Search Results - "Haddick, Patrick C. G."

Activity- and mTOR-Dependent Suppression of Kv1.1 Channel mRNA Translation in Dendrites by Raab-Graham, Kimberly F, Haddick, Patrick C.G, Jan, Yuh Nung, Jan, Lily Yeh

“…Mammalian target of rapamycin (mTOR) is implicated in synaptic plasticity and local translation in dendrites. We found that the mTOR inhibitor, rapamycin,…”
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Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor by Haddick, Patrick C G, Tom, Irene, Luis, Elizabeth, Quiñones, Gabriel, Wranik, Bernd J, Ramani, Sree R, Stephan, Jean-Philippe, Tessier-Lavigne, Marc, Gonzalez, Lino C

“…The growth and guidance of many axons in the developing nervous system require Netrin-mediated activation of Deleted in Colorectal Cancer (DCC) and other still…”
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VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1 by Ruiz de Almodovar, Carmen, Fabre, Pierre J., Knevels, Ellen, Coulon, Cathy, Segura, Inmaculada, Haddick, Patrick C.G., Aerts, Liesbeth, Delattin, Nicolas, Strasser, Geraldine, Oh, Won-Jong, Lange, Christian, Vinckier, Stefan, Haigh, Jody, Fouquet, Coralie, Gu, Chengua, Alitalo, Kari, Castellani, Valerie, Tessier-Lavigne, Marc, Chedotal, Alain, Charron, Frederic, Carmeliet, Peter

“…Growing axons are guided to their targets by attractive and repulsive cues. In the developing spinal cord, Netrin-1 and Shh guide commissural axons toward the…”
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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge by Nugent, Alicia A., Lin, Karin, van Lengerich, Bettina, Lianoglou, Steve, Przybyla, Laralynne, Davis, Sonnet S., Llapashtica, Ceyda, Wang, Junhua, Kim, Do Jin, Xia, Dan, Lucas, Anthony, Baskaran, Sulochanadevi, Haddick, Patrick C.G., Lenser, Melina, Earr, Timothy K., Shi, Ju, Dugas, Jason C., Andreone, Benjamin J., Logan, Todd, Solanoy, Hilda O., Chen, Hang, Srivastava, Ankita, Poda, Suresh B., Sanchez, Pascal E., Watts, Ryan J., Sandmann, Thomas, Astarita, Giuseppe, Lewcock, Joseph W., Monroe, Kathryn M., Di Paolo, Gilbert

“…Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer’s disease risk. TREM2 senses lipids and mediates myelin…”
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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response by Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick C G, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandman, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

“…The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although…”
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Missense variant in TREML2 protects against Alzheimer's disease by Benitez, Bruno A, Jin, Sheng Chih, Guerreiro, Rita, Graham, Rob, Lord, Jenny, Harold, Denise, Sims, Rebecca, Lambert, Jean-Charles, Gibbs, J. Raphael, Bras, Jose, Sassi, Celeste, Harari, Oscar, Bertelsen, Sarah, Lupton, Michelle K, Powell, John, Bellenguez, Celine, Brown, Kristelle, Medway, Christopher, Haddick, Patrick CG, van der Brug, Marcel P, Bhangale, Tushar, Ortmann, Ward, Behrens, Tim, Mayeux, Richard, Pericak-Vance, Margaret A, Farrer, Lindsay A, Schellenberg, Gerard D, Haines, Jonathan L, Turton, Jim, Braae, Anne, Barber, Imelda, Fagan, Anne M, Holtzman, David M, Morris, John C, Williams, Julie, Kauwe, John S.K, Amouyel, Philippe, Morgan, Kevin, Singleton, Andy, Hardy, John, Goate, Alison M, Cruchaga, Carlos

“…Abstract TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11. Recent studies have…”
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A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains by Haddick, Patrick C G, Larson, Jessica L, Rathore, Nisha, Bhangale, Tushar R, Phung, Qui T, Srinivasan, Karpagam, Hansen, David V, Lill, Jennie R, Pericak-Vance, Margaret A, Haines, Jonathan, Farrer, Lindsay A, Kauwe, John S, Schellenberg, Gerard D, Cruchaga, Carlos, Goate, Alison M, Behrens, Timothy W, Watts, Ryan J, Graham, Robert R, Kaminker, Joshua S, van der Brug, Marcel

“…The common p.D358A variant (rs2228145) in IL-6R is associated with risk for multiple diseases and with increased levels of soluble IL-6R in the periphery and…”
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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models by Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L., Kaminker, Joshua S., van der Brug, Marcel P., Hansen, David V.

“…Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We…”
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DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers by Grievink, Hendrika W., Heuberger, Jules A.A.C., Huang, Fen, Chaudhary, Rinkal, Birkhoff, Willem A.J., Tonn, George R., Mosesova, Sofia, Erickson, Rebecca, Moerland, Matthijs, Haddick, Patrick C.G., Scearce‐Levie, Kimberly, Ho, Carole, Groeneveld, Geert Jan

“…Receptor‐interacting serine/threonine‐protein kinase 1 (RIPK1) regulates inflammation, cytokine release, and necroptotic cell death and is implicated in…”
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VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1 by Ruiz de Almodovar, Carmen, Fabre, Pierre J., Knevels, Ellen, Coulon, Cathy, Segura, Inmaculada, Haddick, Patrick C.G., Aerts, Liesbeth, Delattin, Nicolas, Strasser, Geraldine, Oh, Won-Jong, Lange, Christian, Vinckier, Stefan, Haigh, Jody, Fouquet, Coralie, Gu, Chengua, Alitalo, Kari, Castellani, Valerie, Tessier-Lavigne, Marc, Chedotal, Alain, Charron, Frederic, Carmeliet, Peter

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Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases by Craig, Robert A., De Vicente, Javier, Estrada, Anthony A., Feng, Jianwen A., Lexa, Katrina W., Canet, Mark J., Dowdle, William E., Erickson, Rebecca I., Flores, Brittany N., Haddick, Patrick C. G., Kane, Lesley A., Lewcock, Joseph W., Moerke, Nathan J., Poda, Suresh B., Sweeney, Zachary, Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Yulyaningsih, Ernie, Solanoy, Hilda, Scearce-Levie, Kimberly, Sanchez, Pascal E., Tang, Liwei, Xu, Musheng, Zhang, Rui, Osipov, Maksim

“…Eukaryotic translation initiation factor 2B (eIF2B) is a key component of the integrated stress response (ISR), which regulates protein synthesis and stress…”
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Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates by Palmesino, Elena, Haddick, Patrick C G, Tessier-Lavigne, Marc, Kania, Artur

“…Down syndrome cell adhesion molecule (DSCAM) has mainly been characterized for its function as an adhesion molecule in axon growth and in self-recognition…”
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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis by Craig, Robert A., Fox, Brian M., Hu, Cheng, Lexa, Katrina W., Osipov, Maksim, Thottumkara, Arun P., Larhammar, Martin, Miyamoto, Takashi, Rana, Anil, Kane, Lesley A., Yulyaningsih, Ernie, Solanoy, Hilda, Nguyen, Hoang, Chau, Roni, Earr, Timothy, Kajiwara, Yuji, Fleck, Daniel, Lucas, Anthony, Haddick, Patrick C. G., Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Canet, Mark J., Poda, Suresh B., Scearce-Levie, Kimberly, Srivastava, Ankita, Sweeney, Zachary K., Xu, Musheng, Zhang, Rui, He, Jianrong, Lei, Yanan, Zhuo, Zheng, de Vicente, Javier

“…Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a…”
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Defining the Ligand Specificity of the Deleted in Colorectal Cancer by Haddick, Patrick C. G, Tom, Irene, Luis, Elizabeth, Quiñones, Gabriel, Wranik, Bernd J, Ramani, Sree R, Stephan, Jean-Philippe, Tessier-Lavigne, Marc, Gonzalez, Lino C

“…The growth and guidance of many axons in the developing nervous system require Netrin-mediated activation of Deleted in Colorectal Cancer (DCC) and other still…”
Get full text

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response by Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick CG, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandmann, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

“…The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although…”
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Neuronal activity suppression of Kv1.1 channel mRNA translation in dendrites by Haddick, Patrick C. G

“…Ion channels play crucial roles in a variety of cellular activities. A superfamily of ion channels known as voltage-gated ion channels is responsive to changes…”
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Neuronal activity suppression of Kv1.1 channelmRNA translation in dendrites by Haddick, Patrick C. G

“…Ion channels play crucial roles in a variety of cellular activities. A superfamily of ion channels known as voltage-gated ion channels is responsive to changes…”
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