Urinary sodium, potassium and aldosterone in Duchenne muscular dystrophy

Four adolescent boys with Duchenne (progressive) muscular dystrophy (DMD) of 10-11 years duration and six normal boys of similar age were studied on a metabolism ward for 22 days. Sodium and potassium intake was as follows: Period I, Na 60 mEq, K 60 mEq; Period II, Na 10, K 60; Period III, Na 10, K...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 44; no. 1; p. 185
Main Authors:	Garst, J B, Vignos, Jr, P J, Hadaday, M, Matthews, D N
Format:	Journal Article
Language:	English
Published:	United States 01-01-1977
Subjects:	Adolescent Aldosterone - urine Humans Male Muscular Dystrophies - urine Potassium - urine Sodium - urine
Online Access:	Get more information
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Summary:	Four adolescent boys with Duchenne (progressive) muscular dystrophy (DMD) of 10-11 years duration and six normal boys of similar age were studied on a metabolism ward for 22 days. Sodium and potassium intake was as follows: Period I, Na 60 mEq, K 60 mEq; Period II, Na 10, K 60; Period III, Na 10, K 95-150; Period IV, Na 60, K 60. The differences between the DMD group and the group of normal boys for sodium and potassium in serum and urine and for urinary aldosterone were not significant. These findings show that the pathologically elevated sodium-potassium ratio in skeletal muscle of patients with DMD is not due to increased aldosterone or other causes of renal wastage of potassium.
ISSN:	0021-972X
DOI:	10.1210/jcem-44-1-185