Search Results - "Hackam, D J"

Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor by Good, M, Sodhi, C P, Egan, C E, Afrazi, A, Jia, H, Yamaguchi, Y, Lu, P, Branca, M F, Ma, C, Prindle, T, Mielo, S, Pompa, A, Hodzic, Z, Ozolek, J A, Hackam, D J

“…Breast milk is the most effective strategy to protect infants against necrotizing enterocolitis (NEC), a devastating disease that is characterized by severe…”
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Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice by Lu, P, Sodhi, C P, Yamaguchi, Y, Jia, H, Prindle, T, Fulton, W B, Vikram, A, Bibby, K J, Morowitz, M J, Hackam, D J

“…Little is known about the pathogenesis of metabolic syndrome, although Toll-like receptor 4 (TLR4) has been implicated. We investigated whether TLR4 in the…”
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The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model by Sung, J., Sodhi, C. P., Voltaggio, L., Hou, X., Jia, H., Zhou, Q., Čiháková, D., Hackam, D. J.

“…Mucosal healing occurs through migration and proliferation of cells within injured epithelium, yet these processes may be inadequate for mucosal healing after…”
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Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide relevance to laparoscopic surgery by WEST, M. A, HACKAM, D. J, BAKER, J, RODRIGUEZ, J. L, BELLINGHAM, J, ROTSTEIN, O. D

“…The objective of this study was to determine the effect of carbon dioxide (CO2) on the function of peritoneal macrophages. Laparoscopic surgery is associated…”
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Diagnosis and outcome of Hirschsprung's disease: does age really matter? by Hackam, D J, Reblock, K K, Redlinger, R E, Barksdale, Jr, E M

“…Although Hirschsprung's disease (HD) typically presents in the newborn period, it is often diagnosed in older children, in whom the presentation and management…”
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Functional Expression of Nramp1 In Vitro in the Murine Macrophage Line RAW264.7 by GOVONI, G, CANONNE-HERGAUX, F, PFEIFER, C. G, MARCUS, S. L, MILLS, S. D, HACKAM, D. J, GRINSTEIN, S, MALO, D, FINLAY, B. B, GROS, P

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Enterocolitis after the surgical treatment of Hirschsprung's disease: Risk factors and financial impact by Hackam, David J, Filler, R.M, Pearl, Richard H

“…Background/Purpose: Enterocolitis (EC) represents a serious complication after the surgical correction of Hirschsprung's disease (HD). Although previous…”
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Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes by Hackam, DJ, Rotstein, OD, Bennett, MK, Klip, A, Grinstein, S, Manolson, MF

“…Phagosomes formed during ingestion of microorganisms by leukocytes undergo a rapid maturation, generating an acidic, microbicidal organelle. Maturation…”
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The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes by Gruenheid, S, Canonne-Hergaux, F, Gauthier, S, Hackam, D J, Grinstein, S, Gros, P

“…The natural resistance associated macrophage protein (Nramp) gene family is composed of two members in mammals, Nramp1 and Nramp2. Nramp1 is expressed…”
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Endotoxin Inhibits Intestinal Epithelial Restitution through Activation of Rho-GTPase and Increased Focal Adhesions by Cetin, Selma, Ford, Henri R, Sysko, Laura R, Agarwal, Charu, Wang, James, Neal, Matthew D, Baty, Catherine, Apodaca, Gerard, Hackam, David J

“…Diseases of gut inflammation such as neonatal necrotizing enterocolitis (NEC) result after an injury to the mucosal lining of the intestine, leading to…”
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Stoma closure and wound infection: an evaluation of risk factors by Hackam, D J, Rotstein, O D

“…To assess the infection rate in the nonstoma wound in patients who undergo stoma closure. Chart review. A tertiary-care hospital. Ninety-five patients who…”
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Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification by Hackam, D J, Rotstein, O D, Zhang, W, Gruenheid, S, Gros, P, Grinstein, S

“…The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the…”
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Single-stage repair of Hirschsprung's disease: A comparison of 109 patients over 5 years by Hackam, David J, Superina, Riccardo A, Pearl, Richard H

“…Current management of Hirschsprung's disease (HD) typically involves staged therapy, which necessitates multiple hospital admissions and associated costs. The…”
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Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages by Hackam, David J., Rotstein, Ori D., Schreiber, Alan, Zhang, Wei-jian, Grinstein, Sergio

“…Phagocytosis of bacteria by macrophages and neutrophils is an essential component of host defense against infection. The mechanism whereby the interaction of…”
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Regulation of phagosomal acidification. Differential targeting of Na+/H+ exchangers, Na+/K+-ATPases, and vacuolar-type H+-atpases by Hackam, D J, Rotstein, O D, Zhang, W J, Demaurex, N, Woodside, M, Tsai, O, Grinstein, S

“…Vacuolar-type (V) ATPases are thought to be the main determinant of phagosomal acidification. In phagosomes containing mycobacteria, which ostensibly impair…”
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v-SNARE-Dependent Secretion Is Required for Phagocytosis by Hackam, David J., Rotstein, Ori D., Sjolin, Carola, Schreiber, Alan D., Trimble, William S., Grinstein, Sergio

“…Phagosomes are generally believed to form by gradual apposition of the plasma membrane of leukocytes onto the surface of invading microorganisms. The…”
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Wound infection during stoma closure by Hackam, D J, Rotstein, O D

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Role of COPI in Phagosome Maturation by Botelho, Roberto J., Hackam, David J., Schreiber, Alan D., Grinstein, Sergio

“…Phagosomes mature by sequentially fusing with endosomes and lysosomes. Vesicle budding is presumed to occur concomitantly, mediating the retrieval of…”
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Snow-related recreational injuries in children: Assessment of morbidity and management strategies by Hackam, David J, Kreller, Margaret, Pearl, Richard H

“…Purpose: The aim of this study was to investigate the causes, clinical course, and financial impact of snow-related sport injuries in children. Methods:…”
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The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation by Gribar, Steven C., Anand, Rahul J., Sodhi, Chhinder P., Hackam, David J.

“…Emerging evidence suggests that the innate immune system, comprised of Toll‐like receptors (TLRs) and their associated molecules, plays a pivotal role in the…”
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