Search Results - "Haddad, Dania"

New-Generation Glucokinase Activators: Potential Game-Changers in Type 2 Diabetes Treatment by Haddad, Dania, Dsouza, Vanessa Sybil, Al-Mulla, Fahd, Al Madhoun, Ashraf

“…Achieving glycemic control and sustaining functional pancreatic β-cell activity remains an unmet medical need in the treatment of type 2 diabetes mellitus…”
Get full text

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains by Haddad, Dania, John, Sumi Elsa, Mohammad, Anwar, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad, Nizam, Rasheeba, Al-Qabandi, Sarah, Al Madhoun, Ashraf, Alshukry, Abdullah, Ali, Hamad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
Get full text

Editorial: The role of oxidative stress in metabolic and inflammatory diseases by Klisic, Aleksandra, Ahmad, Rasheed, Haddad, Dania, Bonomini, Francesca, Sindhu, Sardar

Get full text

Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells by Al Madhoun, Ashraf, Haddad, Dania, Al Tarrah, Mustafa, Jacob, Sindhu, Al-Ali, Waleed, Nizam, Rasheeba, Miranda, Lavina, Al-Rashed, Fatema, Sindhu, Sardar, Ahmad, Rasheed, Bitar, Milad S., Al-Mulla, Fahd

“…The imipramine ONC201 has antiproliferative effects in several cancer cell types and activates integrated stress response pathway associated with the induction…”
Get full text

Dental Pulp Stem Cells Derived From Adult Human Third Molar Tooth: A Brief Review by Al Madhoun, Ashraf, Sindhu, Sardar, Haddad, Dania, Atari, Maher, Ahmad, Rasheed, Al-Mulla, Fahd

“…The fields of regenerative medicine and stem cell-based tissue engineering have the potential of treating numerous tissue and organ defects. The use of adult…”
Get full text

Targeting the Metabolic Paradigms in Cancer and Diabetes by Bosso, Mira, Haddad, Dania, Al Madhoun, Ashraf, Al-Mulla, Fahd

“…Dysregulated metabolic dynamics are evident in both cancer and diabetes, with metabolic alterations representing a facet of the myriad changes observed in…”
Get full text

Wharton's jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications by Drobiova, Hana, Sindhu, Sardar, Ahmad, Rasheed, Haddad, Dania, Al-Mulla, Fahd, Al Madhoun, Ashraf

“…Accumulating evidence indicates that most primary Wharton's jelly mesenchymal stem cells (WJ-MSCs) therapeutic potential is due to their paracrine activity,…”
Get full text

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation by Ramachandran, Shaliny, Haddad, Dania, Li, Conglei, Le, Michael X., Ling, Alexanda K., So, Clare C., Nepal, Rajeev M., Gommerman, Jennifer L., Yu, Kefei, Ketela, Troy, Moffat, Jason, Martin, Alberto

“…Class switch recombination (CSR) requires activation-induced deaminase (AID) to instigate double-stranded DNA breaks at the immunoglobulin locus. DNA breaks…”
Get full text

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians by Al Madhoun, Ashraf, Hebbar, Prashantha, Nizam, Rasheeba, Haddad, Dania, Melhem, Motasem, Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Background: Animal and cell model studies have implicated CAV1 in the pathophysiology of metabolic disorders. Our previous studies demonstrated a potential…”
Get full text

Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells by Al Madhoun, Ashraf, Marafie, Sulaiman K, Haddad, Dania, Melhem, Motasem, Abu-Farha, Mohamed, Ali, Hamad, Sindhu, Sardar, Atari, Maher, Al-Mulla, Fahd

“…Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are a valuable tool in stem cell research due to their high proliferation rate, multi-lineage…”
Get full text

Quality of life and nutritional status in peritoneal dialysis patients: a cross-sectional study from Palestine by Ali, Iyad, Haddad, Dania, Soliman, Mostafa A, Al-Sabi, Ahmed, Jebreen, Kamel, Abuzahra, Dana, Shrara, Bakrieh, Ghanayem, Diana, Natour, Nihal, Hassan, Mohanad, Alsedfy, M Yasser, Shellah, Duha, Nawajah, Inad

“…End-stage renal disease (ESRD) is a growing cause of morbidity worldwide. Protein malnutrition is common among patients with ESRD. Peritoneal dialysis (PD)…”
Get full text

ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19 by Al-Mulla, Fahd, Mohammad, Anwar, Al Madhoun, Ashraf, Haddad, Dania, Ali, Hamad, Eaaswarkhanth, Muthukrishnan, John, Sumi Elsa, Nizam, Rasheeba, Channanath, Arshad, Abu-Farha, Mohamed, Ahmad, Rasheed, Abubaker, Jehad, Thanaraj, Thangavel Alphonse

“…The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly variable in different global populations. SARS-CoV-2 uses ACE2 as a cell…”
Get full text

Adipose Tissue Caveolin-1 Upregulation in Obesity Involves TNF-α/NF-κB Mediated Signaling by Al Madhoun, Ashraf, Kochumon, Shihab, Haddad, Dania, Thomas, Reeby, Nizam, Rasheeba, Miranda, Lavina, Sindhu, Sardar, Bitar, Milad S, Ahmad, Rasheed, Al-Mulla, Fahd

“…Obesity is characterized by chronic low-grade inflammation. Obese people have higher levels of caveolin-1 (CAV1), a structural and functional protein present…”
Get full text

ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding by Al-Rashed, Fatema, Haddad, Dania, Al Madhoun, Ashraf, Sindhu, Sardar, Jacob, Texy, Kochumon, Shihab, Obeid, Lina M., Al-Mulla, Fahd, Hannun, Yusuf A., Ahmad, Rasheed

“…Foamy and inflammatory macrophages play pathogenic roles in metabolic disorders. However, the mechanisms that promote foamy and inflammatory macrophage…”
Get full text

Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study by M. Abdel-Halim, Samy, Madhoun, Ashraf Al, Nizam, Rasheeba, Melhem, Motasem, Cherian, Preethi, Al-Khairi, Irina, Haddad, Dania, Abu-Farha, Mohamed, Abubaker, Jehad, Bitar, Milad S, Al-Mulla, Fahd

“…Adenylate cyclases (ADCYs) catalyze the conversion of ATP to cAMP, an important co-factor in energy homeostasis. Giving ADCYs role in obesity, diabetes and…”
Get full text

Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New Binding Site for the Early B-Cell Factor 1 That Instigates Adipose Tissue CAV1 Protein Overexpression by Al Madhoun, Ashraf, Haddad, Dania, Nizam, Rasheeba, Miranda, Lavina, Kochumon, Shihab, Thomas, Reeby, Thanaraj, Thangavel Alphonse, Ahmad, Rasheed, Bitar, Milad S, Al-Mulla, Fahd

“…Caveolin-1 (CAV1) is implicated in the pathophysiology of diabetes and obesity. Previously, we demonstrated an association between the CAV1 rs1997623 C > A…”
Get full text

Incidence of Type 2 Diabetes in Kuwaiti Children and Adolescents: Results From the Childhood-Onset Diabetes Electronic Registry (CODeR) by Al-Kandari, Hessa, Al-Abdulrazzaq, Dalia, Davidsson, Lena, Sharma, Prem, Al-Tararwa, Abeer, Mandani, Fawziya, Al-Shawaf, Faisal, Al-Hussaini, Fatma, Qabazard, Mariam, Haddad, Dania, Al-Mahdi, Maria, Al-Jasser, Fahad, Al-Anzi, Ayed, Al-Sanea, Hala, Al-Basari, Iman, Al-Adsani, Afaf, Shaltout, Azza, AbdulRasoul, Mejedah

“…Type 2 Diabetes (T2D) in children and adolescents has become an important public health concern due to the increase in childhood obesity worldwide. The urgency…”
Get full text

Seeking sense of antisense switch transcripts by Haddad, Dania, Puget, Nadine, Laviolette-Malirat, Nathalie, Conte, Caroline, Khamlichi, Ahmed Amine

“…In B lymphocytes, class switch recombination (CSR) machinery targets highly repetitive sequences, called switch (S) sequences, in the constant domain of the…”
Get full text

Role of Caveolin-1 in Diabetes and Its Complications by Al-Mulla, Fahd, Nizam, Rasheeba, Al Madhoun, Ashraf, Haddad, Dania

“…It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus,…”
Get full text

1278-P: The Tale of Caveolin 1 rs1997623 Variant in Obesity and Metabolic Syndrome by MADHOUN, ASHRAF AL, HADDAD, DANIA, KOCHUMON, SHIHAB P., NIZAM, RASHEEBA, JACOB, SINDHU, SINDHU, SARDAR T., AHMAD, RASHEED, ALMULLA, FAHD

“…We Have previously established that caveolin-1 (CAV1) rs1997623 C/A variant is associated with metabolic syndrome in obese children (PMID: 30622557) and adults…”
Get full text