Search Results - "Hack, P"

Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities by Hack, Stephen P, Zhu, Andrew X, Wang, Yulei

“…Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the…”
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IMbrave 050: a Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation by Hack, Stephen P, Spahn, Jessica, Chen, Minshan, Cheng, Ann-Lii, Kaseb, Ahmed, Kudo, Masatoshi, Lee, Han Chu, Yopp, Adam, Chow, Pierce, Qin, Shukui

“…Hepatocellular carcinoma recurs in 70–80% of cases following potentially curative resection or ablation and the immune component of the liver microenvironment…”
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Thermodynamic fluctuation theorems govern human sensorimotor learning by Hack, P., Lindig-Leon, C., Gottwald, S., Braun, D. A.

“…The application of thermodynamic reasoning in the study of learning systems has a long tradition. Recently, new tools relating perfect thermodynamic adaptation…”
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Effects of Acute Guarana ( Paullinia cupana ) Ingestion on Mental Performance and Vagal Modulation Compared to a Low Dose of Caffeine by Talik, Tyler N, Penna, Eduardo Macedo, Hack, Brian P, Harp, Alec, Millard-Stafford, Mindy

“…Guarana (GUA), a Brazilian seed extract, contains caffeine and other bioactive compounds that may have psychoactive effects. To assess the acute effects of GUA…”
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HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development by Hack, Stephen P, Bruey, Jean-Marie, Koeppen, Hartmut

“…Aberrant activation of the HGF/MET signaling axis has been strongly implicated in the malignant transformation and progression of gastroesophageal cancer…”
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IMbrave 151: a randomized phase II trial of atezolizumab combined with bevacizumab and chemotherapy in patients with advanced biliary tract cancer by Hack, Stephen P., Verret, Wendy, Mulla, Sohail, Liu, Bo, Wang, Yulei, Macarulla, Teresa, Ren, Zhenggang, El-Khoueiry, Anthony B., Zhu, Andrew X.

“…Background: Biliary tract cancers (BTCs) are heterogenous, highly aggressive tumors that harbor a dismal prognosis for which more effective treatments are…”
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Towards implementation of reverse electrodialysis for power generation from salinity gradients by Post, J.W., Goeting, C.H., Valk, J., Goinga, S., Veerman, J., Hamelers, H.V.M., Hack, P.J.F.M.

“…Reverse electrodialysis is a conversion technique to obtain electricity from salinity gradients. Over the past few years, the performance of reverse…”
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Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis by Droppa, Michal, Rudolph, Tanja K., Baan, Jan, Nielsen, Niels-Erik, Baumgartner, Helmut, Vendrik, Jeroen, Froehlich, Maren, Borst, Oliver, Wöhrle, Jochen, Gawaz, Meinrad, Potratz, Paul, Hack, Luis P., Mauri, Victor, Baranowski, Jacek, Bramlage, Peter, Kurucova, Jana, Thoenes, Martin, Rottbauer, Wolfgang, Geisler, Tobias

“…Permanent pacemaker implantation (PPI) is a widely recognized complication associated with TAVI (incidence up to 20%). Smaller registries have identified…”
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A 233-MHz 80%-87% efficient four-phase DC-DC converter utilizing air-core inductors on package by Hazucha, P., Schrom, G., Jaehong Hahn, Bloechel, B.A., Hack, P., Dermer, G.E., Narendra, S., Gardner, D., Karnik, T., De, V., Borkar, S.

“…We demonstrate an integrated buck dc-dc converter for multi-V/sub CC/ microprocessors. At nominal conditions, the converter produces a 0.9-V output from a…”
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Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro by Hack, Stephen P, Vaughan, Christopher W, Christie, MacDonald J

“…Chronic treatment with opioids induces adaptations in neurons leading to tolerance and dependence. Studies have implicated the midbrain periaqueductal gray…”
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GABA Transporter Currents Activated by Protein Kinase A Excite Midbrain Neurons during Opioid Withdrawal by Bagley, Elena E., Gerke, Michelle B., Vaughan, Christopher W., Hack, Stephen P., Christie, MacDonald J.

“…Adaptations in neurons of the midbrain periaqueductal gray (PAG) induced by chronic morphine treatment mediate expression of many signs of opioid withdrawal…”
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Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment by Hack, Stephen P, Bagley, Elena E, Chieng, Billy C H, Christie, MacDonald J

“…Delta-opioid receptor (DOPr) activation fails to produce cellular physiological responses in many brain regions, including the periaqueductal gray (PAG),…”
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Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma by Larkin, James, Ascierto, Paolo A, Dréno, Brigitte, Atkinson, Victoria, Liszkay, Gabriella, Maio, Michele, Mandalà, Mario, Demidov, Lev, Stroyakovskiy, Daniil, Thomas, Luc, de la Cruz-Merino, Luis, Dutriaux, Caroline, Garbe, Claus, Sovak, Mika A, Chang, Ilsung, Choong, Nicholas, Hack, Stephen P, McArthur, Grant A, Ribas, Antoni

“…The combination of inhibitors to BRAF and MEK improved response rates and progression-free survival among patients with metastatic melanoma. Some toxicity was…”
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Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study by Lee, Michael S, Ryoo, Baek-Yeol, Hsu, Chih-Hung, Numata, Kazushi, Stein, Stacey, Verret, Wendy, Hack, Stephen P, Spahn, Jessica, Liu, Bo, Abdullah, Heba, Wang, Yulei, He, Aiwu Ruth, Lee, Kyung-Hun, Bang, Y-J, Bendell, J, Chao, Y, Chen, J-S, Chung, H C, Davis, S L, Dev, A, Gane, E, George, B, He, A R, Hochster, H, Hsu, C-H, Ikeda, M, Lee, J, Lee, M, Mahipal, A, Manji, G, Morimoto, M, Numata, K, Pishvaian, M, Qin, S, Ryan, D, Ryoo, B-Y, Sasahira, N, Stein, S, Strickler, J, Tebbutt, N

“…Dual blockade of PD-L1 and VEGF has enhanced anticancer immunity through multiple mechanisms and augmented antitumour activity in multiple malignancies. We…”
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Serotonergic and Nonserotonergic Dorsal Raphe Neurons Are Pharmacologically and Electrophysiologically Heterogeneous by Marinelli, Silvia, Schnell, Stephen A, Hack, Stephen P, Christie, MacDonald J, Wessendorf, Martin W, Vaughan, Christopher W

“…1 Pain Management Research Institute, Northern Clinical School, University of Sydney, Sydney, New South Wales, 2006 Australia; and 2 Department of…”
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Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal Adenocarcinoma: The METGastric Randomized Clinical Trial by Shah, Manish A, Bang, Yung-Jue, Lordick, Florian, Alsina, Maria, Chen, Meng, Hack, Stephen P, Bruey, Jean Marie, Smith, Dustin, McCaffery, Ian, Shames, David S, Phan, See, Cunningham, David

“…Dysregulation of the mesenchymal-epithelial transition (MET) signaling pathway is associated with poor prognosis in gastroesophageal adenocarcinoma (GEC). We…”
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Atezolizumab: an investigational agent for the treatment of biliary tract cancer by Hack, Stephen P, Zhu, Andrew X

“…Biliary tract cancers (BTCs) have a dismal prognosis and limited treatment options. The role of immunotherapy in BTC is unclear. BTCs respond poorly to PD-(L)1…”
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Early Decision Making in a Randomized Phase II Trial of Atezolizumab in Biliary Tract Cancer Using a Tumor Growth Inhibition‐Survival Modeling Framework by Shemesh, Colby S., Chan, Phyllis, Marchand, Mathilde, Gonçalves, Antonio, Vadhavkar, Shweta, Wu, Benjamin, Li, Chunze, Jin, Jin Y., Hack, Stephen P., Bruno, Rene

“…We assess the longitudinal tumor growth inhibition (TGI) metrics and overall survival (OS) predictions applied to patients with advanced biliary tract cancer…”
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On the Synchronizing Mechanisms of Tetanically Induced Hippocampal Oscillations by Bracci, Enrico, Vreugdenhil, Martin, Hack, Stephen P, Jefferys, John G. R

“…gamma (30-100 Hz) and beta (10-30 Hz) oscillations follow tetanic stimulation in the CA1 region of the rat hippocampal slice. Pyramidal neurons undergo a slow…”
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Atezolizumab Plus Chemotherapy With or Without Bevacizumab in Advanced Biliary Tract Cancer: Clinical and Biomarker Data From the Randomized Phase II IMbrave151 Trial by Macarulla, Teresa, Ren, Zhenggang, Chon, Hong Jae, Park, Joon Oh, Kim, Jin Won, Pressiani, Tiziana, Li, Daneng, Zhukova, Lyudmila, Zhu, Andrew X, Chen, Ming-Huang, Hack, Stephen P, Wu, Stephanie, Liu, Bo, Guan, Xiangnan, Lu, Shan, Wang, Yulei, El-Khoueiry, Anthony B

“…Biliary tract cancers (BTCs) harbor an immunosuppressed tumor microenvironment and respond poorly to PD-1/PD-L1 inhibitors. Bevacizumab (anti-vascular…”
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