Search Results - "Hackett, Brian P"

Mutations in the thyroid transcription factor gene NKX2-1 result in decreased expression of SFTPB and SFTPC by Attarian, Stephanie J, Leibel, Sandra L, Yang, Ping, Alfano, Danielle N, Hackett, Brian P, Cole, F Sessions, Hamvas, Aaron

“…Background Mutations in the NK2 homeobox 1 ( NKX2-1 ) gene are associated with lung disease in infants and children. We hypothesize that disruption of normal…”
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Neuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium by Akuamoah-Boateng, Gloria, Buttafuoco, Kayla A., Sutton, Courtney C., Hackett, Brian P.

“…In recent times, atypical antipsychotics are increasingly being used in the neonatal intensive care unit (NICU) for the management of neonatal delirium. As the…”
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Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells by Gomperts, Brigitte N, Gong-Cooper, Xiulan, Hackett, Brian P

“…The forkhead box transcription factor Foxj1 is required for cilia formation and left-right axis determination. To define the role of Foxj1 in ciliogenesis,…”
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Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome by Wambach, Jennifer A, Yang, Ping, Wegner, Daniel J, Heins, Hillary B, Kaliberova, Lyudmila N, Kaliberov, Sergey A, Curiel, David T, White, Frances V, Hamvas, Aaron, Hackett, Brian P, Cole, F Sessions

“…Mutations in the ATP-binding cassette transporter A3 gene (ABCA3) result in severe neonatal respiratory distress syndrome and childhood interstitial lung…”
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Roles of the Foxj1 and Inv genes in the left–right determination of internal organs in mice by Tamakoshi, Tomoki, Itakura, Tatsuo, Chandra, Abhishek, Uezato, Tadayoshi, Yang, Zhi, Xue, Xiao-Dong, Wang, Bo, Hackett, Brian P., Yokoyama, Tatsuhiko, Miura, Naoyuki

“…In Foxj1 knockout mice, half show situs solitus while the other half show situs inversus, which means a random determination of the left–right axis. In…”
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Functional characterization of biallelic RTTN variants identified in an infant with microcephaly, simplified gyral pattern, pontocerebellar hypoplasia, and seizures by Wambach, Jennifer A., Wegner, Daniel J., Yang, Ping, Shinawi, Marwan, Baldridge, Dustin, Betleja, Ewelina, Shimony, Joshua S., Spencer, David, Hackett, Brian P., Andrews, Marisa V., Ferkol, Thomas, Dutcher, Susan K., Mahjoub, Moe R., Cole, F. Sessions

“…Background Biallelic deleterious variants in RTTN , which encodes rotatin, are associated with primary microcephaly, polymicrogyria, seizures, intellectual…”
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Risk factors and prognostic significance of altered left ventricular geometry in preterm infants by Choudhry, Swati, Salter, Amber, Cunningham, Tyler W., Levy, Philip T., Hackett, Brian P., Singh, Gautam K., Johnson, Mark C.

“…Objective: Left ventricular (LV) hypertrophy (LVH) predicts adverse cardiac events in adults. We sought to determine the risk factors and prognostic…”
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IL-13 Regulates Cilia Loss and foxj1 Expression in Human Airway Epithelium by Gomperts, Brigitte N, Kim, Linda J, Flaherty, Scott A, Hackett, Brian P

“…Mucociliary clearance is essential to the defense mechanisms of the respiratory system. Loss of normal mucociliary clearance contributes to the pathogenesis of…”
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Surfactant Protein-C Promoter Variants Associated With Neonatal Respiratory Distress Syndrome Reduce Transcription by Wambach, Jennifer A, Yang, Ping, Wegner, Daniel J, An, Ping, Hackett, Brian P, Cole, F S, Hamvas, Aaron

“…Dominant mutations in coding regions of the surfactant protein-C gene, SFTPC , cause respiratory distress syndrome (RDS) in infants. However, the contribution…”
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Progressive Lung Disease and Surfactant Dysfunction with a Deletion in Surfactant Protein C Gene by Hamvas, Aaron, Nogee, Lawrence M, White, Frances V, Schuler, Pamela, Hackett, Brian P, Huddleston, Charles B, Mendeloff, Eric N, Hsu, Fong-Fu, Wert, Susan E, Gonzales, Linda W, Beers, Michael F, Ballard, Philip L

“…Mutations in the surfactant protein (SP)-C gene are responsible for familial and sporadic interstitial lung disease (ILD). The consequences of such mutations…”
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Left–right axis malformations in man and mouse by Casey, Brett, Hackett, Brian P

“…The study of left–right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left–right axis…”
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Foxj1 regulates asymmetric gene expression during left–right axis patterning in mice by Zhang, Min, Bolfing, Mary F., Knowles, Heather J., Karnes, Hope, Hackett, Brian P.

“…Mice with a targeted mutation of the foxj1 gene demonstrate either D- or L-looping of the embryonic cardiac tube. Foxj1 is expressed in ventral cells of the…”
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Formation and malformation of the vertebrate left-right axis by Hackett, Brian P

“…Despite an externally symmetric body plan, the internal viscera of all vertebrates are asymmetric with respect to the left-right body axis. Determination of…”
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Primary Structure of Hepatocyte Nuclear Factor/Forkhead Homologue 4 and Characterization of Gene Expression in the Developing Respiratory and Reproductive Epithelium by Hackett, Brian P., Brody, Steven L., Liang, Maowei, Zeitz, Ivan D., Bruns, Luke A., Gitlin, Jonathan D.

“…Members of the winged helix/forkhead family of transcription factors are believed to play a role in cell-specific gene expression. A cDNA encoding a member of…”
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A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium by Pelletier, G J, Brody, S L, Liapis, H, White, R A, Hackett, B P

“…Members of the forkhead/winged-helix transcription factor family play crucial roles during vertebrate development. A human hepatocyte nuclear factor/forkhead…”
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Cell-Specific Expression of a Clara Cell Secretory Protein-Human Growth Hormone Gene in the Bronchiolar Epithelium of Transgenic Mice by Hackett, Brian P., Gitlin, Jonathan D.

“…Clara cell secretory protein (CCSP) is an abundant 10-kDa protein synthesized and secreted by nonciliated epithelial cells lining the respiratory and terminal…”
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Structural Characterization of the MouseHfh4Gene, a Developmentally Regulated Forkhead Family Member by Brody, Steven L., Hackett, Brian P., White, Robert A.

“…Hepatocyte nuclear factor-3/forkhead homologue 4 (HFH-4) is a forkhead/winged-helix transcription factor family member that has a unique temporal and spatial…”
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Intraoperative localization of small intestinal bleeding in an infant by methylene blue injection: A case report by Mazziotti, Mark V, Muldowney, Sean, Darcy, Michael, Hackett, Brian P, Skinner, Michael A

“…During the evaluation of patients with profuse gastrointestinal bleeding, it is often difficult to accurately localize bleeding sites in the small intestine…”
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Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry by Chen, J, Knowles, H J, Hebert, J L, Hackett, B P

“…Winged helix transcription factors play important roles in cellular differentiation and cell-specific gene expression. To define the role of the winged helix…”
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Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription by Wambach, Jennifer A, Yang, Ping, Wegner, Daniel J, An, Ping, Hackett, Brian P, Cole, F S, Hamvas, Aaron

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