikwegbue, Paul, Brombacher, Frank, Hadebe, Sabelo

“…Asthma is a chronic respiratory condition characterised by episodes of shortness of breath due to reduced airway flow. The disease is triggered by a…”
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Immunogenetics and pharmacogenetics of allergic asthma in Africa by Mabelane, Tshegofatso, Masekela, Refiloe, Dandara, Collet, Hadebe, Sabelo

“…Asthma is a common chronic condition in children and in an African setting is often highly prevalent in urban areas as compared to rural areas. Asthma is a…”
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Associations between Environmental dust composition and Atopic Dermatitis in urban and rural settings by Trikamjee, Thulja, Basera, Wisdom, Botha, Maresa, Facey‐Thomas, Heidi E., Gaunt, Ben, Genuneit, Jon, Gray, Claudia L., Hadebe, Sabelo, Hlela, Carol, Kirstein, Frank, Lunjani, Nonhlanhla, Mankahla, Avumile, Ramjith, Jordache, Levin, Michael, Kalaycı, Ömer

“…Background Environmental exposures are involved in the pathogenesis of the allergic phenotype and in determining which individual triggers a person becomes…”
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IL-4Rα signaling in CD4+CD25+FoxP3+ T regulatory cells restrains airway inflammation via limiting local tissue IL-33 by Khumalo, Jermaine, Kirstein, Frank, Hadebe, Sabelo, Brombacher, Frank

“…Impaired tolerance to innocuous particles during allergic asthma has been linked to increased plasticity of FoxP3+ regulatory T cells (Tregs) reprogramming…”
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Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma by Hadebe, Sabelo, Kirstein, Frank, Fierens, Kaat, Chen, Kong, Drummond, Rebecca A, Vautier, Simon, Sajaniemi, Sara, Murray, Graeme, Williams, David L, Redelinghuys, Pierre, Reinhart, Todd A, Fallert Junecko, Beth A, Kolls, Jay K, Lambrecht, Bart N, Brombacher, Frank, Brown, Gordon D

“…Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found…”
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Characterisation of innate fungal recognition in the lung by Faro-Trindade, Inês, Willment, Janet A, Kerrigan, Ann M, Redelinghuys, Pierre, Hadebe, Sabelo, Reid, Delyth M, Srinivasan, Naren, Wainwright, Helen, Lang, Dirk M, Steele, Chad, Brown, Gordon D

“…The innate recognition of fungi by leukocytes is mediated by pattern recognition receptors (PRR), such as Dectin-1, and is thought to occur at the cell surface…”
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Correction: Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma by Hadebe, Sabelo, Kirstein, Frank, Fierens, Kaat, Chen, Kong, Drummond, Rebecca A, Vautier, Simon, Sajaniemi, Sara, Murray, Graeme, Williams, David L, Redelinghuys, Pierre, Reinhart, Todd A, Junecko, Beth A Fallert, Kolls, Jay K, Lambrecht, Bart N, Brombacher, Frank, Brown, Gordon D

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Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town by Hadebe, Sabelo, Chengalroyen, Melissa, Guler, Reto, Nakedi, Kehilwe, Koch, Anastasia, Makatsa, Mohau, Shey, Muki, Parihar, Suraj P., Bryson, Bryan, Marakalala, Mohlopheni J., Ndlovu, Hlumani

“…Tuberculosis (TB), caused by the highly infectious  Mycobacterium tuberculosis , remains a leading cause of death worldwide, with an estimated 1.6 million…”
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Therapeutic and prophylactic deletion of IL‐4Ra‐signaling ameliorates established ovalbumin induced allergic asthma by Khumalo, Jermaine, Kirstein, Frank, Scibiorek, Martyna, Hadebe, Sabelo, Brombacher, Frank

“…Background Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. IL‐4Rα‐signaling…”
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Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load by Hadebe, Sabelo, Khumalo, Jermaine, Mangali, Sandisiwe, Mthembu, Nontobeko, Ndlovu, Hlumani, Scibiorek, Martyna, Ngomti, Amkele, Kirstein, Frank, Brombacher, Frank

“…B cells play an important role in allergies through secretion of IgE. IL-4 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine…”
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IgM regulates airway hyperresponsiveness in allergic asthma through acetyl choline receptors by Hadebe, Sabelo, Khumalo, Jermaine, Ngomti, Amkele, Mangali, Sandisiwe, Scibiorek, Martyna, Brombacher, Frank

“…Abstract Allergic asthma is a disease driven by T helper 2 (TH2)-type cells secreting interleukin (IL-) 4, 5 and 13. It is characterized by eosinophils, airway…”
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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation by Budu-Aggrey, Ashley, Sobczyk, Maria K., Shringarpure, Suyash S., Reis, Kadri, Reigo, Anu, Nelis, Mari, Tanaka, Nao, Brumpton, Ben M., Thomas, Laurent F., Sole-Navais, Pol, Flatley, Christopher, Espuela-Ortiz, Antonio, Herrera-Luis, Esther, Bork-Jensen, Jette, Marenholz, Ingo, Arnau-Soler, Aleix, Jeong, Ayoung, Fawcett, Katherine A., Baurecht, Hansjorg, Alves, Alexessander Couto, Sleiman, Patrick M., Chang, Xiao, Medina-Gomez, Carolina, Hu, Chen, Xu, Cheng-jian, Qi, Cancan, El-Heis, Sarah, Antoun, Elie, Fadista, João, Wang, Carol A., Thiering, Elisabeth, Kress, Sara, Kothalawala, Dilini M., Kadalayil, Latha, Duan, Jiasong, Zhang, Hongmei, Hoffmann, Thomas, Jorgenson, Eric, Risch, Neil, Njølstad, Pål, Andreassen, Ole A., Johansson, Stefan, Almqvist, Catarina, Gong, Tong, Karlsson, Robert, Magnusson, Patrik K. E., Burchard, Esteban G., Thyssen, Jacob P., Kårhus, Line L., Lau, Susanne, Nöthen, Markus M., Hübner, Norbert, Imboden, Medea, Visconti, Alessia, Falchi, Mario, Bataille, Veronique, Ballardini, Natalia, Hottenga, Jouke J., Müller-Nurasyid, Martina, Ahluwalia, Tarunveer S., Stokholm, Jakob, Chawes, Bo, Schoos, Ann-Marie M., Bustamante, Mariona, Arshad, Syed, German, Chris, Esko, Tõnu, Milani, Lili A., Terao, Chikashi, Abuabara, Katrina, Hveem, Kristian, Jacobsson, Bo, Pino-Yanes, Maria, Strachan, David P., Grarup, Niels, Linneberg, Allan, Lee, Young-Ae, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Melén, Erik, Irvine, Alan D., Jarvis, Deborah, Nijsten, Tamar, Duijts, Liesbeth, Vonk, Judith M., Koppelmann, Gerard H., Godfrey, Keith M., Pennell, Craig E., Sly, Peter D., Holt, Patrick G., Williams, L. Keoki, Bisgaard, Hans, Bønnelykke, Klaus, Simpson, Angela, Murray, Clare, Schikowski, Tamara, Weiss, Scott T., Min, Josine L., Standl, Marie, Paternoster, Lavinia

“…Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the…”
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β-Glucan exacerbates allergic airway responses to house dust mite allergen by Hadebe, Sabelo, Kirstein, Frank, Fierens, Kaat, Redelinghuys, Pierre, Murray, Graeme I, Williams, David L, Lambrecht, Bart N, Brombacher, Frank, Brown, Gordon D

“…β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with…”
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Glucan exacerbates allergic airway responses to house dust mite allergen by Hadebe, Sabelo, Kirstein, Frank, Fierens, Kaat, Redelinghuys, Pierre, Murray, Graeme I, Williams, David L, Lambrecht, Bart N, Brombacher, Frank, Brown, Gordon D

“…[beta]-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. [beta]-Glucan exposure is thought to be associated…”
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