Search Results - "Haczeyni, Fahrettin"

Mouse models of non‐alcoholic steatohepatitis: A reflection on recent literature by Haczeyni, Fahrettin, Yeh, Matthew M, Ioannou, George N, Leclercq, Isabelle A, Goldin, Robert, Dan, Yock Young, Yu, Jun, Teoh, Narcissus C, Farrell, Geoffrey C

“…Non‐alcoholic steatohepatitis (NASH) is strongly associated with overnutrition, insulin resistance, and predisposition to type 2 diabetes. To critically…”
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The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice by Haczeyni, Fahrettin, Wang, Hans, Barn, Vanessa, Mridha, Auvro R., Yeh, Matthew M., Haigh, W. Geoffrey, Ioannou, George N., Choi, Yun‐Jung, McWherter, Charles A., Teoh, Narcissus C.‐H., Farrell, Geoffrey C.

“…Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis (NASH) pathogenesis. To date, only weight loss fully reverses NASH…”
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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice by Mridha, Auvro R, Wree, Alexander, Robertson, Avril A.B, Yeh, Matthew M, Johnson, Casey D, Van Rooyen, Derrick M, Haczeyni, Fahrettin, Teoh, Narci C.-H, Savard, Christopher, Ioannou, George N, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, Feldstein, Ariel E, Farrell, Geoffrey C

“…Graphical abstract…”
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TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival by Mridha, Auvro R, Haczeyni, Fahrettin, Yeh, Matthew M, Haigh, W Geoffrey, Ioannou, George N, Barn, Vanessa, Ajamieh, Hussam, Adams, Leon, Hamdorf, Jeffrey M, Teoh, Narci C, Farrell, Geoffrey C

“…Background and aims TLR9 deletion protects against steatohepatitis due to choline-amino acid depletion and high-fat diet. We measured in human non-alcoholic…”
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Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice by Haczeyni, Fahrettin, Poekes, Laurence, Wang, Hans, Mridha, Auvro R., Barn, Vanessa, Geoffrey Haigh, W., Ioannou, George N., Yeh, Matthew M., Leclercq, Isabelle A., Teoh, Narcissus C., Farrell, Geoffrey C.

“…Objective Nonalcoholic steatohepatitis (NASH) is the outcome of interactions between overnutrition, energy metabolism, and adipose function. Obeticholic acid…”
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Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice by Haczeyni, Fahrettin, Barn, Vanessa, Mridha, Auvro R., Yeh, Matthew M., Estevez, Emma, Febbraio, Mark A., Nolan, Christopher J., Bell‐Anderson, Kim S., Teoh, Narci C., Farrell, Geoffrey C.

“…Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose…”
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Voluntary exercise improves metabolic and hepatic phenotypes in dietary but not metabolic obesity in male mice by Haczeyni, Fahrettin, Barn, Vanessa, Wang, Hans, Yeh, Matthew M., Teoh, Narci, Farrell, Geoffrey

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