Search Results - "Hadac, EM"

Novel Benzodiazepine Photoaffinity Probe Stereoselectively Labels a Site Deep within the Membrane-Spanning Domain of the Cholecystokinin Receptor by Hadac, Elizabeth M, Dawson, Eric S, Darrow, James W, Sugg, Elizabeth E, Lybrand, Terry P, Miller, Laurence J

“…An understanding of the molecular basis of drug action provides opportunities for refinement of drug properties and for development of more potent and…”
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Reengineering paramyxovirus tropism by Hadac, Elizabeth M., Peng, Kah-Whye, Nakamura, Takafumi, Russell, Stephen J.

“…Receptor specificity is a critical determinant of viral tropism, but the capacity of viruses to switch to alternative receptors has not been extensively…”
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Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors. STUDIES OF CHIMERIC RECEPTORS by Holtmann, Martin H., Hadac, Elizabeth M., Miller, Laurence J.

“…Secretin and vasoactive intestinal polypeptide (VIP) receptors are closely related G protein-coupled receptors in a recently described family possessing a…”
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Demonstration of a Direct Interaction between Residue 22 in the Carboxyl-terminal Half of Secretin and the Amino-terminal Tail of the Secretin Receptor Using Photoaffinity Labeling by Dong, Maoqing, Wang, Yan, Pinon, Delia I., Hadac, Elizabeth M., Miller, Laurence J.

“…An understanding of the molecular basis of hormonal activation of receptors provides important insights for drug design. Toward this end, intrinsic…”
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Direct Identification of a Distinct Site of Interaction between the Carboxyl-terminal Residue of Cholecystokinin and the Type A Cholecystokinin Receptor Using Photoaffinity Labeling by Ji, Zongshi, Hadac, Elizabeth M., Henne, Randel M., Patel, Sunil A., Lybrand, Terry P., Miller, Laurence J.

“…Mechanisms of ligand binding and activation of G protein-coupled receptors are particularly important, due to their ubiquitous expression and potential as drug…”
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Identification of an Interaction between Residue 6 of the Natural Peptide Ligand and a Distinct Residue within the Amino-terminal Tail of the Secretin Receptor by Dong, M, Wang, Y, Hadac, E M, Pinon, D I, Holicky, E, Miller, L J

“…Photoaffinity labeling is a powerful tool for the characterization of the molecular basis of ligand binding. We recently used this technique to demonstrate the…”
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Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor by Zang, Mengwei, Dong, Maoqing, Pinon, Delia I, Ding, Xi-Qin, Hadac, Elizabeth M, Li, Zhijun, Lybrand, Terry P, Miller, Laurence J

“…The amino-terminal domain of class B G protein-coupled receptors is critically important for natural peptide agonist binding and action. The precise role it…”
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Differential spatial approximation between cholecystokinin residue 30 and receptor residues in active and inactive conformations by Dong, Maoqing, Hadac, Elizabeth M, Pinon, Delia I, Miller, Laurence J

“…Understanding the structures of active and inactive agonist- and antagonist-bound receptor complexes is of great interest. In this work, we focus on position…”
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Direct Identification of a Second Distinct Site of Contact between Cholecystokinin and Its Receptor by Hadac, Elizabeth M., Pinon, Delia I., Ji, Zongshi, Holicky, Eileen L., Henne, Randal M., Lybrand, Terry P., Miller, Laurence J.

“…We have developed a biologically active analogue of cholecystokinin (CCK) that incorporates a photolabile benzoylphenylalanine (Bpa) moiety in the middle of…”
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B591 Infectious RNA: A Novel Therapeutic Modality for Myeloma by Russell, SJ, Hadac, EM, Kelly, EJ

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B592 Retargeted Coxsackievirus A21 for Myeloma Therapy by Russell, SJ, Kelly, EJ, Hadac, EM, Greiner, SM

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Structural insights into the amino-terminus of the secretin receptor: I. Status of cysteine and cystine residues by Asmann, Y W, Dong, M, Ganguli, S, Hadac, E M, Miller, L J

“…The secretin receptor is prototypic of the class II family of G protein-coupled receptors, with a long extracellular amino-terminal domain containing six…”
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Multiple Extracellular Loop Domains Contribute Critical Determinants for Agonist Binding and Activation of the Secretin Receptor by Holtmann, M H, Ganguli, S, Hadac, E M, Dolu, V, Miller, L J

“…Distinct themes exist for ligand-binding domains of G protein-coupled receptors. The secretin receptor is prototypic of a recently described family in this…”
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Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis by Ganguli, S C, Park, C G, Holtmann, M H, Hadac, E M, Kenakin, T P, Miller, L J

“…G protein-coupled receptors initiate signaling cascades after associating with heterotrimeric G proteins. This is typically initiated by agonist binding, but…”
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A Peptide Agonist Acts by Occupation of a Monomeric G Protein-Coupled Receptor:  Dual Sites of Covalent Attachment to Domains Near TM1 and TM7 of the Same Molecule Make Biologically Significant Domain-Swapped Dimerization Unlikely by Hadac, Elizabeth M, Ji, Zongshi, Pinon, Delia I, Henne, Randal M, Lybrand, Terry P, Miller, Laurence J

“…Membrane receptor dimerization is a well-established event for initiation of signaling at growth factor receptors and has been postulated to exist for G…”
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Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation by Park, C G, Ganguli, S C, Pinon, D I, Hadac, E M, Miller, L J

“…Agonist action at receptors is highly specific, affected by the structure of both ligand and receptor. Chimeric constructs of structurally related receptors…”
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Identification of Peptide Ligand-binding Domains within the Human Motilin Receptor Using Photoaffinity Labeling by Coulie, Bernard, Matsuura, Bunzo, Dong, Maoqing, Hadac, Elizabeth M., Pinon, Delia I., Feighner, Scott D., Howard, Andrew D., Miller, Laurence J.

“…The cDNA encoding the human motilin receptor was recently cloned and found to represent a G protein-coupled receptor that is structurally related to the growth…”
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Relationship between native and recombinant cholecystokinin receptors : Role of differential glycosylation by HADAC, E. M, GHANEKAR, D. V, HOLICKY, E. L, PINON, D. I, DOUGHERTY, R. W, MILLER, L. J

“…In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct…”
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Molecular characterization and organ distribution of type A and B cholecystokinin receptors in cynomolgus monkey by Holicky, E L, Hadac, E M, Ding, X Q, Miller, L J

“…Differences in the molecular structure or organ distribution of receptors can limit the usefulness of a given species for drug studies. In this work, we have…”
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Structurally related peptide agonist, partial agonist, and antagonist occupy a similar binding pocket within the cholecystokinin receptor. Rapid analysis using fluorescent photoaffinity labeling probes and capillary electrophoresis by Dong, M, Ding, X Q, Pinon, D I, Hadac, E M, Oda, R P, Landers, J P, Miller, L J

“…The molecular basis of ligand binding to receptors provides important insights for drug development. Here, we explore domains of the cholecystokinin (CCK)…”
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