Search Results - "Hackfeld, Linda C"

Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming by Baljinnyam, Tuvshintugs, Sowers, Mark L, Hsu, Chia Wei, Conrad, James W, Herring, Jason L, Hackfeld, Linda C, Sowers, Lawrence C

“…The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly,…”
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A combinatorial system to examine the enzymatic repair of multiply damaged DNA substrates by Hsu, Chia Wei, Conrad, James W, Sowers, Mark L, Baljinnyam, Tuvshintugs, Herring, Jason L, Hackfeld, Linda C, Hatch, Sandra S, Sowers, Lawrence C

“…DNA damage drives genetic mutations that underlie the development of cancer in humans. Multiple pathways have been described in mammalian cells which can…”
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DNA Base Excision Repair Intermediates Influence Duplex-Quadruplex Equilibrium by Sowers, Mark L, Conrad, James W, Chang-Gu, Bruce, Cherryhomes, Ellie, Hackfeld, Linda C, Sowers, Lawrence C

“…Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary…”
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Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase by Hsu, Chia Wei, Sowers, Mark L., Baljinnyam, Tuvshintugs, Herring, Jason L., Hackfeld, Linda C., Tang, Hui, Zhang, Kangling, Sowers, Lawrence C.

“…The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic…”
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Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming by Tuvshintugs Baljinnyam, Mark L. Sowers, Chia Wei Hsu, James W. Conrad, Jason L. Herring, Linda C. Hackfeld, Lawrence C. Sowers

“…The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly,…”
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Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing by Baljinnyam, Tuvshintugs, Conrad, James W., Sowers, Mark L., Chang-Gu, Bruce, Herring, Jason L., Hackfeld, Linda C., Zhang, Kangling, Sowers, Lawrence C.

“…Recently, we constructed a hybrid thymine DNA glycosylase (hyTDG) by linking a 29-amino acid sequence from the human thymine DNA glycosylase with the catalytic…”
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Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1‑Methylphenanthrene and 9‑Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells by Huang, Meng, Mesaros, Clementina, Hackfeld, Linda C, Hodge, Richard P, Blair, Ian A, Penning, Trevor M

“…Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) is the major human health hazard associated with the Deepwater Horizon oil spill. Alkylated…”
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Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells by Meng, Quanxin, Redetzke, Diana L., Hackfeld, Linda C., Hodge, Richard P., Walker, Dale M., Walker, Vernon E.

“…The carcinogenicity of 1,3-butadiene (BD) is related to its bioactivation to several DNA-reactive metabolites; accumulating evidence suggests that the…”
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Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct by Yoon, Jung-Hoon, Hodge, Richard P., Hackfeld, Linda C., Park, Jeseong, Roy Choudhury, Jayati, Prakash, Satya, Prakash, Louise

“…Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from metabolic oxidation of polyamines, and it is a…”
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Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells by Huang, Meng, Mesaros, Clementina, Hackfeld, Linda C, Hodge, Richard P, Zang, Tianzhu, Blair, Ian A, Penning, Trevor M

“…Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) in the food chain is the major human health hazard associated with the Deepwater Horizon oil…”
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Metabolism of an Alkylated Polycyclic Aromatic Hydrocarbon 5‑Methylchrysene in Human Hepatoma (HepG2) Cells by Huang, Meng, Zhang, Li, Mesaros, Clementina, Hackfeld, Linda C, Hodge, Richard P, Blair, Ian A, Penning, Trevor M

“…Exposure to polycyclic aromatic hydrocarbons (PAHs) in the food chain is the major human health hazard associated with the Deepwater Horizon oil spill…”
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Synthesis and Mutagenesis of the Butadiene-Derived N3 2‘-Deoxyuridine Adducts by Fernandes, Priscilla H, Hackfeld, Linda C, Kozekov, Ivan D, Hodge, Richard P, Lloyd, R. Stephen

“…1,3-Butadiene is a known carcinogen and mutagen that acts through a variety of metabolic intermediates that react with DNA, forming stable and unstable lesions…”
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Mutagenicity of stereochemical configurations of 1,3-butadiene epoxy metabolites in human cells by Meng, Ryan Q, Hackfeld, Linda C, Hedge, Richard P, Wisse, Lynne A, Redetzke, Diana L, Walker, Vernon E

“…The mutagenic and carcinogenic effects of 1,3-butadiene (BD*) are related to its bioactivation to several DNA-reactive metabolites, including…”
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