Search Results - "Hadano, Shinji"

AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin by Rossi Sebastiano, Matteo, Ermondi, Giuseppe, Hadano, Shinji, Caron, Giulia

“…•AI-based protein structure databases support rare disease drug discovery programs.•The human AlphaFoldDB alsin model is in line with homology modeling…”
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The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2 by Shimakura, Kento, Sato, Kai, Mitsui, Shun, Ono, Suzuka, Otomo, Asako, Hadano, Shinji

“…ALS2, a product of the causative gene for familial amyotrophic lateral sclerosis (ALS) type 2, plays a pivotal role in the regulation of endosome dynamics by…”
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Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes by Sato, Kai, Suzuki-Utsunomiya, Kyoko, Mitsui, Shun, Ono, Suzuka, Shimakura, Kento, Otomo, Asako, Hadano, Shinji

“…ALS2/alsin, the causative gene product for a number of juvenile recessive motor neuron diseases, acts as a guanine nucleotide exchange factor (GEF) for Rab5,…”
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ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes by Ono, Suzuka, Otomo, Asako, Murakoshi, Shuji, Mitsui, Shun, Sato, Kai, Fukuda, Mitsunori, Hadano, Shinji

“…Small GTPase Rab17 has been shown to regulate a wide range of physiological processes including cell migration in tumor cells and dendrite morphogenesis in…”
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High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device by Otomo, Asako, Ono, Suzuka, Sato, Kai, Mitsui, Shun, Shimakura, Kento, Kimura, Hiroshi, Hadano, Shinji

“…•A modified microfluidic device for high-throughput axonal transport analysis is developed.•Number of motile acidic vesicles in axons is increased by mutant…”
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Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies by Rossi Sebastiano, Matteo, Ermondi, Giuseppe, Sato, Kai, Otomo, Asako, Hadano, Shinji, Caron, Giulia

“…Infantile onset hereditary spastic paralysis (IAHSP) is a rare neurological disease diagnosed in less than 50 children worldwide. It is transmitted with a…”
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A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection by Kanno, Takuya, Yasutake, Kaori, Tanaka, Kazunori, Hadano, Shinji, Ikeda, Joh-E

“…Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels…”
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SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron by Mitsui, Shun, Otomo, Asako, Sato, Kai, Ishiyama, Masahito, Shimakura, Kento, Okada-Yamaguchi, Chisa, Warabi, Eiji, Yanagawa, Toru, Aoki, Masashi, Shang, Hui-Fang, Hadano, Shinji

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective loss of motor neurons in the brain and spinal cord…”
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Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice by Hadano, Shinji, Mitsui, Shun, Pan, Lei, Otomo, Asako, Kubo, Mizuki, Sato, Kai, Ono, Suzuka, Onodera, Wakana, Abe, Koichiro, Chen, XuePing, Koike, Masato, Uchiyama, Yasuo, Aoki, Masashi, Warabi, Eiji, Yamamoto, Masayuki, Ishii, Tetsuro, Yanagawa, Toru, Shang, Hui-Fang, Yoshii, Fumihito

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by a selective loss of motor neurons in the brain and spinal cord…”
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Rare CRHR2 and GRM8 variants identified as candidate factors associated with eating disorders in Japanese patients by whole exome sequencing by Oka, Akira, Hadano, Shinji, Ueda, Mahoko Takahashi, Nakagawa, So, Komaki, Gen, Ando, Tetsuya

“…Eating disorders (EDs) are a type of psychiatric disorder characterized by pathological eating and related behavior and considered to be highly heritable. The…”
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Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B by Hayashi, Hideki, Wang, Ting, Tanaka, Masayuki, Ogiwara, Sanae, Okada, Chisa, Ito, Masatoshi, Fukunishi, Nahoko, Iida, Yumi, Nakamura, Ayaka, Sasaki, Ayumi, Amano, Shunji, Yoshida, Kazuhiro, Otomo, Asako, Ohtsuka, Masato, Hadano, Shinji, Trajkovic, Vladimir

“…The autophagy-endolysosomal pathway is an evolutionally conserved degradation system that is tightly linked to a wide variety of physiological processes…”
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Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures by Otomo, Asako, Ueda, Mahoko Takahashi, Fujie, Toshinori, Hasebe, Arihiro, Suematsu, Yoshitaka, Okamura, Yosuke, Takeoka, Shinji, Hadano, Shinji, Nakagawa, So

“…Synthetic biodegradable polymers including poly(lactic acid) (PLA) are attractive cell culture substrates because their surfaces can be micropatterned to…”
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Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking by Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E

“…ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involved in macropinocytosis-associated endosome fusion and trafficking, and…”
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Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis by Chen, YongPing, Wei, QianQian, Chen, XuePing, Li, ChunYu, Cao, Bei, Ou, RuWei, Hadano, Shinji, Shang, Hui-Fang

“…Accumulating evidence indicates that miRNAs play an important role in the development of amyotrophic lateral sclerosis (ALS). Most of previous studies on miRNA…”
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De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs by Motosugi, Nami, Sugiyama, Akiko, Okada, Chisa, Otomo, Asako, Umezawa, Akihiro, Akutsu, Hidenori, Hadano, Shinji, Fukuda, Atsushi

“…Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST…”
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Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis by Tanaka, Kazunori, Kanno, Takuya, Yanagisawa, Yoshiko, Yasutake, Kaori, Hadano, Shinji, Yoshii, Fumihito, Ikeda, Joh-E

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Since…”
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Six SQSTM1 mutations in a Chinese amyotrophic lateral sclerosis cohort by Yang, Yi, Tang, Lu, Zhang, Nan, Pan, Lei, Hadano, Shinji, Fan, Dongsheng

“…The purpose of this study was to identify SQSTM1 gene mutations, estimate survival based on the progression rate of the revised amyotrophic lateral sclerosis…”
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Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases by Otomo, Asako, Pan, Lei, Hadano, Shinji

“…Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of incurable motor neuron diseases (MNDs) characterized by a selective loss of upper and lower…”
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Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss by Oka, Akira, Takagi, Atsushi, Komiyama, Etsuko, Yoshihara, Nagisa, Mano, Shuhei, Hosomichi, Kazuyoshi, Suzuki, Shingo, Haida, Yuko, Motosugi, Nami, Hatanaka, Tomomi, Kimura, Minoru, Ueda, Mahoko Takahashi, Nakagawa, So, Miura, Hiromi, Ohtsuka, Masato, Tanaka, Masayuki, Komiyama, Tomoyoshi, Otomo, Asako, Hadano, Shinji, Mabuchi, Tomotaka, Beck, Stephan, Inoko, Hidetoshi, Ikeda, Shigaku

“…Alopecia areata (AA) is considered a highly heritable, T-cell-mediated autoimmune disease of the hair follicle. However, no convincing susceptibility gene has…”
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The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis by Kunita, Ryota, Otomo, Asako, Mizumura, Hikaru, Suzuki-Utsunomiya, Kyoko, Hadano, Shinji, Ikeda, Joh-E

“…Mutations in the ALS2 gene cause a number of recessive motor neuron diseases, indicating that the ALS2 protein (ALS2/alsin) is vital for motor neurons. ALS2…”
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