Lymphoproliferative process with reactive follicular cells in thyroid fine-needle aspiration: A few simple but important diagnostic pearls
Papillary thyroid carcinoma (PTC)Hashimoto's thyroiditisHigh-grade mucosa-associated lymphoid tissue (MALT) lymphomaFollicular neoplasm Answer: B Explanation The aspirates showed abundant polymorphic lymphocytes with lymphohistiocytic tangles showing tingible-body macrophages with relatively sc...
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| Published in: | CytoJournal Vol. 16; no. 1; p. 20 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Pittsford
Wolters Kluwer India Pvt. Ltd
01-01-2019
Medknow Publications and Media Pvt. Ltd Scientific Scholar Wolters Kluwer - Medknow |
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| Online Access: | Get full text |
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| Summary: | Papillary thyroid carcinoma (PTC)Hashimoto's thyroiditisHigh-grade mucosa-associated lymphoid tissue (MALT) lymphomaFollicular neoplasm Answer: B Explanation The aspirates showed abundant polymorphic lymphocytes with lymphohistiocytic tangles showing tingible-body macrophages with relatively scant colloid in the background and with lack of nuclear features of PTC. [3] This may present clinically as an enlarged gland. [...]clinical literature recognizes a significant association between the prevalence of PTC and Hashimoto's thyroiditis (24%–26.6% PTC found in thyroidectomies). Here, sheets/monolayers of thyroid follicular cells arranged in honey-combs are admixed with reactive Hurthle cells present as repair-like groups with school of fish pattern, with significant proportion of colloid in the background. [...]PTC with oncocytic (Hurthle cell) changes should be excluded in oncocytic thyroid neoplasms that show nuclear features of PTC such as ground glass nuclei, intranuclear inclusions and longitudinal nuclear grooves. |
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| ISSN: | 1742-6413 0974-5963 1742-6413 |
| DOI: | 10.4103/cytojournal.cytojournal_5_19 |